MIG Bovine

MIG (CXCL9) Bovine Recombinant

Recombinant Bovine MIG (CXCL9), produced in E. coli, is a non-glycosylated polypeptide chain composed of 104 amino acids. With a molecular weight of approximately 18.0 kDa, MIG undergoes purification using proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT19487
Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

MIG Human

MIG Human Recombinant (CXCL9)

Recombinant Human MIG, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 103 amino acids, resulting in a molecular weight of 11.7 kDa. The purification process involves proprietary chromatographic techniques to ensure high purity.

Shipped with Ice Packs
Cat. No.
BT19564
Source
Escherichia Coli.
Appearance
The product appears as a sterile, white powder that has been lyophilized (freeze-dried).

MIG Human, His

MIG Human Recombinant (CXCL9), His Tag

Recombinant Human MIG, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 126 amino acids (specifically, residues 23-125). It has a molecular weight of 14 kDa. The MIG protein is fused to a 23 amino acid His-tag at its N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19643
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

MIG Mouse

MIG Mouse Recombinant (CXCL9)

Recombinant Mouse MIG (CXCK9) is produced in E. coli. It is a single, non-glycosylated polypeptide chain consisting of 105 amino acids with a molecular weight of 12.2 kDa. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19714
Source
Escherichia Coli.
Appearance
White, sterile, lyophilized powder.
Definition and Classification

Chemokine (C-X-C motif) ligand 9 (CXCL9), also known as monokine induced by gamma interferon (MIG), is a small cytokine belonging to the CXC chemokine family . CXCL9 is primarily involved in immune responses and plays a crucial role in the chemotaxis of immune cells .

Biological Properties

Key Biological Properties: CXCL9 is known for its cytokine activity, chemokine receptor binding, and protein binding capabilities . It is involved in various biological processes, including chemotaxis, immune response, and inflammatory response .

Expression Patterns: CXCL9 is expressed in various tissues, including the appendix, lymph nodes, nasal mucosa, and testicles . It is also found in subcutaneous adipose tissue, mesenteric lymph nodes, and the spleen .

Tissue Distribution: The expression of CXCL9 is widespread, with significant levels in the lymphoid tissues and other organs involved in immune responses .

Biological Functions

Primary Biological Functions: CXCL9 plays a pivotal role in inducing chemotaxis, promoting the differentiation and multiplication of leukocytes, and causing tissue extravasation . It is essential for the recruitment of immune cells such as cytotoxic lymphocytes, natural killer cells, and macrophages .

Role in Immune Responses: CXCL9 is involved in the recruitment and activation of immune cells, contributing to the body’s defense against pathogens . It also plays a role in Th1 polarization, which activates immune cells in response to interferon-gamma (IFN-γ) .

Pathogen Recognition: CXCL9 is involved in the immune response to various pathogens, including bacteria and viruses .

Modes of Action

Mechanisms with Other Molecules and Cells: CXCL9 interacts with its receptor CXCR3 to regulate immune cell migration, differentiation, and activation . This interaction is crucial for the recruitment of immune cells to sites of inflammation or infection .

Binding Partners: CXCL9 primarily binds to the CXCR3 receptor, which is expressed on various immune cells .

Downstream Signaling Cascades: The binding of CXCL9 to CXCR3 activates downstream signaling pathways, including the G protein-coupled receptor signaling pathway and the chemokine-mediated signaling pathway .

Regulatory Mechanisms

Transcriptional Regulation: The expression of CXCL9 is regulated by various transcription factors, including those activated by IFN-γ .

Post-Translational Modifications: CXCL9 undergoes post-translational modifications that can affect its activity and stability .

Applications

Biomedical Research: CXCL9 is extensively studied in the context of immune responses and inflammatory diseases . It is also investigated for its role in cancer and other pathological conditions .

Diagnostic Tools: CXCL9 can serve as a biomarker for various diseases, including cancers and inflammatory conditions .

Therapeutic Strategies: Targeting the CXCL9/CXCR3 axis is being explored as a potential therapeutic strategy for enhancing immune responses and treating cancers .

Role in the Life Cycle

Development: CXCL9 plays a role in the development of the immune system by regulating the migration and differentiation of immune cells .

Aging: The expression and activity of CXCL9 can change with age, potentially affecting immune responses in older individuals .

Disease: CXCL9 is involved in various diseases, including cancers, inflammatory conditions, and infectious diseases . Its role in these diseases makes it a potential target for therapeutic interventions .

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