CD Antigens
Product List
sCD40L Human, His Active
soluble CD40 Ligand/TRAP His Tag Active Human Recombinant
Escherichia Coli.
sCD40L Mouse
Soluble CD-40 Ligand/TRAP Mouse Recombinant
sCD40L Mouse, sf9
soluble CD40 Ligand/TRAPMouse Recombinant, sf9
sCD40L Human
Soluble CD-40 Ligand/TRAP Human Recombinant
sCD40L Human, His
soluble CD40 Ligand/TRAP Human Recombinant, His Tag
Introduction
Soluble CD40 Ligand (sCD40L) is a cleaved form of the membrane-bound CD40 Ligand (CD40L), also known as CD154. CD40L is a member of the tumor necrosis factor (TNF) superfamily and is primarily expressed on activated T cells and platelets . sCD40L is released into the circulation upon cleavage from the cell surface and retains its biological activity .
Key Biological Properties: sCD40L exhibits cytokine-like activity and plays a crucial role in immune responses and inflammation . It is involved in the activation of antigen-presenting cells (APCs), including dendritic cells, which are essential for initiating adaptive immune responses .
Expression Patterns and Tissue Distribution: sCD40L is primarily produced by activated T cells and platelets . It is found in the plasma and other body fluids, reflecting its systemic role in immune regulation .
Primary Biological Functions: sCD40L is involved in various immune processes, including the activation of B cells, macrophages, and dendritic cells . It plays a significant role in the formation of germinal centers, which are crucial for the generation of memory B cells and long-lived plasma cells .
Role in Immune Responses and Pathogen Recognition: sCD40L enhances the immune system’s ability to recognize and eliminate pathogens by promoting the activation and maturation of APCs . It also contributes to the production of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF-α .
Mechanisms with Other Molecules and Cells: sCD40L interacts with its receptor, CD40, which is expressed on various immune cells, including B cells, macrophages, and dendritic cells . This interaction triggers downstream signaling cascades that lead to the activation and differentiation of these cells .
Binding Partners and Downstream Signaling Cascades: Upon binding to CD40, sCD40L activates several signaling pathways, including the NF-κB and MAPK pathways . These pathways are involved in the regulation of immune responses, inflammation, and cell survival .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of sCD40L are tightly regulated at both the transcriptional and post-translational levels . Transcriptional regulation involves various transcription factors that bind to the promoter region of the CD40L gene . Post-translational modifications, such as cleavage by proteases, control the release of sCD40L from the cell surface .
Biomedical Research: sCD40L is widely used as a biomarker in various diseases, including cardiovascular diseases, autoimmune disorders, and cancers . Its role in immune regulation makes it a valuable target for studying immune responses and developing new therapeutic strategies .
Diagnostic Tools: Elevated levels of sCD40L in the blood are associated with several pathological conditions, making it a potential diagnostic marker for diseases such as sepsis, atherosclerosis, and cancer .
Therapeutic Strategies: sCD40L-based therapies are being explored for their potential to modulate immune responses in various diseases . For example, sCD40L chimeric proteins have been developed for targeted treatment of B-cell malignancies .
Role Throughout the Life Cycle: sCD40L plays a critical role in immune system development and function throughout life . During development, it is involved in the formation of germinal centers and the generation of memory B cells . In aging and disease, sCD40L levels can be altered, contributing to the pathogenesis of various conditions, including cardiovascular diseases and cancers .
