PTH (1-34) Human

Parathyroid Hormone (1-34) Human

Synthetic human parathyroid hormone (C181H291N55O51S2) is a peptide composed of 34 amino acids with a molecular weight of 4117.72 Daltons.
The purification of PTH is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT18359
Appearance
White, sterile-filtered lyophilized powder.

PTH (1-84) Human

Parathyroid Hormone (1-84) Human Recombinant

Parathyroid Hormone 1-84 (full length) Human Recombinant, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 84 amino acids, with a molecular weight of approximately 9.4 kDa. The PTH is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19490
Source
Escherichia Coli.
Appearance
Sterile Filtered White Lyophilized (Freeze-Dried) Powder

PTH (1-84) N15 Human

Parathyroid Hormone (1-84) N15 Labeled Human Recombinant

Recombinant Human PTH (1-84) N15, produced in E. coli, is a single, non-glycosylated polypeptide chain composed of 84 amino acids. It has a molecular mass of 9550 Daltons and is labeled with the stable isotope N15. The purification process for PTH (1-84) N15 involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19582
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

PTH (7-34) Human

Parathyroid Hormone (7-34) Human Recombinant

Recombinant Human Parathyroid Hormone (PTH) is a single, non-glycosylated polypeptide chain comprising 28 amino acids with a molecular weight of 3380 Daltons. Produced in E. coli, it is purified using advanced chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19657
Source
Escherichia Coli.
Appearance
White, sterile, lyophilized powder.

PTH (7-84) Human

Parathyroid Hormone (7-84) Human Recombinant

Recombinant Human PTH (7-84) is produced in E. coli. It is a single, non-glycosylated polypeptide chain comprised of 76 amino acids with a molecular weight of 8.8 kDa. The purification of PTH (7-84) is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19731
Source
Escherichia Coli.
Appearance
White, sterile-filtered lyophilized (freeze-dried) powder.

PTH (7-84) N15 Human

Parathyroid Hormone (7-84) N15 Labeled Human Recombinant

Recombinant Human PTH (7-84) N15, produced in E. coli, is a single, non-glycosylated polypeptide chain composed of 78 amino acids. With a molecular mass of 8900 Daltons, it is labeled with the stable isotope N15. This product is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19882
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder supplied in sterile vials.

PTH Human

Parathyroid Hormone (1-34) Human Recombinant

Recombinant Human Parathyroid Hormone (C181H290N55O51S2), produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 84 amino acids with a molecular weight of 4117.8 Daltons. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19959
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

PTHrP Human

Parathyroid Hormone Related Protein Human Recombinant

Recombinant human PTHrP, produced in E. coli, is a single, non-glycosylated polypeptide chain composed of 86 amino acids, with a molecular weight of 9.9 kDa. PTHrP is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT20042
Source
Escherichia Coli.
Appearance
Sterile, filtered, white, lyophilized (freeze-dried) powder.

PTHrP N15 Human

Parathyroid Hormone Related Protein N15 Labeled Human Recombinant

Recombinant human PTHrP N15, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 86 amino acids. It has a molecular weight of 10033 Da and is labeled with the stable isotope N15. The purification of PTHrP is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20133
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.
Definition and Classification

Parathyroid hormone (PTH), also known as parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands. It plays a crucial role in regulating serum calcium concentration through its effects on bone, kidney, and intestine . PTH is classified as a polypeptide hormone and consists of 84 amino acids .

Biological Properties

Key Biological Properties: PTH is a key regulator of calcium and phosphate metabolism in the body. It is secreted in response to low blood serum calcium levels and acts to increase serum calcium .

Expression Patterns: PTH is primarily expressed in the chief cells of the parathyroid glands .

Tissue Distribution: PTH receptors are found in various tissues, including bone, kidney, central nervous system, pancreas, testes, and placenta .

Biological Functions

Primary Biological Functions: The primary function of PTH is to maintain calcium homeostasis. It stimulates the release of calcium from bones, reduces calcium excretion in the urine, and increases calcium absorption in the intestines .

Role in Immune Responses and Pathogen Recognition: While PTH is not directly involved in immune responses or pathogen recognition, its role in maintaining calcium homeostasis indirectly supports various physiological processes, including immune function .

Modes of Action

Mechanisms with Other Molecules and Cells: PTH exerts its effects by binding to specific receptors on target cells. There are two main types of PTH receptors: PTH1 receptors, which are present in high levels on bone and kidney cells, and PTH2 receptors, which are found in the central nervous system, pancreas, testes, and placenta .

Binding Partners and Downstream Signaling Cascades: Upon binding to its receptors, PTH activates several downstream signaling pathways, including the cyclic AMP (cAMP) pathway, which leads to the activation of protein kinase A (PKA) and subsequent cellular responses .

Regulatory Mechanisms

Regulatory Mechanisms: The expression and activity of PTH are tightly regulated by serum calcium levels. Low calcium levels stimulate PTH secretion, while high calcium levels inhibit it . Additionally, PTH gene expression is regulated by vitamin D, phosphate, and fibroblast growth factor 23 (FGF23) .

Transcriptional Regulation and Post-Translational Modifications: PTH gene transcription is influenced by various factors, including vitamin D response elements (VDREs) in the gene promoter . Post-translational modifications, such as phosphorylation, also play a role in regulating PTH activity .

Applications

Biomedical Research: PTH is extensively studied in the context of bone metabolism and calcium homeostasis. It serves as a model for understanding hormone-receptor interactions and signaling pathways .

Diagnostic Tools: PTH assays are used to diagnose and monitor conditions such as hyperparathyroidism, hypoparathyroidism, and chronic kidney disease .

Therapeutic Strategies: PTH analogs, such as teriparatide, are used in the treatment of osteoporosis to stimulate bone formation .

Role in the Life Cycle

Development to Aging and Disease: PTH plays a critical role throughout the life cycle. During development, it ensures proper bone formation and mineralization. In adulthood, it maintains calcium homeostasis and bone health. Dysregulation of PTH can lead to conditions such as osteoporosis, hyperparathyroidism, and hypoparathyroidism .

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