Product List

TARC Human

Thymus & Activation Regulated Chemokine Human Recombinant (CCL17)

CCL17 Human Recombinant produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 71 amino acids and having a molecular mass of 8 kDa.
The TARC is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24577
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

TARC Human, His

Thymus and Activation Regulated Chemokine Human Recombinant (CCL17), His Tag

TARC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 92 amino acids (24-94 a.a.) and having a molecular mass of 10.3 kDa.
The TARC is fused to 21 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT24655
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

TARC Macaque

Thymus and Activation Regulated Chemokine (CCL17) Rhesus Macaque Recombinant

Thymus and Activation Regulated Chemokine (CCL17) Rhesus Macaque Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 71 amino acid and having a molecular mass of approximately 8.1kDa.
TRAC is purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT24736
Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

TARC Mouse

Thymus and Activation Regulated Chemokine (CCL17) Mouse Recombinant

TARC Mouse Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7.9kDa.
The TARC Mouse is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24822
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

TARC Rat

Thymus and Activation Regulated Chemokine (CCL17) Rat Recombinant

TARC Rat Recombinant produced in E.Coli is a non-glycosylated, polypeptide chain containing 70 amino acids and having a molecular mass of 8.1kDa.
The TARC Rat is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24905
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

Introduction

Definition and Classification

Thymus and activation-regulated chemokine (TARC), also known as CCL17, is a member of the CC chemokine family. It was initially identified in 1996 and is classified under the C-C motif chemokine ligand 17 . Chemokines are small cytokines that play crucial roles in immune cell trafficking and activation.

Biological Properties

Key Biological Properties: CCL17 is a potent chemokine produced primarily in the thymus and by antigen-presenting cells such as dendritic cells, macrophages, and monocytes . It is involved in the recruitment of T cells to sites of inflammation.

Expression Patterns: CCL17 is constitutively expressed in the thymus and can be induced in other tissues under inflammatory conditions .

Tissue Distribution: It is found in various tissues, including the thymus, lymph nodes, and inflamed tissues .

Biological Functions

Primary Biological Functions: CCL17 plays a significant role in the immune system by recruiting T-helper cells to sites of inflammation . It is involved in the development and trafficking of T cells in the thymus and peripheral tissues .

Role in Immune Responses: CCL17 is crucial in type 2 immune responses, particularly in conditions like allergic asthma and atopic dermatitis . It helps in the recruitment of T-helper cells to inflamed tissues, facilitating an immune response.

Pathogen Recognition: While CCL17 itself is not directly involved in pathogen recognition, it recruits immune cells that are essential for recognizing and responding to pathogens .

Modes of Action

Mechanisms with Other Molecules and Cells: CCL17 exerts its effects by binding to chemokine receptors CCR4 and CCR8 on target cells . This binding induces chemotaxis, guiding the migration of T-helper cells to sites of inflammation .

Binding Partners: The primary binding partners of CCL17 are the chemokine receptors CCR4 and CCR8 .

Downstream Signaling Cascades: Upon binding to its receptors, CCL17 activates downstream signaling pathways that lead to the migration and activation of T-helper cells .

Regulatory Mechanisms

Regulatory Mechanisms: The expression of CCL17 is regulated by various cytokines, including GM-CSF and IL-4 . GM-CSF induces CCL17 expression via Jmjd3-regulated IRF4, which mediates inflammation .

Transcriptional Regulation: Transcription factors such as IRF4 play a crucial role in the regulation of CCL17 expression .

Post-Translational Modifications: Specific post-translational modifications that regulate CCL17 activity are not well-documented, but its expression and function are tightly controlled by cytokine signaling .

Applications

Biomedical Research: CCL17 is widely studied in the context of immune responses and inflammatory diseases. It serves as a biomarker for various conditions, including allergic asthma and atopic dermatitis .

Diagnostic Tools: Elevated levels of CCL17 can be used as a diagnostic marker for certain eosinophilic disorders and inflammatory conditions .

Therapeutic Strategies: Targeting the CCL17-CCR4 axis holds potential for therapeutic interventions in diseases characterized by excessive T-helper cell recruitment and inflammation .

Role in the Life Cycle

Development: CCL17 is involved in the development of T cells in the thymus .

Aging: The role of CCL17 in aging is not well-documented, but its involvement in chronic inflammatory conditions suggests it may play a role in age-related immune dysregulation .

Disease: CCL17 is implicated in various diseases, including allergic asthma, atopic dermatitis, and certain cancers . Its role in recruiting T-helper cells makes it a critical player in the pathogenesis of these conditions.

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