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Growth Factors
Product List
MYDGF Mouse
Myeloid Derived Growth Factor Mouse Recombinant
Recombinant MYDGF protein for mice is produced in E. coli bacteria. It is a single chain of 165 amino acids (specifically, amino acids 25 to 166) with a molecular weight of 18.1 kDa. This protein is not glycosylated, meaning it lacks attached sugar molecules. A 23 amino acid His-tag is attached to the N-terminus of the MYDGF protein to aid in purification, which is carried out using specialized chromatographic methods.
Shipped with Ice Packs 
Cat. No.
BT9212
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized by filtration.
OSTF1 Human
Osteoclast Stimulating Factor-1 Human Recombinant
Recombinant human OSTF1, produced in E. coli bacteria, is a single-chain polypeptide that lacks glycosylation. It consists of 225 amino acids (specifically, amino acids 1 to 217), resulting in a molecular weight of 25.1 kDa. The OSTF1 protein has an 8-amino acid His tag attached to its C-terminus and undergoes purification using specialized chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT9366
Source
Escherichia Coli.
Appearance
The solution is sterile, filtered, and colorless.
PGRN Human
Progranulin Human Recombinant
Recombinant Human Progranulin, produced in HEK cells, is a single, glycosylated polypeptide chain. It consists of 1-593 amino acids and has a molecular weight of 74 kDa. The purification of Progranulin is achieved through standard chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT9433
Source
HEK 293 cells.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
AREG Human
Amphiregulin Human Recombinant
Recombinant Human Amphiregulin (AREG) is a single, non-glycosylated polypeptide chain produced in E. coli. It contains 98 amino acids and has a molecular mass of 11.3 kDa. AREG is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT8947
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
BMP8B Human
Bone Morphogenetic protein-8b Human Recombinant
Recombinant Human BMP8B, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 162 amino acids (264-402a.a.). With a molecular weight of 18.1kDa, this protein features a 23 amino acid His-tag at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
LFA 3 Human
Lymphocyte Function Associated Antigen-3 Human Recombinant , Fusion Protein
Recombinant Human Lymphocyte Function-Associated Antigen-3 Fusion Protein is generated using recombinant DNA technology within a Chinese Hamster Ovary (CHO) mammalian cell expression system. This protein has a molecular weight of 91.4 kDa and undergoes purification through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT9103
Source
Chinese Hamster Ovary.
Appearance
Sterile Filtered White Lyophilized Powder
Introduction
Definition and Classification
Growth factors are naturally occurring proteins capable of stimulating cellular growth, proliferation, healing, and cellular differentiation. They play crucial roles in various biological processes. Other growth factors refer to those that do not fall under the well-known categories like epidermal growth factor (EGF), fibroblast growth factor (FGF), or transforming growth factor (TGF). These include factors like hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF).
Biological Properties
- Key Biological Properties: Other growth factors are involved in cell signaling, promoting cell survival, proliferation, and differentiation. They often act in a paracrine or autocrine manner.
- Expression Patterns: These growth factors are expressed in various tissues and organs, often in response to specific physiological needs or injury.
- Tissue Distribution: For example, HGF is primarily produced by mesenchymal cells, VEGF by endothelial cells, and PDGF by platelets and endothelial cells.
Biological Functions
- Primary Biological Functions:
- HGF: Promotes liver regeneration, cell motility, and morphogenesis.
- VEGF: Stimulates angiogenesis (formation of new blood vessels).
- PDGF: Involved in wound healing and the development of blood vessels.
- Role in Immune Responses: These growth factors can modulate immune responses by influencing the behavior of immune cells.
- Pathogen Recognition: Some growth factors can enhance the ability of immune cells to recognize and respond to pathogens.
Modes of Action
- Mechanisms with Other Molecules and Cells: Growth factors bind to specific receptors on the surface of target cells, initiating a cascade of intracellular signaling.
- Binding Partners: Each growth factor has specific receptors, such as the c-Met receptor for HGF, VEGFR for VEGF, and PDGFR for PDGF.
- Downstream Signaling Cascades: Activation of these receptors triggers signaling pathways like the MAPK/ERK pathway, PI3K/AKT pathway, and JAK/STAT pathway, leading to various cellular responses.
Regulatory Mechanisms
- Control of Expression and Activity: The expression of growth factors is tightly regulated at the transcriptional level by various transcription factors and signaling molecules.
- Transcriptional Regulation: Factors like hypoxia-inducible factor (HIF) can upregulate VEGF expression under low oxygen conditions.
- Post-Translational Modifications: Growth factors can undergo modifications such as phosphorylation, glycosylation, and proteolytic cleavage, affecting their activity and stability.
Applications
- Biomedical Research: Growth factors are used to study cell signaling, development, and disease mechanisms.
- Diagnostic Tools: Levels of certain growth factors can serve as biomarkers for diseases like cancer and cardiovascular conditions.
- Therapeutic Strategies: Growth factors are used in regenerative medicine, such as HGF for liver regeneration, VEGF for promoting angiogenesis in ischemic tissues, and PDGF in wound healing therapies.
Role in the Life Cycle
- Development: Growth factors are crucial during embryonic development, guiding the formation of tissues and organs.
- Aging: The activity of growth factors can decline with age, contributing to reduced tissue regeneration and repair.
- Disease: Dysregulation of growth factors is associated with various diseases, including cancer, where overexpression can lead to uncontrolled cell proliferation, and chronic wounds, where insufficient growth factor activity impairs healing.
