OSM Human

Oncostatin-M Human Recombinant

Recombinant Human Oncostatin-M, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 227 amino acids. With a molecular weight of 26kDa, it undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24976
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

OSM Human, 195 a.a

Oncostatin-M Human Recombinant (195 a.a.)

Recombinant Human Oncostatin-M, produced in E.Coli, is a single, non-glycosylated polypeptide chain composed of 195 amino acids with a molecular weight of 22kDa. The purification process of OSM involves the use of proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25063
Source
Escherichia Coli.
Appearance
White, sterile-filtered lyophilized powder.

OSM Human, 209 a.a

Oncostatin M Human Recombinant (209 a.a.)

Recombinant Human Oncostatin-M (209 a.a.), produced in E.Coli, is a single, non-glycosylated polypeptide chain composed of 209 amino acids. With a molecular weight of 23.9kDa, this purified protein is obtained through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25176
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

OSM Human, His

Oncostatin-M Human Recombinant, His Tag

Recombinant human OSM, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 230 amino acids (residues 26-234) and has a molecular weight of 25.9 kDa. This OSM variant includes a 21 amino acid His-Tag fused to its N-terminus and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT25247
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile filtered solution.

OSM Mouse

Oncostatin-M Mouse Recombinant

Recombinant Mouse Oncostatin M, produced in E. coli, is a single, non-glycosylated polypeptide chain with a molecular weight of 20.4 kDa, comprising 181 amino acids. The purification process of OSM involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25341
Source
Escherichia Coli.
Appearance
White, sterile-filtered lyophilized (freeze-dried) powder.

OSM Rat

Oncostatin-M Rat Recombinant

Recombinant rat OSM, produced in E.coli, is a single, non-glycosylated polypeptide chain. It contains 214 amino acids, with a molecular weight of 24.3kDa. OSM is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25436
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.
Definition and Classification

Oncostatin M (OSM) is a pleiotropic cytokine that belongs to the interleukin-6 (IL-6) family of cytokines . It is closely related to leukemia inhibitory factor (LIF) in both structure and function . OSM is encoded by the OSM gene located on chromosome 22 in humans .

Biological Properties

Key Biological Properties: OSM is known for its cytokine activity, receptor binding, and growth factor activity . It plays a significant role in various biological processes, including immune response, cell proliferation, and inflammation .

Expression Patterns and Tissue Distribution: OSM is expressed in various tissues, including bone marrow cells, monocytes, blood, nasal epithelium, appendix, granulocytes, gallbladder, and spleen . It is also found in the central nervous system (CNS), where it interacts with CNS resident cells .

Biological Functions

Primary Biological Functions: OSM is involved in hematopoiesis, neuropoiesis, inflammation, bone remodeling, muscle proliferation, and embryonic development . It also plays a role in immune responses and pathogen recognition .

Role in Immune Responses and Pathogen Recognition: OSM is crucial in the immune system’s communication and signaling, particularly in the CNS . It helps in the regulation of inflammatory responses and immune surveillance .

Modes of Action

Mechanisms with Other Molecules and Cells: OSM primarily activates the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes .

Binding Partners and Downstream Signaling Cascades: OSM binds to receptors via two binding sites named site II and site III . It signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, while the type II receptor is composed of gp130 and OSMR .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: OSM expression and activity are regulated through various signaling pathways, including JAK/STAT, MAPK, JNK, and PI3K/AKT pathways . These pathways are crucial for its role in inflammation, immune response, and cell proliferation .

Transcriptional Regulation and Post-Translational Modifications: OSM’s regulatory mechanisms involve transcriptional regulation and post-translational modifications, which are essential for its diverse biological functions .

Applications

Biomedical Research: OSM is used in research related to liver cancer, where it plays a significant role in inflammation, autoimmunity, and cancer . It is also studied for its role in the tumor microenvironment and its potential as an immunotherapeutic target .

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