Growth Factors CD Antigens Enzymes Viral Antigens Recombinant Proteins Natural Proteins Monoclonal Antibodies Cytokines Polyclonal Antibodies Neurotrophins Chemokines Hormones Custom Antibodies Modified Histone Antibodies Tag/Control Antibodies Antibody Pairs Secondary Antibodies Small Molecular Antibodies Recombinant Antibodies ChIP Antibodies

Growth Factors

HDGF

CSF

Prolactin PRL

RANK Ligand

Retinol Binding Protein

Stem Cell Factor

CTGF

Transforming Growth Factor

EGF

Epigen

Erythropoietin

VEGF Protein

Fibroblast Growth Factor

Other Growth Factors

Galectin

Growth Hormone

Hepatocyte Growth Factor

IGFBP

Insulin-Like Growth Factor

Insulin

Keratinocyte Growth Factor

Leptin

Macrophage Migration Inhibitory Factor

Melanoma Inhibitory Activity

Myostatin

Noggin

NOV

Omentin

Oncostatin-M

Osteopontin

Osteoprotegerin

PDGF

Periostin

Placental Growth Factor

Placental Lactogen

Product List

HDGF Human

Hepatoma-Derived Growth Factor Human Recombinant

Recombinant Human HDGF is a non-glycosylated polypeptide chain, comprising 100 amino acids and having a molecular mass of 11.5 kDa. The protein is expressed in E. coli and purified using proprietary chromatographic techniques, resulting in a highly pure form of the protein.

Shipped with Ice Packs

Cat. No.

BT15405

Source

Escherichia Coli.

Appearance

Clear, sterile-filtered solution.

View Details

HDGF2 Human

Hepatoma-Derived Growth Factor-2 Human Recombinant

Recombinant human HDGF2, expressed in E. coli, is a single, non-glycosylated polypeptide chain. This protein consists of 227 amino acids, with amino acids 1-203 representing the HDGF2 sequence, resulting in a molecular weight of 25.1 kDa. Please note that the molecular weight observed on SDS-PAGE may be higher. This discrepancy is due to the protein being fused to a 24 amino acid His-tag at the N-terminus. The purification process involves proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT15483

Source

Escherichia Coli.

Appearance

A clear solution that has been sterilized by filtration.

View Details

HDGFL1 Human

Hepatoma Derived Growth Factor-Like 1 Human Recombinant

Recombinant human HDGFL1, produced in E. coli, is a non-glycosylated polypeptide chain consisting of 274 amino acids (residues 1-251) with a molecular weight of 29.6 kDa. It includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT15559

Source

Escherichia Coli.

Appearance

A clear solution that has been sterilized by filtration.

View Details

Introduction

Definition and Classification

Hepatoma-Derived Growth Factor (HDGF) is a protein encoded by the HDGF gene in humans. It was initially identified as a novel growth factor for hepatoma cells and is also known as high mobility group protein 1-like 2 (HMG-1L2). HDGF belongs to a family of proteins that includes several HDGF-related proteins, which are characterized by their heparin-binding properties and roles in cellular growth and development.

Biological Properties

HDGF exhibits several key biological properties:

Expression Patterns: HDGF is ubiquitously expressed in various non-cancerous tissues, including the liver, kidney, cardiovascular system, and brain.
Tissue Distribution: It is found in both fetal and adult tissues, with higher expression levels observed in certain cancers.
Key Biological Properties: HDGF has mitogenic, angiogenic, and anti-apoptotic activities. It promotes cellular proliferation, differentiation, and migration.

Biological Functions

HDGF plays several primary biological functions:

Cell Growth and Proliferation: HDGF stimulates the growth of various cell types, including hepatoma cells.
Angiogenesis: It induces the formation of new blood vessels, which is crucial for tissue repair and tumor growth.
Anti-Apoptotic Role: HDGF helps in preventing programmed cell death, thereby supporting cell survival.
Role in Immune Responses and Pathogen Recognition: While HDGF’s direct role in immune responses and pathogen recognition is not well-documented, its involvement in cellular growth and repair indirectly supports immune functions.

Modes of Action

HDGF interacts with other molecules and cells through various mechanisms:

Binding Partners: HDGF binds to nucleolin, a protein involved in ribosome biogenesis and cell proliferation.
Downstream Signaling Cascades: HDGF activates several signaling pathways, including the PI3K/AKT and MEK/ERK pathways, which are crucial for cell survival and proliferation.

Regulatory Mechanisms

The expression and activity of HDGF are regulated through multiple mechanisms:

Transcriptional Regulation: HDGF gene expression is controlled by various transcription factors and signaling pathways.
Post-Translational Modifications: HDGF undergoes modifications such as phosphorylation, which can affect its stability and activity.

Applications

HDGF has several applications in biomedical research and clinical practice:

Biomedical Research: HDGF is studied for its role in cancer progression and as a potential therapeutic target.
Diagnostic Tools: HDGF levels can serve as biomarkers for certain cancers, aiding in diagnosis and prognosis.
Therapeutic Strategies: Targeting HDGF or its signaling pathways offers potential therapeutic approaches for treating cancers and other diseases.

Role in the Life Cycle

HDGF plays a role throughout the life cycle, from development to aging and disease:

Development: HDGF is involved in the development of various organs and tissues during embryogenesis.
Aging: Its expression and activity may change with age, influencing tissue repair and regeneration.
Disease: HDGF is implicated in the progression of several cancers and other diseases, making it a critical factor in disease development and progression.