BMP 2 Human, Monomer

Bone Morphogenetic Protein-2 Human Recombinant, Monomer

Produced in E. coli, Recombinant Human Bone Morphogenetic Protein-2 is a non-glycosylated polypeptide chain that exists in a monomeric state. It comprises 115 amino acids (spanning positions 283 to 396) and exhibits a molecular weight of 13009 Daltons. The purification of BMP-2 is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16256
Source
Escherichia Coli.
Appearance
The solution is sterile, filtered, and colorless.

BMP 2 Protein Human

Bone Morphogenetic Protein-2 Human Recombinant

Recombinant Human Bone Morphogenetic Protein-2, produced in E. coli, is a non-glycosylated homodimeric polypeptide. It consists of two chains, each comprising 115 amino acids, resulting in a molecular weight of 26kDa. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16329
Source
Escherichia Coli.
Appearance
Sterile, white, lyophilized powder.

BMP 4 Human

Bone Morphogenetic Protein-4 Human Recombinant

Recombinant Human Bone Morphogenetic Protein-4, produced in E. coli, is a monomeric, non-glycosylated polypeptide chain consisting of 116 amino acids with a molecular weight of 13 kDa. The purification of BMP-4 is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT16424
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

BMP 5 Human

Bone Morphogenetic protein-5 Human Recombinant

Recombinant human BMP-5 is produced in E. coli as a single, non-glycosylated polypeptide chain comprising 139 amino acids (residues 317-454). It has a molecular weight of 15.7 kDa and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT16477
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile-filtered solution.

BMP 2 Human, HEK

Bone Morphogenetic protein-2 Human Recombinant, HEK

Recombinant Human BMP-2, produced in HEK cells, is a glycosylated homodimer with disulfide links. Its molecular weight, ranging around 28kDa, can vary due to glycosylation. The purification process involves proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT16163
Source
HEK.
Appearance
Sterile Filtered White lyophilized powder.

BMP13 Human

Bone Morphogenetic protein-13 Human Recombinant

Recombinant human BMP13, expressed in E. coli, is a non-glycosylated homodimeric protein linked by disulfide bonds. Each subunit comprises 120 amino acids, contributing to a total molecular weight of 27.1 kDa. The protein undergoes purification using proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT16911
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

BMPR1A Human

Bone Morphogenetic Protein Receptor Type IA Human Recombinant

Recombinant human BMPR1A extracellular domain is produced in baculovirus. It is a monomeric, glycosylated polypeptide chain with a C-terminal 6xHis tag. This protein has a molecular weight of 23 kDa.
BMR1A is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT17258
Source
Insect Cells.
Appearance
Sterile Filtered White lyophilized powder.

BMPR1A Human, CHO

Bone Morphogenetic Protein Receptor-1A Human Recombinant, CHO

Recombinant Human Bone Morphogenetic Protein Receptor-1A, produced in CHO cells, is a glycosylated homodimer. It consists of two chains, each containing 362 amino acids, resulting in a total molecular mass of 80.8kDa.

Purification of BMPR1A is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT17341
Source

CHO cells.

Appearance
Sterile Filtered White lyophilized powder (freeze-dried).

GDF15 Human

Growth and Differentiation Factor 15 Human Recombinant

Recombinant Human GDF15, produced in E. coli, is a non-glycosylated homodimeric protein. Each polypeptide chain consists of 113 amino acids, resulting in a total molecular weight of 24.8 kDa for the dimer. The purification process involves proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT17926
Source
Escherichia Coli.
Appearance
Sterile, white, lyophilized (freeze-dried) powder.

GDF15 Human, His

Growth and Differentiation Factor 15 Human Recombinant, His Tag

Recombinant Human GDF15, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 151 amino acids (residues 195-308). It possesses a molecular weight of 16.7 kDa. However, it's important to note that the molecular weight observed on SDS-PAGE will be higher due to the presence of a 36 amino acid His tag fused at the N-terminus. The protein undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT18043
Source
Escherichia Coli.
Appearance
Clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Bone Morphogenetic Proteins (BMPs) are a group of growth factors and cytokines that belong to the Transforming Growth Factor-Beta (TGF-β) superfamily . They were initially discovered for their ability to induce the formation of bone and cartilage. BMPs are pivotal morphogenetic signals that orchestrate tissue architecture throughout the body . There are over 20 different BMPs, each with specific roles in various biological processes .

Biological Properties

Key Biological Properties: BMPs are multifunctional growth factors involved in bone and cartilage development, embryogenesis, hematopoiesis, and neurogenesis . They stimulate the differentiation of mesenchymal stem cells into osteoblasts, which are essential for bone formation .

Expression Patterns and Tissue Distribution: BMPs are expressed in various tissues, including bone, cartilage, teeth, and kidneys . They are secreted glycoproteins that play crucial roles in developmental processes .

Biological Functions

Primary Biological Functions: BMPs are essential for bone and cartilage development. They induce the formation of bone and cartilage by promoting the differentiation of mesenchymal cells into osteoblasts . BMPs also play roles in cell migration, growth, and differentiation during embryogenesis .

Role in Immune Responses and Pathogen Recognition: BMPs modulate inflammation, angiogenesis, and immune responses, providing biological cues for tissue repair, protection, and regeneration .

Modes of Action

Mechanisms with Other Molecules and Cells: BMPs function by binding to specific receptors on cell surfaces, initiating signaling pathways that result in osteoblast differentiation . They interact with type II and type I serine-threonine kinase receptors and transduce signals through Smad and non-Smad signaling pathways .

Binding Partners and Downstream Signaling Cascades: BMPs bind to their receptors, leading to the phosphorylation of Smad proteins. These phosphorylated Smads form complexes with Smad4, translocate to the nucleus, and regulate the transcription of target genes .

Regulatory Mechanisms

Regulatory Mechanisms: BMP signaling is finely tuned by various mechanisms, including extracellular antagonists, BMP prodomains, and co-receptors . These regulatory mechanisms ensure precise control of BMP activity and signaling outcomes .

Transcriptional Regulation and Post-Translational Modifications: BMP ligands are processed from larger precursor forms by proteases, which cleave the prodomain region away from the functional mature domain . This processing is crucial for the activation and regulation of BMP signaling .

Applications

Biomedical Research: BMPs are extensively studied for their roles in bone and cartilage development, as well as their potential therapeutic applications .

Diagnostic Tools and Therapeutic Strategies: Recombinant human BMPs (rhBMPs) are used in orthopedic applications such as spinal fusions, nonunions, and oral surgery . BMP-2 and BMP-7 are FDA-approved for specific uses . BMPs are also being explored for their potential in treating chronic kidney disease and other conditions .

Role in the Life Cycle

Role Throughout the Life Cycle: BMPs play critical roles from embryonic development to aging and disease. During embryogenesis, BMPs are involved in the formation of bone, cartilage, and other tissues . In adults, BMPs contribute to bone homeostasis, repair, and regeneration . Dysregulation of BMP signaling is associated with various pathological conditions, including cancer and fibrosis .

BMPs are essential for maintaining bone health throughout life, ensuring proper bone remodeling and regeneration . They are also involved in the regulation of osteoclast and osteoblast activity, which is crucial for bone homeostasis .

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