BTC Bovine

Betacellulin Bovine Recombinant

Recombinant Bovine Betacellulin, produced in E. coli, is a single-chain polypeptide with 80 amino acids. It is non-glycosylated and has a molecular weight of 9003 Daltons. Purification is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15700
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile filtered.

BTC His Human

Betacellulin Human Recombinant, His Tag

This recombinant human BTC protein is produced in E. coli bacteria. It is a single chain polypeptide with 101 amino acids (positions 32-111 of the full protein sequence), lacking any glycosylation modifications, and has a molecular weight of 11.3 kDa. For purification and detection purposes, a 21 amino acid His-tag is attached to the protein's N-terminus. The protein is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT15800
Source
E.coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

BTC Human

Betacellulin Human Recombinant

Recombinant Human Betacellulin, produced in E. coli, is a single-chain polypeptide with 80 amino acids. It is non-glycosylated and has a molecular weight of 9 kDa. The purification process involves specialized chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15893
Source
Escherichia Coli.
Appearance
White, sterile powder obtained by freeze-drying.

BTC Human, HEK

Betacellulin Human Recombinant, HEK

Recombinant Human BTC, expressed in HEK293 cells, is a single, glycosylated polypeptide chain encompassing amino acids 32-111. It consists of 86 amino acids, has a molecular weight of 9.8 kDa, and includes a 6-amino acid His-tag fused at the C-terminus. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT15991
Source

HEK293 cells.

Appearance
Sterile filtered colorless solution.

BTC Mouse

Betacellulin Mouse Recombinant

Recombinant Mouse BTC, produced in E. coli, is a single-chain polypeptide. It lacks glycosylation, consists of 80 amino acids, and has a molecular weight of 9.0 kDa. The purification of BTC is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16071
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.
Definition and Classification

Betacellulin (BTC) is a protein that belongs to the Epidermal Growth Factor (EGF) family. It is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21 in humans . Initially identified as a mitogen, betacellulin functions as a ligand for the epidermal growth factor receptor (EGFR) .

Biological Properties

Key Biological Properties: Betacellulin is known for its role in regulating growth and differentiation of various cell types, particularly pancreatic beta cells . It is a potent mitogen that promotes cell proliferation and differentiation .

Expression Patterns and Tissue Distribution: Betacellulin is expressed in a variety of tissues, including the pancreas, muscle layer of the sigmoid colon, skin, gastric mucosa, and retinal pigment epithelium . It is also found in Schwann cells, where it plays a role in nerve regeneration .

Biological Functions

Primary Biological Functions: Betacellulin’s primary function is to act as a ligand for EGFR, promoting cell proliferation and differentiation . It is involved in the regulation of pancreatic beta cell growth and insulin secretion .

Role in Immune Responses and Pathogen Recognition: While betacellulin’s primary functions are related to cell growth and differentiation, it also plays a role in immune responses by influencing the behavior of Schwann cells and neurons during nerve regeneration .

Modes of Action

Mechanisms with Other Molecules and Cells: Betacellulin binds to and activates EGFR and ErbB4 receptors . This binding initiates downstream signaling cascades, including the MAPK and PI3K/Akt pathways .

Binding Partners and Downstream Signaling Cascades: Betacellulin interacts with EGFR and ErbB4, leading to the activation of signaling pathways that promote cell proliferation, differentiation, and survival .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: Betacellulin expression is regulated at both the transcriptional and post-translational levels. Transcriptional regulation involves various signaling pathways, while post-translational modifications include proteolytic cleavage to release the active form of the protein .

Transcriptional Regulation and Post-Translational Modifications: The expression of betacellulin is controlled by transcription factors and signaling molecules that respond to cellular and environmental cues . Post-translational modifications, such as phosphorylation, further regulate its activity .

Applications

Biomedical Research: Betacellulin is used in research to study cell proliferation, differentiation, and regeneration, particularly in pancreatic beta cells .

Diagnostic Tools and Therapeutic Strategies: Betacellulin has potential applications in the development of diagnostic tools and therapeutic strategies for diseases such as diabetes and nerve injuries .

Role in the Life Cycle

Role Throughout the Life Cycle: Betacellulin plays a crucial role in various stages of life, from development to aging. It is involved in the differentiation of pancreatic beta cells during development and the regeneration of these cells in adults . Additionally, it promotes nerve regeneration following injury .

From Development to Aging and Disease: Betacellulin’s role in cell proliferation and differentiation makes it essential for normal development and tissue repair. Its involvement in diseases such as diabetes and nerve injuries highlights its therapeutic potential .

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