Leptin tA Ovine

Leptin Antagonist Triple Mutant Ovine Recombinant

Leptin Antagonist Triple Mutant Ovine Recombinant is a single, non-glycosylated polypeptide chain with 146 amino acids, including an additional alanine at the N-terminus. It has a molecular mass of approximately 16 kDa. The Leptin protein was mutated, resulting in the L39A/D40A/F41A mutant. This recombinant protein was purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20045
Source
Escherichia coli.
Appearance
White, lyophilized powder.

Leptin Bovine

Leptin Bovine Recombinant

Recombinant Bovine Leptin, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 146 amino acids with a molecular weight of 16 kDa. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20160
Source
Escherichia Coli.
Appearance
Sterile white powder obtained by lyophilization (freeze-drying).

Leptin Chicken

Leptin Chicken Recombinant

Recombinant Leptin Chicken, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 145 amino acids. It has a molecular mass of 16 kDa and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20266
Source
Escherichia Coli.
Appearance
Sterile white powder obtained through lyophilization (freeze-drying).

Leptin Dog

Leptin Dog Recombinant

Leptin Dog Recombinant is a non-glycosylated polypeptide chain containing 146 amino acids, with a molecular weight of 16 kDa. It is produced in E. coli and purified using specialized chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20363
Source
Escherichia Coli.
Appearance
Sterile, white, lyophilized powder.

Leptin Horse

Leptin Horse Recombinant

Recombinant Leptin Horse, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 146 amino acids. This protein, with a molecular weight of 16 kDa, is purified using advanced chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT20447
Source
Escherichia Coli.
Appearance
Sterile, white, lyophilized (freeze-dried) powder.

Leptin Human

Human Leptin

This synthetically produced human Leptin comprises 35 amino acids (spanning positions 22 to 56) and has a molecular weight of 3950.6 Daltons.
Shipped with Ice Packs
Cat. No.
BT20546
Appearance
It appears as a sterile, white powder that has been lyophilized (freeze-dried).

Leptin Human, His

Leptin Human Recombinant, His Tag

Recombinant Human Leptin, produced in E. coli, is a non-glycosylated polypeptide chain consisting of amino acids 48-167. With a molecular weight of 19 kDa, including a 4 kDa His tag, this protein is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT20632
Source
Escherichia Coli.
Appearance
Sterile Filtered White Lyophilized Powder

Leptin Human, N82K

Leptin Human Recombinant, N82K

Leptin N82K Human Recombinant, produced in E. coli, is a single-chain polypeptide that is not glycosylated (meaning it lacks attached sugar molecules). It consists of 146 amino acids, with an additional alanine (Ala) at the beginning of the chain (N-terminus). This protein has a molecular weight of 16 kDa.

The purification of Leptin N82K is achieved using specialized chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT20695
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

Leptin Human, N82K PEG

Leptin N82K Human Recombinant, Pegylated

Pegylated Leptin N82K Human Recombinant, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 146 amino acids, with an added alanine (Ala) at the N-terminus and a 20 kDa polyethylene glycol (PEG) molecule attached to this alanine. While its actual molecular weight is 35.6 kDa, it appears as a 48 kDa protein on SDS-PAGE due to its larger hydrodynamic volume. Gel filtration analysis using Superdex 200 shows it as an over 200 kDa protein. The purification of Pegylated Leptin N82K Human Recombinant is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT20775
Source
Escherichia Coli.
Appearance
White, lyophilized powder, sterile filtered.

Leptin Mouse

Leptin Mouse Recombinant

Recombinant Mouse Leptin, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 147 amino acids. With a molecular weight of 16 kDa, it is purified using proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT20872
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile filtered.
Definition and Classification

Leptin is a hormone predominantly produced by adipocytes (fat cells) and plays a crucial role in regulating energy balance by inhibiting hunger . It is classified as a protein hormone and is encoded by the LEP gene .

Biological Properties

Key Biological Properties: Leptin is a 16-kDa circulating hormone that acts as a major regulator for food intake and energy homeostasis .

Expression Patterns: Leptin is primarily expressed in white adipose tissue but is also produced in smaller amounts by other tissues such as the stomach, placenta, and mammary gland .

Tissue Distribution: Leptin receptors are widely distributed in the brain, particularly in the hypothalamus, as well as in peripheral tissues including the liver, skeletal muscle, and immune cells .

Biological Functions

Primary Biological Functions: Leptin’s main function is to regulate long-term energy balance by inhibiting hunger and controlling energy expenditure . It also plays a role in metabolism, endocrine system regulation, and immune system function .

Role in Immune Responses and Pathogen Recognition: Leptin influences immune responses by modulating the activity of immune cells, including T cells and macrophages . It has been shown to enhance the body’s ability to recognize and respond to pathogens .

Modes of Action

Mechanisms with Other Molecules and Cells: Leptin acts via its receptor, LepRb, on specialized neuronal populations in the brain, mainly in the hypothalamus and brainstem .

Binding Partners: Leptin binds to its receptor LepRb, which is expressed by various cell types in the brain and peripheral tissues .

Downstream Signaling Cascades: Upon binding to its receptor, leptin activates several downstream signaling pathways, including the JAK/STAT pathway, MAP kinase, and PI-3 kinase pathways .

Regulatory Mechanisms

Control of Expression and Activity: Leptin expression and protein levels are regulated by multiple factors, including hormones such as insulin, glucocorticoids, and catecholamines .

Transcriptional Regulation: The transcription of the LEP gene is influenced by various metabolic and hormonal signals .

Post-Translational Modifications: Leptin undergoes post-translational modifications that affect its stability and activity .

Applications

Biomedical Research: Leptin is extensively studied in the context of obesity, diabetes, and metabolic disorders .

Diagnostic Tools: Leptin levels can be measured to assess metabolic health and diagnose conditions such as leptin deficiency .

Therapeutic Strategies: Leptin replacement therapy is used to treat conditions like congenital leptin deficiency and lipodystrophy .

Role in the Life Cycle

Development to Aging and Disease: Leptin plays a critical role throughout the life cycle, from fetal development to aging . It influences growth, reproductive function, and immune responses . Dysregulation of leptin levels is associated with various diseases, including obesity, diabetes, and neurodegenerative disorders .

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