T.pallidum p15 (Partial)

Treponema pallidum p15 (Partial) Recombinant

This recombinant protein, derived from E. coli, is fused with a GST tag at the N-terminus and encompasses the immunodominant regions of Trp. Pallidum p15.
Shipped with Ice Packs
Cat. No.
BT8405
Source
Escherichia Coli.

T.pallidum p15 (Partial), His

Treponema pallidum p15 (Partial) Recombinant, His Tag

This E. coli-derived recombinant protein consists of a 6xHis tag fused to a multimer of T. pallidum p15 immunodominant regions. With a molecular mass of 15 kDa, this fusion protein contains six histidine residues attached to its C-terminus.
Shipped with Ice Packs
Cat. No.
BT8498
Source
Escherichia Coli.

T.pallidum p17

Treponema pallidum p17 Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions of T. Pallidum p17. It comprises beta-galactosidase (114 kDa) fused at its N-terminus.
Shipped with Ice Packs
Cat. No.
BT8555
Source
Escherichia Coli.

T.pallidum p17 (Partial)

Treponema pallidum p17 (Partial) Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions of Trp. Pallidum p17. It features a 6xHis tag fused at its N-terminus.
Shipped with Ice Packs
Cat. No.
BT8671
Source
Escherichia Coli.

T.pallidum p41

Treponema pallidum p41 Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions of the outer membrane T.Pallidum p41 protein. It is engineered with a Beta-galactosidase tag for various applications.
Shipped with Ice Packs
Cat. No.
BT8737
Source
Escherichia Coli.

T.pallidum p15

Treponema pallidum p15 Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions of Trp. Pallidum p15. It features a beta-galactosidase fusion (114 kDa) at its N-terminus.
Shipped with Ice Packs
Cat. No.
BT8322
Source
Escherichia Coli.

Treponema p17 22kDa

Treponema pallidum p17, 22 kDa Recombinant

Recombinant Treponema pallidum p17, a 22kDa protein, is derived from the full-length TP17 gene (139 amino acids). It is produced in E.Coli and features a C-terminal 6xHis tag. This protein, purified using proprietary chromatographic techniques, has an isoelectric point of 8.7.
Shipped with Ice Packs
Cat. No.
BT9578
Source
Escherichia Coli.
Appearance
Sterile Filtered solution.

T.pallidum TmpA partial

Treponema pallidum TmpA (partial) Recombinant

This recombinant protein, derived from E. coli and weighing 68kDa, encompasses the immunodominant regions of Trp. Pallidum TmpA, specifically amino acids 23-41 and 288-325.
Shipped with Ice Packs
Cat. No.
BT9177
Source
Escherichia Coli.

Treponema Mosaic

Treponema pallidum Mosaic Recombinant

Recombinant Treponema pallidum Mosaic is a 38kDa protein comprising TP15, TP17, and TP47 epitopes. Produced in E. coli, it encompasses 382 amino acids and features a C-terminal 6xHis tag. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT9265
Source
Escherichia Coli.
Appearance
Sterile Filtered solution.

Treponema p17 16.4kDa

Treponema pallidum p17, 16.4kDa Recombinant

Recombinant Treponema p17, produced in E.coli, is a polypeptide chain that lacks glycosylation. It has a molecular weight of 16.4kDa and is fused to a His tag at its N-terminus.
Shipped with Ice Packs
Cat. No.
BT9461
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Definition and Classification

Treponema is a genus of spiral-shaped bacteria belonging to the family Spirochaetaceae. These bacteria are characterized by their helical shape and motility. The genus includes both pathogenic and non-pathogenic species. The most notable pathogenic species is Treponema pallidum, which is responsible for diseases such as syphilis, bejel, and yaws .

Biological Properties

Key Biological Properties: Treponema species are helical, tightly coiled, and motile bacteria, ranging from 5–20 µm in length and 0.1–0.4 µm in diameter . They have a thick phospholipid membrane and a very slow rate of metabolism . Treponema pallidum, for instance, lacks a tricarboxylic acid cycle and processes for oxidative phosphorylation, resulting in minimal metabolic activity .

Expression Patterns and Tissue Distribution: Treponema species are obligate parasites, meaning they require a host to survive. They are found in various tissues, including the genitalia, oral cavity, and gastrointestinal tract . Treponema pallidum is known to be transmitted only among humans and baboons .

Biological Functions

Primary Biological Functions: Treponema species play a crucial role in their host’s microbiome. Pathogenic species like Treponema pallidum are responsible for causing chronic diseases such as syphilis .

Role in Immune Responses and Pathogen Recognition: Treponema pallidum has evolved mechanisms to evade the host’s immune system. Its outer membrane proteins (OMPs) are key factors for pathogenesis, persistence, and immune evasion . The relatively low protein content of the outer membrane prevents antigen recognition by the immune system .

Modes of Action

Mechanisms with Other Molecules and Cells: Treponema pallidum interacts with host cells through its outer membrane proteins. These proteins facilitate attachment to host cells and play a role in immune evasion .

Binding Partners and Downstream Signaling Cascades: The outer membrane proteins of Treponema pallidum interact with host cell receptors, initiating signaling cascades that facilitate bacterial invasion and immune evasion .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: The expression of Treponema pallidum’s outer membrane proteins is tightly regulated. This regulation is crucial for the bacterium’s ability to evade the host’s immune system and establish infection .

Transcriptional Regulation and Post-Translational Modifications: The regulatory mechanisms include transcriptional regulation and post-translational modifications of outer membrane proteins, which are essential for the bacterium’s pathogenicity .

Applications in Biomedical Research

Diagnostic Tools: Treponema pallidum’s outer membrane proteins are used as biomarkers for the diagnosis of syphilis . Rapid tests can provide results in a few minutes, facilitating immediate treatment initiation .

Therapeutic Strategies: Research is ongoing to develop vaccines targeting Treponema pallidum’s outer membrane proteins. These vaccines aim to provide immune protection against syphilis .

Role in the Life Cycle

Role Throughout the Life Cycle: Treponema species play a role throughout their host’s life cycle. For instance, Treponema pallidum can be transmitted from mother to baby during childbirth, leading to congenital syphilis . The bacterium’s ability to evade the immune system allows it to persist in the host for extended periods, contributing to chronic disease .

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