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Product List

Chlamydia Pneumonia

Chlamydia Pneumonia Recombinant

This recombinant Chlamydia pneumoniae antigen is produced in E. coli and derived from the VD2-VD3 region of the CP major outer membrane protein, a region specifically recognized by Chlamydia pneumoniae antibodies. It consists of 160 amino acids and has a C-terminal His Tag, resulting in a molecular weight of approximately 21.5 kDa. On SDS-PAGE, the protein exhibits both monomeric and dimeric forms, with the majority forming a dimer that migrates at 42 kDa. The purification process for Chlamydia pneumoniae involves a proprietary chromatographic technique.

Shipped with Ice Packs

Cat. No.

BT625

Source

Escherichia Coli.

Appearance

Clear, colorless solution that has been sterilized by filtration.

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Chlamydia W2

Chlamydia Trachomatis W2 Recombinant

This recombinant protein is derived from E.coli and contains a 6x His fusion at the C-terminus. It encompasses amino acids 66-165 of the Chlamydia Trachomatis MOMP protein.

Shipped with Ice Packs

Cat. No.

BT692

Source

Escherichia Coli.

Chlamidia Trachomatis W3-W6 Recombinant

This recombinant protein is derived from E. coli and contains a 6xHis fusion tag at the C-terminus. It encompasses amino acids 128-398 of the Chlamydia Trachomatis MOMP protein.

Shipped with Ice Packs

Cat. No.

BT797

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Chlamydia W4

Chlamydia Trachomatis W4 Recombinant

This recombinant protein consists of the Chlamydia Trachomatis MOMP protein's epitopes (amino acids 191-286) fused with a 6xHis tag at the C-terminus. It is produced in E.coli.

Shipped with Ice Packs

Cat. No.

BT885

Source

Escherichia Coli.

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Chlamydia W4-W5

Chlamydia Trachomatis W4-W5 Recombinant

The recombinant protein, derived from E. coli, is a 6xHis fusion at the C-terminus. It encompasses the Chlamydia Trachomatis MOMP protein epitopes, specifically amino acids 191 to 354.

Shipped with Ice Packs

Cat. No.

BT1008

Source

Escherichia Coli.

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Introduction

Definition and Classification

Chlamydia is a genus of pathogenic Gram-negative bacteria that are obligate intracellular parasites. The most well-known species within this genus is Chlamydia trachomatis, which is the leading cause of bacterial sexually transmitted infections (STIs) and infectious blindness worldwide. Chlamydia trachomatis is classified under the order Chlamydiales and the family Chlamydiaceae.

Biological Properties

Chlamydia trachomatis exhibits several key biological properties:

Obligate Intracellular Nature: Chlamydia trachomatis can only replicate within host cells.
Biphasic Developmental Cycle: It alternates between two forms: the infectious elementary body (EB) and the replicative reticulate body (RB).
Expression Patterns and Tissue Distribution: Chlamydia trachomatis primarily infects epithelial cells of the genital tract, respiratory tract, and conjunctiva.

Biological Functions

Chlamydia trachomatis plays several critical roles in biological functions:

Primary Biological Functions: It is responsible for causing various diseases, including trachoma, lymphogranuloma venereum, and pelvic inflammatory disease.
Role in Immune Responses: Chlamydia trachomatis can modulate host immune responses to evade detection and destruction.
Pathogen Recognition: The bacteria use specific surface proteins to recognize and bind to host cells.

Modes of Action

Chlamydia trachomatis interacts with host cells through several mechanisms:

Binding Partners: The elementary bodies bind to host cells via adhesins and host receptor proteins.
Downstream Signaling Cascades: Once inside the host cell, Chlamydia trachomatis injects effector proteins that manipulate host cell functions to create a favorable environment for replication.

Regulatory Mechanisms

The expression and activity of Chlamydia trachomatis are controlled by various regulatory mechanisms:

Transcriptional Regulation: The bacteria’s genome encodes transcription factors that regulate gene expression during different stages of the developmental cycle.
Post-Translational Modifications: Chlamydia trachomatis proteins undergo modifications that affect their function and interaction with host cell processes.

Applications

Chlamydia trachomatis has several applications in biomedical research and clinical practice:

Biomedical Research: It serves as a model organism for studying host-pathogen interactions and intracellular parasitism.
Diagnostic Tools: Nucleic acid amplification tests (NAATs) are commonly used to diagnose Chlamydia trachomatis infections.
Therapeutic Strategies: Antibiotics such as azithromycin and doxycycline are effective in treating Chlamydia trachomatis infections.

Role in the Life Cycle

Chlamydia trachomatis plays a crucial role throughout its life cycle:

Development: The bacteria alternate between the infectious elementary body and the replicative reticulate body.
Aging and Disease: Untreated infections can lead to chronic conditions such as pelvic inflammatory disease and infertility.

Chlamydia trachomatis remains a significant pathogen with profound implications for public health. Understanding its biology, mechanisms of action, and regulatory pathways is essential for developing effective diagnostic and therapeutic strategies.