SCGB1A1 Human, His

Uteroglobin Human Recombinant, His Tag

Recombinant Human Uteroglobin, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 80 amino acids. It includes a 10 amino acid N-terminal His tag, resulting in a calculated molecular mass of 9.2kDa.
Shipped with Ice Packs
Cat. No.
BT29830
Source
Escherichia Coli.
Appearance
White, lyophilized powder after filtration.

SCGB1A1 Mouse

Uteroglobin Mouse Recombinant

Recombinant Mouse Uteroglobin, produced in E. coli, is a non-glycosylated, disulfide-linked homodimeric protein. It consists of two amino acid chains, each containing 75 amino acids, resulting in a molecular mass of 16.7 kDa. The purification of SCGB1A1 is achieved using specialized chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29908
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

SCGB1A1 Rat

Uteroglobin Rat Recombinant

Recombinant SCGB1A1 from Rat, produced in E. coli, is a non-glycosylated homodimeric polypeptide chain. It consists of two units, each containing 77 amino acids, resulting in a molecular weight of 17.0 kDa.
Shipped with Ice Packs
Cat. No.
BT29971
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

SCGB1A1 Human

Uteroglobin Human Recombinant

Recombinant Human Uteroglobin, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 70 amino acids. With a molecular weight of 15.8 kDa, SCGB1A1 undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29768
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.
Definition and Classification

Uteroglobin, also known as blastokinin or secretoglobin family 1A member 1 (SCGB1A1), is a small, secreted, disulfide-bridged dimeric protein found exclusively in mammals . It is the founding member of the secretoglobin family and is encoded by the SCGB1A1 gene . This protein is multifunctional and is known by various names depending on the tissue and species, such as club-cell secretory protein (CCSP), Clara-cell 16 kD protein, and polychlorinated biphenyl-binding protein (PCB-BP) .

Biological Properties

Key Biological Properties: Uteroglobin is a steroid-inducible protein with anti-inflammatory and immunomodulatory properties . It inhibits soluble phospholipase A2 activity and binds hydrophobic ligands such as progesterone, retinols, and phospholipids .

Expression Patterns: Uteroglobin is expressed in the mucosal epithelia of organs that communicate with the external environment, such as the lungs, uterus, and gastrointestinal tract . It is also present in the blood, urine, and other body fluids .

Tissue Distribution: The protein is specifically expressed in club cells in the lungs and is also found in the endometrium, tracheo-bronchial, gastrointestinal, prostatic, and seminal vesicular epithelium .

Biological Functions

Primary Biological Functions: Uteroglobin plays a crucial role in modulating immune responses and has anti-inflammatory, antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities . It inhibits platelet aggregation and the migration and invasion of normal and cancer cells .

Role in Immune Responses: Uteroglobin’s immunomodulatory functions include inhibiting the production of pro-inflammatory cytokines and regulating the stability of mRNA . It also has a tolerogenic effect on blastomeres and spermatozoa, protecting them from recognition by maternal lymphocytes .

Pathogen Recognition: Uteroglobin binds and sequesters pro-inflammatory lipid mediators, thereby reducing inflammation and aiding in pathogen recognition .

Modes of Action

Mechanisms with Other Molecules and Cells: Uteroglobin interacts with various molecules, including phospholipids and polychlorinated biphenyls, and inhibits phospholipase A2 activity . It also functions via a putative receptor-mediated pathway that is not yet fully defined .

Binding Partners: The protein binds to hydrophobic ligands such as progesterone, retinols, and phospholipids . It also interacts with receptors on the surface of cells, initiating downstream signaling cascades .

Downstream Signaling Cascades: Uteroglobin’s interaction with its receptors triggers signaling pathways that regulate immune responses and inflammation .

Regulatory Mechanisms

Expression and Activity Control: The expression of uteroglobin is regulated by steroid hormones, particularly progesterone . In the respiratory tract, its synthesis is controlled by glucocorticoids .

Transcriptional Regulation: The SCGB1A1 gene is regulated by ovarian steroids, with progesterone playing a significant role in its expression in the endometrium . Nonsteroid hormones like prolactin also augment its expression .

Post-Translational Modifications: Uteroglobin undergoes post-translational modifications, including disulfide bond formation, which is crucial for its dimeric structure and function .

Applications

Biomedical Research: Uteroglobin is studied for its anti-inflammatory and immunomodulatory properties, making it a potential target for drug development .

Diagnostic Tools: Antibodies against uteroglobin are used in various diagnostic applications, including Western Blot, Immunohistochemistry, ELISA, and Flow Cytometry .

Therapeutic Strategies: Due to its anti-inflammatory and antiallergic properties, uteroglobin is being explored as a therapeutic agent for treating inflammatory and autoimmune diseases .

Role in the Life Cycle

Development to Aging and Disease: Uteroglobin plays a critical role throughout the life cycle, from embryonic development to aging . Its expression is crucial during early pregnancy for embryo implantation and growth . In aging, its anti-inflammatory properties help mitigate oxidative damage and inflammation .

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