Retinol Binding Protein Native Human
This product consists of naturally-produced Human Retinol Binding Protein, isolated from the urine of patients with renal tubular proteinuria. Its molecular weight is approximately 21 kDa.
Urine from the patients with renal tubular proteinuria.
Sterile, white powder, freeze-dried and filtered.
Retinol Binding Protein-1 Human Recombinant
Retinol Binding Protein-2 Human Recombinant
Retinol Binding Protein-3 Human Recombinant
This product is a recombinant human RBP3 protein, specifically the 321-630a.a fragment, produced in E. coli bacteria. It's a single, non-glycosylated polypeptide chain with a 6-amino acid Histidine tag at the N-terminus. The protein is purified using proprietary chromatographic techniques.
Escherichia Coli.
Retinol Binding Protein-4 Human Recombinant
Retinol Binding Protein-4 Human Recombinant, His tag
Retinol Binding Protein-4 Mouse Recombinant, BioActive
Sf9, Baculovirus cells.
Retinol Binding Protein-5 Human Recombinant
Retinol Binding Protein-7 Human Recombinant
Retinol Binding Proteins (RBPs) are a family of proteins that serve as carriers for retinol (vitamin A) in the blood. They belong to the lipocalin family and are crucial for the transport of retinol from the liver to peripheral tissues . RBPs are classified into several types, including plasma retinol-binding protein (RBP4), cellular retinol-binding proteins (CRBP I/II), and cellular retinoic acid-binding proteins (CRABPs) .
Key Biological Properties: RBPs are low-molecular-weight proteins (approximately 21 kDa) that bind retinol with high affinity . They form complexes with transthyretin (TTR) to prevent renal filtration .
Expression Patterns: RBP4 is primarily expressed in the liver, where it binds retinol and is secreted into the bloodstream . Other RBPs, such as CRBP I/II and CRABPs, are expressed in various tissues and are involved in intracellular retinoid transport and metabolism .
Tissue Distribution: RBPs are found in the liver, kidneys, and various other tissues. They are also present in the uterus, embryo, and extraembryonic tissues during pregnancy .
Primary Biological Functions: The main function of RBPs is to transport retinol from the liver to peripheral tissues . Retinol is essential for vision, immune function, reproduction, and cellular differentiation .
Role in Immune Responses and Pathogen Recognition: Retinol and its metabolites play a crucial role in modulating immune responses. They are involved in the regulation of gene expression related to immune cell function .
Mechanisms with Other Molecules and Cells: RBPs bind retinol and form a complex with TTR in the bloodstream . This complex interacts with specific membrane receptors, such as ‘stimulated by retinoic acid 6’ (STRA6), to deliver retinol to target cells .
Binding Partners and Downstream Signaling Cascades: RBPs interact with various binding partners, including TTR and STRA6, to facilitate retinol transport and signaling . The retinol-RBP complex is crucial for maintaining retinoid homeostasis and regulating downstream signaling pathways .
Transcriptional Regulation: The expression of RBPs is regulated by a multiprotein complex involving high mobility group A1, protein-associated splicing factor, and steroidogenic factor 1 . Cyclic AMP stimulation can also induce RBP expression .
Post-Translational Modifications: RBPs undergo various post-translational modifications that affect their stability and function. These modifications include phosphorylation and glycosylation .
Biomedical Research: RBPs are used as biomarkers for assessing vitamin A status and diagnosing renal tubular dysfunction . They are also studied for their role in retinoid homeostasis and related diseases .
Diagnostic Tools: Measurement of RBP levels in blood and urine is used to diagnose and monitor kidney diseases and vitamin A deficiency .
Therapeutic Strategies: RBPs are being explored as potential therapeutic targets for diseases related to retinoid metabolism, such as certain cancers and metabolic disorders .
Development: RBPs are essential for embryonic development, as retinol is crucial for cell differentiation and growth . Proper retinol transport and metabolism are necessary for successful pregnancy and fetal development .
Aging and Disease: RBPs play a role in maintaining retinoid homeostasis throughout life. Dysregulation of RBP expression or function can lead to various diseases, including vision disorders, immune deficiencies, and metabolic syndromes .