Periostin Human

Periostin Human Recombinant

OSF2 His-Tagged Fusion Protein Human, a 75 kDa protein, is produced in E. coli. It consists of 648 amino acid residues of human OSF-2 along with 23 additional amino acid residues, including a HisTag and an Xa-cleavage site.
Shipped with Ice Packs
Cat. No.
BT27876
Source
Escherichia Coli.
Appearance
White lyophilized powder, filtered for purity.

Periostin Human, HEK

Periostin Human Recombinant, HEK

Recombinant Human Periostin, produced in HEK cells, is a single, glycosylated polypeptide chain encompassing amino acids Asn22 to Gln836 (totaling 821 amino acids). It has a calculated molecular mass of 91.8 kDa and incorporates a 6-amino acid His tag at the C-terminus.
Shipped with Ice Packs
Cat. No.
BT27980
Source
HEK 293.
Appearance
White, lyophilized powder after filtration.
Definition and Classification

Periostin, also known as POSTN, PN, or osteoblast-specific factor OSF-2, is a protein encoded by the POSTN gene in humans . It belongs to the matricellular protein family, which are non-structural extracellular matrix (ECM) proteins that regulate various biological processes . Periostin functions as a ligand for integrins, supporting the adhesion and migration of epithelial cells .

Biological Properties

Key Biological Properties: Periostin is a secreted adhesion-related protein produced in the periosteum and periodontal ligaments . It is involved in the regulation of embryonic formation, tissue repair, ECM structure, and the maintenance of bone and teeth .

Expression Patterns: Periostin is expressed at low levels in most adult tissues but is highly expressed in pathological sites such as tumors and inflamed organs . It is also transiently upregulated during cell fate changes, whether related to physiological or pathological alterations .

Tissue Distribution: Periostin is primarily found in collagen-rich connective tissues subjected to mechanical stress, such as heart valves, tendons, and the periodontal ligament .

Biological Functions

Primary Biological Functions: Periostin plays a crucial role in bone and tooth formation and maintenance, cardiac development, and tissue repair . It also regulates the ECM structure and promotes cell adhesion and migration .

Role in Immune Responses and Pathogen Recognition: Periostin is involved in the immune response by interacting with integrins on immune cells, thereby influencing cell signaling pathways that modulate immune functions .

Modes of Action

Mechanisms with Other Molecules and Cells: Periostin interacts with multiple cell-surface receptors, especially integrins, to trigger intracellular signaling pathways . It binds to integrins on cancer cells, activating the Akt/PKB- and FAK-mediated signaling pathways, leading to increased cell survival, invasion, angiogenesis, metastasis, and the epithelial-mesenchymal transition .

Binding Partners and Downstream Signaling Cascades: Periostin binds to integrins αvβ3 and αvβ5, which modulate intracellular signaling pathways such as the PI3K/Akt, Wnt, RhoA/ROCK, NF-κB, MAPK, and JAK pathways .

Regulatory Mechanisms

Transcriptional Regulation: The expression of periostin is regulated by various transcription factors and signaling pathways, including TGF-β, which can induce its expression .

Post-Translational Modifications: Periostin undergoes post-translational modifications that influence its activity and interactions with other ECM proteins and cell-surface receptors .

Applications

Biomedical Research: Periostin is extensively studied in cancer research due to its role in tumor progression and metastasis . It is also investigated in the context of tissue repair and regeneration .

Diagnostic Tools: Elevated levels of periostin in tissues and blood can serve as biomarkers for various pathological conditions, including cancer, fibrosis, and inflammatory diseases .

Therapeutic Strategies: Targeting periostin and its signaling pathways holds potential for developing new therapeutic approaches for cancer, fibrosis, and other diseases .

Role in the Life Cycle

Development: Periostin is essential for embryonic development, particularly in the formation of bones, teeth, and cardiac tissues .

Aging and Disease: Periostin expression is upregulated in response to tissue injury and pathological conditions such as cancer, fibrosis, and inflammatory diseases . It plays a role in tissue remodeling and repair throughout the life cycle .

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