RELM a Mouse

RELM-alpha Mouse Recombinant

Recombinant Mouse RELM-alpha, produced in E. coli, is a monomeric polypeptide chain that lacks glycosylation. It comprises 88 amino acids, resulting in a molecular weight of 10 kDa. The purification of Mouse RELM-alpha is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT20189
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

RELM a Mouse, His

RELM-Alpha Mouse Recombinant, His Tag

Recombinant Mouse RELM-alpha is designed with a phage fd signal sequence (20aa) and a C-terminal fusion of flagTag (10aa). The resulting RELM-alpha Flag-Tagged Fusion Protein has a molecular weight of 13.3 kDa and comprises 91 amino acid residues of the target protein along with 30 additional amino acid residues from the phage fd signal sequence and the flagTag (underlined).
Shipped with Ice Packs
Cat. No.
BT20300
Source
Escherichia Coli.
Appearance
White lyophilized powder after filtration.

RELM b Human

RELM-Beta Human Recombinant

Recombinant Human RELM-b, produced in E. coli, is a non-glycosylated, disulfide-linked homodimer. Each polypeptide chain consists of 89 amino acids, resulting in a total molecular mass of 19 kDa. The purification of RELM-b is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20396
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

RELM b Human, His

RELM-Beta Human Recombinant, His Tag

RELM-beta Human Recombinant, a 11 kDa His-Tagged Fusion Protein, comprises 90 amino acids of human RELM-beta and a 12 amino acid HisTag (underlined).
Shipped with Ice Packs
Cat. No.
BT20481
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered.

RELM b Mouse

RELM-Beta Mouse Recombinant

Recombinant Mouse RELM-b, produced in E. coli, is a monomeric, non-glycosylated polypeptide chain with 83 amino acids and a molecular weight of 8.9 kDa. Purification of Mouse RETNLB is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20905
Source
Escherichia Coli.
Appearance
Lyophilized powder with a brownish hue.

RELM g Mouse

RELM-Gamma Mouse Recombinant

Recombinant Mouse RELM g, produced in E. coli, is a non-glycosylated homodimer with two 89 amino acid chains, resulting in a molecular weight of 18.9 kDa. The protein is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT20996
Source

Escherichia Coli.

Appearance
Sterile white lyophilized powder.

RELM g Mouse, His

RELM-Gamma Mouse Recombinant, His Tag

RELM-gamma Mouse Recombinant, a His-Tagged Fusion Protein with a molecular weight of 11 kDa, consists of 86 amino acid residues of the RELM-gamma Mouse and 16 additional amino acid residues corresponding to the HisTag (underlined).
Shipped with Ice Packs
Cat. No.
BT21063
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered.

Resistin Human

Resistin Human Recombinant

Recombinant Human Resistin, produced in E. coli, is a non-glycosylated, homodimeric polypeptide chain. It consists of two chains, each containing 93 amino acids, resulting in a total molecular weight of 19.7 kDa.
The purification of Recombinant Human Resistin is achieved using standardized chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT21135
Source
Escherichia Coli.
Appearance

Filtered White lyophilized (freeze-dried) powder.

Resistin Human, HEK

Resistin Human Recombinant, HEK

Recombinant Human Resistin, produced in HEK293 cells, is a single, glycosylated polypeptide chain containing 96 amino acids (19-108 a.a). It has a molecular weight of 10.3 kDa. This Resistin protein is engineered with a 6 amino acid His-tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21214
Source

HEK293 cells.

Appearance
Clear, colorless solution, sterilized by filtration.

Resistin Human, His

Resistin Human Recombinant, His Tag

Recombinant Human Resistin, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of a 92 amino acid fragment (17-108) of the mature Human Resistin and has a total molecular mass of 14.23 kDa. It is fused to a 4.5 kDa amino-terminal hexahistidine tag.
The purification of Resistin is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21281
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1), is a cysteine-rich peptide hormone derived from adipose tissue. In humans, it is encoded by the RETN gene located on chromosome 19 . Resistin belongs to the family of resistin-like molecules (RELMs), which also includes RELMα, RELMβ, and RELMγ .

Biological Properties

Key Biological Properties: Resistin is a cysteine-rich protein with a molecular weight of approximately 12.5 kDa. It consists of 108 amino acids in humans and 114 amino acids in mice .

Expression Patterns and Tissue Distribution: In humans, resistin is predominantly expressed in immune cells such as monocytes and macrophages, while in rodents, it is primarily secreted by adipocytes . Resistin is found in various tissues, including bone marrow, spleen, and blood .

Biological Functions

Primary Biological Functions: Resistin plays a significant role in regulating glucose metabolism, lipid metabolism, and insulin resistance . It is also involved in inflammatory processes and has been linked to chronic inflammatory diseases, metabolic diseases, infectious diseases, and cancers .

Role in Immune Responses and Pathogen Recognition: Resistin functions as a host defense peptide of innate immunity, exhibiting wide-spectrum antimicrobial activity and modulating immune responses . It limits microbial product-induced inflammation and plays a regulatory role in chronic inflammatory diseases .

Modes of Action

Mechanisms with Other Molecules and Cells: Resistin interacts with various molecules and cells, including endothelial cells, smooth muscle cells, and immune cells . It influences several biological processes such as inflammation, endothelial dysfunction, thrombosis, and angiogenesis .

Binding Partners and Downstream Signaling Cascades: Resistin binds to receptors on target cells, activating signaling pathways such as the NF-κB pathway, which leads to the expression of pro-inflammatory cytokines like interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) . It also affects the phosphorylation state of enzymes like AMPK, influencing glucose metabolism .

Regulatory Mechanisms

Transcriptional Regulation: Resistin expression is regulated by various transcription factors, including PPARγ and C/EBP . These factors influence the transcriptional events leading to the production of resistin in different tissues.

Post-Translational Modifications: Resistin undergoes post-translational modifications that affect its stability and activity. These modifications include disulfide bond formation, which is crucial for its structural integrity and function .

Applications

Biomedical Research: Resistin is extensively studied for its role in metabolic diseases, particularly type 2 diabetes mellitus (T2DM) and obesity . It serves as a biomarker for these conditions and is used to understand the underlying mechanisms of insulin resistance .

Diagnostic Tools: Resistin levels are measured in clinical settings to diagnose and monitor inflammatory diseases and metabolic disorders . It is also explored as a potential diagnostic biomarker for sepsis .

Therapeutic Strategies: Targeting resistin and its signaling pathways is considered a therapeutic strategy for treating metabolic and inflammatory diseases. Inhibitors of resistin activity are being developed to improve insulin sensitivity and reduce inflammation .

Role in the Life Cycle

Development to Aging and Disease: Resistin plays a role throughout the life cycle, from development to aging. It is involved in energy homeostasis, glucose and lipid metabolism, and immune responses . Elevated resistin levels are associated with aging-related diseases such as T2DM, cardiovascular diseases, and chronic inflammatory conditions .

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