CTF1 Human

Cardiotrophin-1 Human Recombinant

Recombinant human Cardiotrophin-1, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 201 amino acids, resulting in a molecular weight of 21.2 kDa. The purification of CTF1 is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19793
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

CTF1 Human, His

Cardiotrophin-1 Human Recombinant, His Tag

Produced in E. coli, the Cardiotrophin His-Tagged Fusion Protein Human is a 22.5 kDa protein. It consists of 200 amino acid residues from human Cardiotrophin and a 12 amino acid residue His Tag (HHHHHH).
Shipped with Ice Packs
Cat. No.
BT19889
Source
Escherichia Coli.

CTF1 Mouse

Cardiotrophin-1 Mouse Recombinant

Recombinant CTF1 Mouse, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 202 amino acids. It has a molecular weight of 21.3 kDa. The purification of CTF1 Mouse is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT19967
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

CTF1 Rat

Cardiotrophin-1 Rat Recombinant

Recombinant Rat Cardiotrophin-1, produced in E. coli, is a single, non-glycosylated polypeptide chain composed of 203 amino acids, resulting in a molecular weight of 21.4 kDa. The purification of Rat CTF1 is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT20040
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

CTF2P Mouse

Neuropoietin Mouse Recombinant

Recombinant Mouse Neuropoietin, produced in E. coli, is a polypeptide chain that is not glycosylated. It consists of 182 amino acids, resulting in a molecular weight of approximately 19.7 kDa. The purification of CTF2P is achieved through specialized chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT20120
Source

Escherichia Coli.

Appearance

Sterile, white powder that has been lyophilized (freeze-dried) and filtered.

Definition and Classification

Cardiotrophin-1 (CT-1) is a cytokine belonging to the interleukin-6 (IL-6) superfamily of proinflammatory cytokines . It is a cardiac hypertrophic factor with a molecular weight of approximately 21.5 kDa . CT-1 is known for its role in inducing hypertrophy in cardiomyocytes and is associated with various cardiovascular diseases .

Biological Properties

Key Biological Properties: CT-1 has hypertrophic and cardioprotective properties . It acts through the leukemia inhibitory factor receptor (LIFR) and glycoprotein 130 (gp130)-coupled signaling pathways .

Expression Patterns: CT-1 is expressed in many tissues, including the heart, vessels, skeletal muscle, prostate, ovary, lung, kidney, pancreas, thymus, testis, and small intestine .

Tissue Distribution: CT-1 is highly expressed in the heart and skeletal muscle, with lower levels in other tissues such as the lung, kidney, and pancreas .

Biological Functions

Primary Biological Functions: CT-1 plays a crucial role in cardiac hypertrophy, cardioprotection, and the healing and remodeling processes following myocardial infarction . It also has roles in fibrosis, hypertension, and diabetes .

Role in Immune Responses and Pathogen Recognition: As a member of the IL-6 superfamily, CT-1 contributes to immune homeostasis and the inflammatory response to infection, trauma, or injury .

Modes of Action

Mechanisms with Other Molecules and Cells: CT-1 exerts its cellular effects by interacting with the gp130/LIFR heterodimer . It activates several intracellular signaling pathways, including the extracellular signal-regulated kinases (ERK), mitogen-activated protein (MAP) kinases, the janus kinase (JAK)/signal transducers and activators of transcription (STAT) system, and PI3-kinase/Akt .

Binding Partners and Downstream Signaling Cascades: CT-1 enhances transcription factor NF-κB DNA-binding activities and activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes .

Regulatory Mechanisms

Transcriptional Regulation: Hypoxia-inducible factor-1 (HIF-1) mediates the up-regulation of CT-1 in response to hypoxic stress . This regulation involves direct interaction with the CTF1 promoter .

Post-Translational Modifications: CT-1 activity is modulated by various post-translational modifications, including phosphorylation and interactions with other signaling molecules .

Applications

Biomedical Research: CT-1 is studied for its role in cardiac hypertrophy, heart failure, and myocardial infarction . It is also investigated for its potential in promoting cardiac repair and wound healing .

Diagnostic Tools: Elevated plasma levels of CT-1 are associated with the severity of hypertrophy in hypertrophic cardiomyopathy and other cardiovascular diseases . CT-1 is considered a potential biomarker for these conditions .

Therapeutic Strategies: CT-1 is explored as a therapeutic target for treating heart failure, myocardial infarction, and other cardiovascular diseases . Its cardioprotective properties make it a promising candidate for developing new treatments .

Role in the Life Cycle

Development: CT-1 plays a role in normal cardiac development and the protection of cardiac myocytes from ischemic and reperfusion injury .

Aging and Disease: CT-1 expression increases in response to cardiac stress and contributes to the healing and remodeling processes in aging and diseased hearts . It is involved in the pathogenesis of various cardiovascular diseases, including heart failure, hypertension, and diabetes .

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