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CD Antigens

CD79

Fc Fragment of IgG Receptor

CD164

sCD40L

Other CD Antigens

CD36

CD14

CD2

CD200

CD204

CD207

CD226

CD244

CD27

CD23

CD274

CD247

CD3

CD33

CD300

CD34

CD4

CD40

CD46

CD47

CD5

CD8B

CD5L

CD68

CD55

CD7

CD73

CD58

CD74

CD80

CD84

CD93

CD99

Product List

CD79A Human

CD79A Human Recombinant

Recombinant human CD79A, produced in Sf9 insect cells, is a single glycosylated polypeptide chain consisting of 119 amino acids (33-143a.a.) with a molecular mass of 13.6 kDa. Note that its size on SDS-PAGE may appear between 18-28 kDa. This protein is expressed with an 8 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT30782

Source

Sf9, Insect cells.

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CD79B Human

CD79B Human Recombinant

Recombinant human CD79B, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 155 amino acids (29-159a.a), resulting in a molecular weight of 17.7 kDa. The protein includes a 24 amino acid His-tag at the N-terminus and undergoes purification using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT30804

Source

E.coli.

Appearance

Clear, colorless solution, sterilized by filtration.

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CD79B Human, Sf9

CD79B Human Recombinant, Sf9

Recombinant human CD79B, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain. It encompasses amino acids 29-159a.a. (140 amino acids total) and has a molecular mass of 16.3 kDa. Note: On SDS-PAGE, the apparent molecular size will be approximately 18-28 kDa. This CD79B protein is expressed with a C-terminal 9-amino acid His tag and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT30832

Source

Sf9, Baculovirus cells.

Appearance

Clear, colorless solution, sterile-filtered.

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Introduction

Definition and Classification

CD79, also known as Cluster of Differentiation 79, is a transmembrane protein that forms a complex with the B-cell receptor (BCR) and generates a signal following the recognition of an antigen by the BCR. CD79 is composed of two distinct chains called CD79A and CD79B (also known as Igα and Igβ), which form a heterodimer on the surface of a B cell stabilized by disulfide bonding. Both CD79A and CD79B are members of the immunoglobulin superfamily.

Biological Properties

Key Biological Properties: CD79A and CD79B contain an immunoreceptor tyrosine-based activation motif (ITAM) in their intracellular tails, which they use to propagate a signal in a B cell.

Expression Patterns and Tissue Distribution: CD79 is expressed by B-cell and plasma cell precursors. It is highly expressed in immune tissues such as the spleen, head kidney, and kidney, with relatively low levels detected in the heart, gill, and liver.

Biological Functions

Primary Biological Functions: CD79 serves as a pan-B cell marker for the detection of B-cell neoplasms. It plays a crucial role in B cell development and antibody production.

Role in Immune Responses and Pathogen Recognition: CD79 is involved in the activation of B cells upon antigen recognition, leading to the initiation of immune responses.

Modes of Action

Mechanisms with Other Molecules and Cells: CD79 forms a complex with the BCR and generates a signal following antigen recognition. Upon antigen-induced BCR aggregation, CD79 is phosphorylated and initiates a cascade of downstream signaling events.

Binding Partners and Downstream Signaling Cascades: CD79 interacts with various signaling molecules, including SRC-family kinase LYN, SYK, phospholipase C (PLC)-γ, BLNK, and BTK, to propagate BCR signaling.

Regulatory Mechanisms

Transcriptional Regulation: The expression of CD79 is regulated at the transcriptional level by various transcription factors.

Post-Translational Modifications: CD79 undergoes post-translational modifications, including phosphorylation, which is crucial for its signaling function.

Applications

Biomedical Research: CD79 is used as a marker for B-cell neoplasms and is a target for therapeutic strategies in autoimmune diseases and B-cell malignancies.

Diagnostic Tools: CD79 monoclonal antibodies are used in diagnostic tools to detect B-cell neoplasms.

Therapeutic Strategies: CD79 is a target for antibody-drug conjugates and chimeric antigen receptor T cell therapies for autoimmunity and B cell neoplasia.

Role in the Life Cycle

Development: CD79 is essential for B cell development and maturation in the bone marrow.

Aging and Disease: CD79 expression and function are crucial throughout the life cycle of B cells, from development to aging and disease. It plays a role in maintaining B cell fitness and function.