Omentin 298 a.a. Human

Omentin 298 a.a. Human Recombinant

Recombinant Human Omentin, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 298 amino acids (17-313). It has a molecular mass of 33.2 kDa and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24766
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

Omentin Human

Omentin Human Recombinant

Recombinant Human Omentin is produced in E. coli using recombinant DNA technology. It is a single polypeptide chain comprising 313 amino acids, resulting in a molecular weight of 35 kDa. The purification process of Intelectin involves proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT24844
Source
E.Coli.
Appearance

The product appears as a sterile, white powder that has been lyophilized (freeze-dried).

Omentin Human, His

Omentin Human Recombinant, His Tag

Recombinant Human Omentin, a 32.7 kDa single polypeptide chain consisting of 294 amino acids, is produced in E. coli using recombinant DNA technology. This protein includes a His tag at the N-terminus and undergoes purification through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT24906
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile filtered.
Definition and Classification

Omentin is an adipokine primarily produced by visceral fat tissue. It has two isoforms, omentin-1 and omentin-2. Omentin-1, also known as intelectin-1, is predominantly secreted by visceral adipose tissue, specifically from the stromal vascular fraction cells of white adipose tissue (WAT) .

Biological Properties

Key Biological Properties: Omentin-1 has anti-inflammatory, antioxidant, and anti-apoptotic properties . It positively impacts endothelial function and prevents atherosclerosis .

Expression Patterns: Omentin-1 is highly expressed in human visceral and epicardial adipose tissues, with lower levels found in other WAT depots such as subcutaneous WAT .

Tissue Distribution: Omentin-1 is primarily produced by the stromal vascular cells of visceral adipose tissue . It is also present in human blood and other WAT depots .

Biological Functions

Primary Biological Functions: Omentin-1 plays a crucial role in glucose homeostasis, atheroprotection, and cardiovascular health . It enhances insulin-stimulated glucose uptake in adipocytes and functions as a vasodilator .

Role in Immune Responses and Pathogen Recognition: Omentin-1 has been implicated in immune responses due to its anti-inflammatory properties .

Modes of Action

Mechanisms with Other Molecules and Cells: Omentin-1 interacts with various molecules and cells to exert its effects. It raises NO metabolites in the aorta and increases the ratio of p-eNOS to total eNOS, facilitating endothelial function .

Binding Partners and Downstream Signaling Cascades: Omentin-1’s ability to restore endothelial function is facilitated by an increase in NO bioavailability . It is necessary to identify the specific receptors and downstream signaling pathways involved in omentin-1-mediated vasodilation and anti-inflammatory action .

Regulatory Mechanisms

Regulatory Mechanisms: Omentin-1’s expression and activity are regulated by various factors, including insulin sensitivity . In lipopolysaccharide-induced macrophages, omentin-1 lowers oxidative stress, mitochondrial dysfunction, and proinflammatory cytokines .

Transcriptional Regulation and Post-Translational Modifications: Understanding the factors involved in omentin-1 regulation is essential for unraveling its complex regulatory mechanisms and potential implications for metabolic and cardiovascular health .

Applications

Biomedical Research: Omentin-1’s positive effects on vascular function suggest potential applications in cardiovascular diseases .

Diagnostic Tools and Therapeutic Strategies: Omentin-1 enhances insulin-stimulated glucose uptake in adipocytes, linking it to obesity and Type 2 Diabetes . It also functions as a vasodilator and plays a protective role during coronary atherosclerosis and hypertension .

Role in the Life Cycle

Role Throughout the Life Cycle: Omentin-1 has been implicated in metabolic regulation, influencing insulin sensitivity and glucose and lipid metabolism . Its anti-inflammatory, antioxidant, and anti-apoptotic properties contribute to its role in various physiological processes throughout the life cycle .

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