Product List

HSV-1 gD

Herpes Simplex Virus-1 gD Recombinant

The E.Coli derived recombinant protein contains the HSV-1 gD immunodominant regions, 266-394 amino acids and fused to a GST-Tag at C-terminus.
Shipped with Ice Packs
Cat. No.
BT18466
Source
Appearance
Sterile Filtered clear solution.

HSV-1 gD (84-175)

Herpes Simplex Virus-1 gD (84-175 a.a.) Recombinant

The E.Coli derived recombinant protein contains the HSV-1 gD (84-175)  immunodominant region.

Shipped with Ice Packs
Cat. No.
BT18534
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HSV-1 gG

Herpes Simplex Virus-1 gG Recombinant

The E.Coli derived recombinant protein contains the HSV-1 gG immunodominant regions, 84-175 amino acids and fused to a GST-Tag at C-terminus.
Shipped with Ice Packs
Cat. No.
BT18593
Source
Appearance
Sterile Filtered clear solution.

HSV-2 gB

Herpes Simplex Virus-2 gB Recombinant

The E.Coli derived HSV-2 gB recombinant protein is fused to a Six histidine tag at C-terminus and has a MW of 82kDa (pI 8.35).
Shipped with Ice Packs
Cat. No.
BT18653
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HSV 2 gG

Herpes Simplex Virus-2 gG

The HSV-2 gG protein is a synthetic protein which containing the HSV-2 gG immunodominant regions.
Shipped with Ice Packs
Cat. No.
BT18400
Source
Appearance
Sterile Filtered clear solution.

HSV-2 gD

Herpes Simplex Virus-2 gD Recombinant

The E.Coli derived 39.7 kDa recombinant protein contains the HSV-2 gD immunodominant regions 266-394 amino acids, fused with 26 kDa GST-tag.
Shipped with Ice Packs
Cat. No.
BT18724
Source
Appearance
Sterile Filtered clear solution.

HSV-2 gD (31-335)

Herpes Simplex Virus-2 gD (31-335 a.a.) Recombinant

E.Coli derived HSV-2 gD recombinant protein, amino acids 31-335.

Shipped with Ice Packs
Cat. No.
BT18809
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HSV-2 gD (525-578)

Herpes Simplex Virus-2 gD (525-578 a.a.) Recombinant

The E.Coli derived recombinant protein contains the HSV-2 gD (525-578)  immunodominant region.
HSV2 gD is fused to a six histidine his tag at c-terminus and purified by proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT18897
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HSV-2 gG

Herpes Simplex Virus-2 gG Recombinant

The E.Coli derived recombinant protein contains the HSV-2 gG immunodominant regions, 525-578 amino acids, the total MW is 32,100 Dalton, fused with 26 kDa GST-tag.
Shipped with Ice Packs
Cat. No.
BT18968
Source
Appearance
Sterile Filtered clear solution.

HSV-2 VP13/14

Herpes Simplex Virus-2 VP13/14 Recombinant

The E.Coli derived HSV-2 VP13/14 recombinant protein, 1-280 amino acids, is fused to a Six histidine tag at C-terminus and has a MW of 31kDa (pI 6.77). 
Shipped with Ice Packs
Cat. No.
BT19059
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

Introduction

Definition and Classification

Herpes simplex virus (HSV), commonly known as herpes, is a viral infection caused by the herpes simplex virus. There are two main types of herpes simplex virus: HSV-1 and HSV-2. HSV-1 primarily causes oral herpes, which manifests as cold sores around the mouth, while HSV-2 primarily causes genital herpes . Both types can cause infections in other areas of the body as well.

Biological Properties

Herpesviruses are enveloped, double-stranded DNA viruses with relatively large genomes. They replicate in the nucleus of host cells and have a complex structure consisting of a core, capsid, tegument, and envelope . Key biological properties include:

  • Expression Patterns: HSV expresses a large number of enzymes involved in nucleic acid metabolism, DNA synthesis, and protein processing .
  • Tissue Distribution: HSV can infect a wide range of tissues, including the skin, mucous membranes, and nervous system .
Biological Functions

The primary biological functions of HSV include:

  • Immune Responses: HSV can evade the host immune system through various mechanisms, including latency and immune evasion strategies .
  • Pathogen Recognition: HSV is recognized by the host immune system, which mounts a response to control the infection. This includes the activation of innate and adaptive immune responses .
Modes of Action

HSV interacts with host cells through several mechanisms:

  • Binding Partners: HSV binds to host cell receptors using viral glycoproteins, facilitating entry into the cell .
  • Downstream Signaling Cascades: Once inside the cell, HSV hijacks the host’s cellular machinery to replicate and produce new viral particles .
Regulatory Mechanisms

The regulatory mechanisms that control HSV expression and activity include:

  • Transcriptional Regulation: HSV genes are regulated by the host’s transcription machinery, allowing the virus to control its replication cycle .
  • Post-Translational Modifications: HSV proteins undergo various post-translational modifications to enhance their function and evade the host immune system .
Applications

HSV has several applications in biomedical research and therapeutic strategies:

  • Biomedical Research: HSV is used as a model to study viral pathogenesis and immune responses .
  • Diagnostic Tools: HSV infections are diagnosed using PCR, viral culture, and serological tests .
  • Therapeutic Strategies: Antiviral medications, such as acyclovir and valacyclovir, are used to manage HSV infections .
Role in the Life Cycle

HSV plays a significant role throughout its life cycle:

  • Development: HSV establishes latency in sensory neurons after initial infection .
  • Aging and Disease: Reactivation of HSV can occur throughout life, leading to recurrent infections and potential complications, such as encephalitis and neonatal herpes .

Herpes simplex virus remains a significant public health concern due to its widespread prevalence and ability to cause recurrent infections. Ongoing research aims to develop effective vaccines and therapeutic strategies to better manage and prevent HSV infections.

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