HSV 2 gG

Herpes Simplex Virus-2 gG

The HSV-2 gG protein is a synthetically produced protein containing the immunodominant regions of the HSV-2 gG protein.
Shipped with Ice Packs
Cat. No.
BT18400
Appearance
The product is a clear solution that has been sterilized by filtration.

HSV-1 gD

Herpes Simplex Virus-1 gD Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions (amino acids 266-394) of HSV-1 glycoprotein D (gD) and is fused to a C-terminal GST-Tag.
Shipped with Ice Packs
Cat. No.
BT18466
Appearance
The product is a sterile-filtered, clear solution.

HSV-1 gD (84-175)

Herpes Simplex Virus-1 gD (84-175 a.a.) Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant region (amino acids 84-175) of the HSV-1 glycoprotein D (gD).
Shipped with Ice Packs
Cat. No.
BT18534
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

HSV-1 gG

Herpes Simplex Virus-1 gG Recombinant

This recombinant protein is derived from E. coli and contains amino acids 84-175, representing the immunodominant region of HSV-1 gG. It also has a C-terminal GST-tag.
Shipped with Ice Packs
Cat. No.
BT18593
Appearance
The product is a clear, sterile-filtered solution.

HSV-2 gB

Herpes Simplex Virus-2 gB Recombinant

The HSV-2 gB protein, derived from E. coli, is a recombinant protein with a C-terminal Six-histidine tag. It has a molecular weight of 82 kDa and an isoelectric point (pI) of 8.35.
Shipped with Ice Packs
Cat. No.
BT18653
Source
Escherichia Coli.
Appearance
The product is a clear, sterile-filtered solution.

HSV-2 gD

Herpes Simplex Virus-2 gD Recombinant

This recombinant protein, derived from E. coli, has a molecular weight of 39.7 kDa and comprises the immunodominant regions (amino acids 266-394) of HSV-2 gD, fused with a 26 kDa GST-tag.
Shipped with Ice Packs
Cat. No.
BT18724
Appearance
The product is a sterile-filtered, clear solution.

HSV-2 gD (31-335)

Herpes Simplex Virus-2 gD (31-335 a.a.) Recombinant

Recombinant HSV-2 glycoprotein D (gD) comprising amino acids 31-335, expressed in E. coli.
Shipped with Ice Packs
Cat. No.
BT18809
Source
Escherichia Coli.
Appearance
Clear, sterile-filtered solution.

HSV-2 gD (525-578)

Herpes Simplex Virus-2 gD (525-578 a.a.) Recombinant

This recombinant protein consists of the immunodominant region (amino acids 525-578) of HSV-2 glycoprotein D (gD). It is produced in E. coli and purified using proprietary chromatographic methods. A six-histidine tag is fused to the C-terminus to facilitate purification.

Shipped with Ice Packs
Cat. No.
BT18897
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.

HSV-2 gG

Herpes Simplex Virus-2 gG Recombinant

This recombinant protein, derived from E. coli, encompasses the immunodominant regions of HSV-2 gG (amino acids 525-578). With a total molecular weight of 32.1 kDa, it includes a 26 kDa GST-tag.
Shipped with Ice Packs
Cat. No.
BT18968
Appearance
The product is a clear, sterile-filtered solution.

HSV-2 VP13/14

Herpes Simplex Virus-2 VP13/14 Recombinant

This product consists of the Herpes Simplex Virus type 2 (HSV-2) VP13/14 protein, specifically amino acids 1 to 280. It's recombinantly produced in E. coli and includes a C-terminal six-histidine tag for purification. The protein has a molecular weight of 31 kDa and an isoelectric point of 6.77.
Shipped with Ice Packs
Cat. No.
BT19059
Source
Escherichia Coli.
Appearance
The product is a clear solution that has been sterilized by filtration.
Definition and Classification

Herpes simplex virus (HSV), commonly known as herpes, is a viral infection caused by the herpes simplex virus. There are two main types of herpes simplex virus: HSV-1 and HSV-2. HSV-1 primarily causes oral herpes, which manifests as cold sores around the mouth, while HSV-2 primarily causes genital herpes . Both types can cause infections in other areas of the body as well.

Biological Properties

Herpesviruses are enveloped, double-stranded DNA viruses with relatively large genomes. They replicate in the nucleus of host cells and have a complex structure consisting of a core, capsid, tegument, and envelope . Key biological properties include:

  • Expression Patterns: HSV expresses a large number of enzymes involved in nucleic acid metabolism, DNA synthesis, and protein processing .
  • Tissue Distribution: HSV can infect a wide range of tissues, including the skin, mucous membranes, and nervous system .
Biological Functions

The primary biological functions of HSV include:

  • Immune Responses: HSV can evade the host immune system through various mechanisms, including latency and immune evasion strategies .
  • Pathogen Recognition: HSV is recognized by the host immune system, which mounts a response to control the infection. This includes the activation of innate and adaptive immune responses .
Modes of Action

HSV interacts with host cells through several mechanisms:

  • Binding Partners: HSV binds to host cell receptors using viral glycoproteins, facilitating entry into the cell .
  • Downstream Signaling Cascades: Once inside the cell, HSV hijacks the host’s cellular machinery to replicate and produce new viral particles .
Regulatory Mechanisms

The regulatory mechanisms that control HSV expression and activity include:

  • Transcriptional Regulation: HSV genes are regulated by the host’s transcription machinery, allowing the virus to control its replication cycle .
  • Post-Translational Modifications: HSV proteins undergo various post-translational modifications to enhance their function and evade the host immune system .
Applications

HSV has several applications in biomedical research and therapeutic strategies:

  • Biomedical Research: HSV is used as a model to study viral pathogenesis and immune responses .
  • Diagnostic Tools: HSV infections are diagnosed using PCR, viral culture, and serological tests .
  • Therapeutic Strategies: Antiviral medications, such as acyclovir and valacyclovir, are used to manage HSV infections .
Role in the Life Cycle

HSV plays a significant role throughout its life cycle:

  • Development: HSV establishes latency in sensory neurons after initial infection .
  • Aging and Disease: Reactivation of HSV can occur throughout life, leading to recurrent infections and potential complications, such as encephalitis and neonatal herpes .

Herpes simplex virus remains a significant public health concern due to its widespread prevalence and ability to cause recurrent infections. Ongoing research aims to develop effective vaccines and therapeutic strategies to better manage and prevent HSV infections.

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