Borrelia DbpB

Borrelia Burgdorferi Decorin Binding Protein B Recombinant

Recombinant Borrelia Burgdorferi Decorin Binding Protein B, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular weight of 19,353 Daltons. The protein is engineered with a 6x His tag at the N-terminus and purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT28956
Source
Escherichia Coli.
Appearance
The product appears as a clear, sterile-filtered solution.

Borrelia Garinii DbpA

Borrelia Garinii Decorin Binding Protein A Recombinant

Recombinant Borrelia Garinii Decorin Binding Protein A, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 19kDa. It is expressed with a -10x His tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29044
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

Borrelia Garinii OspC

Borrelia Garinii OspC Recombinant

Recombinantly produced in E.coli, this non-glycosylated polypeptide chain represents Borrelia Garinii Outer Surface Protein C. With a predicted molecular weight of 22kDa, this protein is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT29114
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.

Borrelia Miyamotoi GlpQ

Borrelia Miyamotoi GlpQ Recombinant

Recombinant Borrelia Miyamotoi GlpQ, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 38,132 Daltons. This protein is expressed with a 10xHis tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29171
Source
Escherichia Coli.
Appearance
A clear solution that has been sterile filtered.

Borrelia Spielmanii DbpA

Borrelia Spielmanii Decorin Binding Protein A Recombinant

Recombinant Borrelia Spielmanii Decorin Binding Protein A, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 17kDa.

A -10x His tag is added to the N-terminus of Borrelia Spielmanii DbpA during expression, and purification is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT30108
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

Borrelia Spielmanii OspC

Borrelia Spielmanii Outer Surface Protein C Recombinant

This product consists of recombinant Borrelia Spielmanii Outer Surface Protein C (OspC), produced in E. coli. This non-glycosylated polypeptide has a molecular weight of 24kDa and features a -6x His tag at the N-terminus. It undergoes purification using proprietary chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT30157
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

Borrelia VisE1

Borrelia Burgdorferi VlsE1 Recombinant

Recombinant Borrelia VisE1, a non-glycosylated polypeptide chain with a predicted molecular weight of 43kDa, is generated by expressing the variable major protein-like sequence E1 in E.coli. This recombinant protein is further modified by the addition of a 10x His tag at the N-terminus and purified using specialized chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT30210
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized through filtration.

Borrelia Bavariensis VlsE1

Borrelia Bavariensis VlsE1 Recombinant

Recombinant Borrelia Bavariensis VlsE1, also known as variable major protein-like sequence E1, is produced in E. coli. This non-glycosylated polypeptide chain has an estimated molecular mass of 28kDa. Notably, it is expressed with a 6x His tag at the N-terminus and undergoes purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT28617
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

Borrelia Bavarriensis 58

Borrelia Bavariensis p58 Recombinant

Recombinant Borrelia Bavarriens 58, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 61kDa. It is expressed with a -6x His tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28710
Source
Escherichia Coli.
Appearance
Clear solution, sterile filtered.

Borrelia BmpA

Borrelia Burgdorferi Basic Membrane Protein A Recombinant

Recombinant Borrelia Burgdorferi Basic Membrane Protein A, produced in E.coli, is a non-glycosylated polypeptide chain with a calculated molecular mass of 36,239 Daltons. This protein is expressed with a 6x His tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28775
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.
Definition and Classification

Borrelia is a genus of bacteria belonging to the spirochete phylum. These bacteria are characterized by their spiral shape and are known for causing diseases such as Lyme disease and relapsing fever . Borrelia species are classified under the family Spirochaetaceae and are Gram-negative . The genus Borrelia includes several species, with Borrelia burgdorferi being the most well-known due to its role in causing Lyme disease .

Biological Properties

Key Biological Properties: Borrelia species are microaerophilic and slow-growing . They possess a unique structure with an outer membrane, an inner membrane, and a layer of peptidoglycan in the periplasmic space . These bacteria move using axial filaments called endoflagella, which allow them to propel forward in a corkscrew-like motion .

Expression Patterns and Tissue Distribution: Borrelia species express various outer surface proteins (Osp) that play a role in their virulence . These proteins are differentially expressed depending on the environment, such as within a tick vector or a mammalian host . The bacteria are typically found in the skin, joints, nervous system, and heart of infected hosts .

Biological Functions

Primary Biological Functions: Borrelia species are primarily known for their role in causing Lyme disease and relapsing fever . They can evade the host immune system through antigenic variation, allowing them to persist in the host and cause chronic infections .

Role in Immune Responses and Pathogen Recognition: Borrelia species interact with the host immune system by modulating the expression of surface proteins to avoid detection . They can also inhibit the accumulation of reactive oxygen species (ROS) through the production of superoxide dismutase .

Modes of Action

Mechanisms with Other Molecules and Cells: Borrelia species interact with host cells through various adhesins and surface proteins . These interactions facilitate the bacteria’s ability to invade and colonize different tissues .

Binding Partners and Downstream Signaling Cascades: The bacteria bind to host cells using specific receptors and initiate signaling cascades that promote their survival and dissemination . For example, Borrelia burgdorferi can bind to integrins on host cells, which helps in their invasion and migration through tissues .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: Borrelia species regulate their gene expression through two-component systems such as HK1/Rrp1 and Rrp2-RpoN-RpoS . These systems control various functions, including metabolism, chemotaxis, and antigenic variation .

Transcriptional Regulation and Post-Translational Modifications: The bacteria use transcriptional regulators to modulate the expression of virulence factors in response to environmental cues . Post-translational modifications, such as phosphorylation, also play a role in regulating the activity of key proteins involved in pathogenesis .

Applications in Biomedical Research

Diagnostic Tools: Borrelia species are detected using serological tests, including immunoassays and immunoblotting . These tests are essential for diagnosing Lyme disease and other Borrelia-related infections .

Therapeutic Strategies: Research on Borrelia has led to the development of antibiotic treatments for Lyme disease . Ongoing studies aim to identify new therapeutic targets and develop vaccines to prevent Borrelia infections .

Role in the Life Cycle

Role Throughout the Life Cycle: Borrelia species have a complex life cycle involving both tick vectors and mammalian hosts . The bacteria are transmitted from infected ticks to mammals during blood meals . In the mammalian host, Borrelia can persist in various tissues and cause long-term infections .

From Development to Aging and Disease: The life cycle of Borrelia involves several stages, including larval, nymphal, and adult stages in ticks . The bacteria can be transmitted at any stage of the tick’s life cycle and remain infectious throughout the tick’s lifespan .

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