Chemokines
Product List
TARC Human
Thymus & Activation Regulated Chemokine Human Recombinant (CCL17)
TARC Human, His
Thymus and Activation Regulated Chemokine Human Recombinant (CCL17), His Tag
TARC Macaque
Thymus and Activation Regulated Chemokine (CCL17) Rhesus Macaque Recombinant
Recombinant Thymus and Activation Regulated Chemokine (CCL17) from Rhesus Macaque, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 71 amino acids. It has a molecular weight of approximately 8.1 kDa. The purification of TRAC is achieved using proprietary chromatographic methods.
Escherichia Coli.
Sterile Filtered White lyophilized (freeze-dried) powder.
TARC Mouse
Thymus and Activation Regulated Chemokine (CCL17) Mouse Recombinant
TARC Rat
Thymus and Activation Regulated Chemokine (CCL17) Rat Recombinant
Introduction
Thymus and activation-regulated chemokine (TARC), also known as CCL17, is a member of the CC chemokine family. It was initially identified in 1996 and is classified under the C-C motif chemokine ligand 17 . Chemokines are small cytokines that play crucial roles in immune cell trafficking and activation.
Key Biological Properties: CCL17 is a potent chemokine produced primarily in the thymus and by antigen-presenting cells such as dendritic cells, macrophages, and monocytes . It is involved in the recruitment of T cells to sites of inflammation.
Expression Patterns: CCL17 is constitutively expressed in the thymus and can be induced in other tissues under inflammatory conditions .
Tissue Distribution: It is found in various tissues, including the thymus, lymph nodes, and inflamed tissues .
Primary Biological Functions: CCL17 plays a significant role in the immune system by recruiting T-helper cells to sites of inflammation . It is involved in the development and trafficking of T cells in the thymus and peripheral tissues .
Role in Immune Responses: CCL17 is crucial in type 2 immune responses, particularly in conditions like allergic asthma and atopic dermatitis . It helps in the recruitment of T-helper cells to inflamed tissues, facilitating an immune response.
Pathogen Recognition: While CCL17 itself is not directly involved in pathogen recognition, it recruits immune cells that are essential for recognizing and responding to pathogens .
Mechanisms with Other Molecules and Cells: CCL17 exerts its effects by binding to chemokine receptors CCR4 and CCR8 on target cells . This binding induces chemotaxis, guiding the migration of T-helper cells to sites of inflammation .
Binding Partners: The primary binding partners of CCL17 are the chemokine receptors CCR4 and CCR8 .
Downstream Signaling Cascades: Upon binding to its receptors, CCL17 activates downstream signaling pathways that lead to the migration and activation of T-helper cells .
Regulatory Mechanisms: The expression of CCL17 is regulated by various cytokines, including GM-CSF and IL-4 . GM-CSF induces CCL17 expression via Jmjd3-regulated IRF4, which mediates inflammation .
Transcriptional Regulation: Transcription factors such as IRF4 play a crucial role in the regulation of CCL17 expression .
Post-Translational Modifications: Specific post-translational modifications that regulate CCL17 activity are not well-documented, but its expression and function are tightly controlled by cytokine signaling .
Biomedical Research: CCL17 is widely studied in the context of immune responses and inflammatory diseases. It serves as a biomarker for various conditions, including allergic asthma and atopic dermatitis .
Diagnostic Tools: Elevated levels of CCL17 can be used as a diagnostic marker for certain eosinophilic disorders and inflammatory conditions .
Therapeutic Strategies: Targeting the CCL17-CCR4 axis holds potential for therapeutic interventions in diseases characterized by excessive T-helper cell recruitment and inflammation .
Development: CCL17 is involved in the development of T cells in the thymus .
Aging: The role of CCL17 in aging is not well-documented, but its involvement in chronic inflammatory conditions suggests it may play a role in age-related immune dysregulation .
Disease: CCL17 is implicated in various diseases, including allergic asthma, atopic dermatitis, and certain cancers . Its role in recruiting T-helper cells makes it a critical player in the pathogenesis of these conditions.
