Product List

TECK Human

Thymus Expressed Chemokine Human Recombinant (CCL25)

TECK Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 127 amino acids and having a molecular mass of 14.2kDa.
The TECK is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24972
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

TECK Human, His

Thymus Expressed Chemokine (CCL25) Human Recombinant, His Tag

TECK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids (24-150 a.a.) and having a molecular mass of 16.8kDa.
TECK is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25039
Source
Escherichia Coli.
Appearance
Filtered colorless solution.

TECK Mouse

Thymus Expressed Chemokine Mouse Recombinant (CCL25)

TECK Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 121 amino acids and having a molecular mass of 14.1kDa. The TECK is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25127
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

Introduction

Definition and Classification

Thymus Expressed Chemokine (CCL25), also known as TECK (Thymus-Expressed Chemokine), is a small cytokine belonging to the CC chemokine family . It is chemotactic for thymocytes, macrophages, and dendritic cells . CCL25 is encoded by the CCL25 gene located on human chromosome 19 .

Biological Properties

Key Biological Properties: CCL25 is a small cytokine with a molecular mass of approximately 16.6 kDa. It is produced as a protein precursor containing 151 amino acids .

Expression Patterns and Tissue Distribution: CCL25 is primarily expressed in the thymus and small intestine . It is produced by medullary dendritic cells and cortical epithelial cells in the thymus .

Biological Functions

Primary Biological Functions: CCL25 plays a crucial role in the development of T-cells . It is involved in the chemotaxis of thymocytes, macrophages, and dendritic cells .

Role in Immune Responses and Pathogen Recognition: CCL25 is essential for the development, homeostasis, and function of mucosal T lymphocytes . It promotes the migration of immune cells to sites of inflammation and infection .

Modes of Action

Mechanisms with Other Molecules and Cells: CCL25 exerts its effects by binding to the chemokine receptor CCR9 . This binding induces chemotactic responses in thymocytes, macrophages, and dendritic cells.

Binding Partners and Downstream Signaling Cascades: The primary binding partner of CCL25 is CCR9. Upon binding, CCL25 activates downstream signaling pathways that promote cell migration and immune responses.

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: The expression of CCL25 is regulated at the transcriptional level by various cytokines and transcription factors . Post-translational modifications, such as glycosylation, also play a role in regulating the activity of CCL25 .

Applications

Biomedical Research: CCL25 is used in research to study T-cell development and immune responses .

Diagnostic Tools: Elevated levels of CCL25 have been associated with various inflammatory diseases, making it a potential biomarker for diagnosis .

Therapeutic Strategies: Targeting the CCR9-CCL25 axis has shown promise in treating inflammatory diseases and certain cancers .

Role in the Life Cycle

Development to Aging and Disease: CCL25 plays a vital role in the development and trafficking of T-cells throughout life . Its expression and activity are crucial for maintaining immune homeostasis and responding to infections and inflammation . Dysregulation of CCL25 has been linked to various diseases, including inflammatory bowel disease and cancer .

© Copyright 2024 Thebiotek. All Rights Reserved.