Growth Factors
Product List
FGF 1 Human, Sf9
Fibroblast Growth Factor-Acidic Human Recombinant, Sf9
FGF 1 Mouse
Fibroblast Growth Factor-Acidic Mouse Recombinant
Recombinant Mouse Fibroblast Growth Factor-acidic (FGF-1), expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 141 amino acids. This protein has a molecular weight of 15.9 kDa.
FGF-acidic is purified using specialized chromatographic techniques.
FGF 1 Mouse, His
Fibroblast Growth Factor-acidic Mouse Recombinant, His Tag
FGF 1 Rat
Fibroblast Growth Factor-Acidic Rat Recombinant
FGF 18 Human
Fibroblast Growth Factor-18 Human Recombinant
A single, non-glycosylated polypeptide chain containing 181 amino acids makes up recombinant human FGF-18 generated in E.coli, which has a molecular weight of 21.1 kDa. Using specialized chromatographic methods, the FGF-18 is purified.
FGF 18 Human, His
Fibroblast Growth Factor-18 Human Recombinant, His Tag
FGF 19 Human, His
Fibroblast Growth Factor-19 Human Recombinant, His Tag
FGF 21 Human
Fibroblast Growth Factor-21 Human Recombinant
Recombinant Human Fibroblast Growth Factor -21, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 181 amino acids with a molecular weight of 19.4 kDa.
Purification of FGF-21 is achieved using proprietary chromatographic methods.
FGF 21 Human, His
Fibroblast Growth Factor-21 Human Recombinant, His Tag
FGF 21 Mouse
Fibroblast Growth Factor-21 Mouse Recombinant
Introduction
Fibroblast Growth Factors (FGFs) are a family of cell signaling proteins produced by macrophages. They play crucial roles in various biological processes, including embryonic development, tissue homeostasis, wound repair, and cancer . FGFs are typically classified into three main groups based on their mechanisms of action: intracrine FGFs, paracrine FGFs, and endocrine FGFs . In humans, there are 23 identified members of the FGF family, each with distinct functions and binding specificities .
FGFs exhibit a wide range of biological properties. They are involved in the regulation of cell proliferation, migration, and differentiation in various tissues, including connective tissues, nerves, epithelial tissue, and bone . FGFs are expressed in different patterns and are distributed across various tissues. For example, FGF1 (acidic FGF) and FGF2 (basic FGF) are widely expressed in many tissues, while others like FGF18 are specifically involved in cartilage development .
The primary biological functions of FGFs include promoting cell growth, differentiation, and survival. They play a significant role in immune responses and pathogen recognition by influencing the behavior of immune cells . FGFs are also involved in the repair and regeneration of tissues, making them key players in wound healing and tissue homeostasis .
FGFs exert their effects by binding to specific fibroblast growth factor receptors (FGFRs) on the cell surface. This binding activates various downstream signaling cascades, including the RAS/MAPK pathway, PI3K/AKT pathway, and PLC-γ pathway . These signaling pathways regulate diverse cellular functions, such as proliferation, differentiation, and migration .
The expression and activity of FGFs are tightly regulated through multiple mechanisms. Transcriptional regulation involves various transcription factors that control the expression of FGF genes . Post-translational modifications, such as phosphorylation and glycosylation, also play a crucial role in modulating the activity and stability of FGFs .
FGFs have numerous applications in biomedical research, diagnostic tools, and therapeutic strategies. They are used in tissue engineering and regenerative medicine to promote the repair and regeneration of damaged tissues . FGFs are also employed in cancer therapy, as they can influence tumor growth and angiogenesis .
Throughout the life cycle, FGFs play essential roles from development to aging and disease. During embryonic development, FGFs are involved in the formation of body axes, morphogenesis, and organogenesis . In adults, they contribute to tissue homeostasis and repair. Dysregulation of FGF signaling is associated with various diseases, including cancer, metabolic disorders, and neurodegenerative diseases .
