Product List

NAP 2 95 a.a. Human

Neutrophil Activating Protein-2 (CXCL7) Human Recombinant, 95 a.a.

NAP 2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 95 amino acids (35-128) and having a molecular mass of 10.3 kDa.
The NAP 2 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21980
Source
Escherichia Coli.
Appearance
NAP 2 is supplied as a sterile filtered clear solution.

NAP 2 Human

Neutrophil Activating Protein-2 Human Recombinant (CXCL7)

Neutrophil Activating Protein-2 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7609 Dalton.
The NAP-2 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22041
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

NAP 2 Rat

Neutrophil Activating Protein-2 Rat Recombinant (CXCL7)

NAP-2 Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 62 amino acids and having a molecular mass of 6.8kDa.
The NAP 2 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22140
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

Introduction

Definition and Classification

NAP-2 (Neutrophil Activating Protein-2), also known as CXCL7, is a member of the CXC chemokine family. It is derived from the platelet basic protein (PBP) and is a potent chemoattractant and activator of neutrophils .

Biological Properties

Key Biological Properties: NAP-2 is a small cytokine that plays a crucial role in immune responses. It is produced in leukocytes by enzymatic processing of PBP .

Expression Patterns: NAP-2 is primarily expressed in platelets and is released upon their activation .

Tissue Distribution: It is found in high concentrations in the blood and is also present in various tissues, including the bone marrow and spleen .

Biological Functions

Primary Biological Functions: NAP-2 is involved in the chemotaxis and activation of neutrophils. It stimulates various cellular processes, including mitosis, extracellular matrix production, and angiogenesis .

Role in Immune Responses: NAP-2 plays a significant role in orchestrating neutrophil recruitment in response to vascular injury and inflammation .

Pathogen Recognition: It aids in the immune response by attracting neutrophils to sites of infection or injury, thereby facilitating pathogen recognition and clearance .

Modes of Action

Mechanisms with Other Molecules and Cells: NAP-2 exerts its function by activating the CXC chemokine receptor 2 (CXCR2) receptor and binding sulfated glycosaminoglycans (GAGs) that regulate receptor activity .

Binding Partners: It interacts with CXCR2 and GAGs to mediate its effects .

Downstream Signaling Cascades: Upon binding to CXCR2, NAP-2 triggers downstream signaling pathways that lead to neutrophil activation and migration .

Regulatory Mechanisms

Regulatory Mechanisms: The expression and activity of NAP-2 are regulated at multiple levels, including transcriptional regulation and post-translational modifications .

Transcriptional Regulation: The production of NAP-2 is controlled by various transcription factors that respond to inflammatory signals .

Post-Translational Modifications: NAP-2 undergoes proteolytic processing to generate its active form .

Applications

Biomedical Research: NAP-2 is used in research to study its role in inflammation, immune responses, and cancer .

Diagnostic Tools: It serves as a biomarker for various inflammatory and immune-related conditions .

Therapeutic Strategies: NAP-2 is being explored as a target for therapeutic interventions in diseases characterized by excessive inflammation and neutrophil activation .

Role in the Life Cycle

Development: NAP-2 is involved in the development of the immune system by regulating neutrophil function .

Aging: Its role in inflammation makes it relevant in age-related inflammatory conditions .

Disease: NAP-2 is implicated in various diseases, including cancer, where it promotes tumor growth and metastasis through its angiogenic and mitotic roles .

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