PLGF3 Human

Placental Growth Factor-3 Human Recombinant

Recombinant Human PLGF3, produced in E. coli, is a non-glycosylated homodimer consisting of two chains of 204 amino acids each. It has a molecular weight of 45.8 kDa.
Shipped with Ice Packs
Cat. No.
BT28885
Source
Escherichia Coli.
Appearance
White lyophilized powder that has been sterile filtered.

PLGF3 Human, sf9

Placental Growth Factor-3 Human Recombinant, sf9

Recombinantly produced in Spodoptera frugiperda, PLGF3 Human takes the form of a glycosylated homodimer. This protein comprises two chains, each consisting of 203 amino acids (Leu19-Arg221), culminating in a molecular weight of 58kDa. The purification of PLGF-3 is achieved through specialized chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28987
Source
Spodoptera frugiperda.
Appearance
The product appears as a sterile, filtered, and lyophilized powder, white in color.

PLGF1 Human, Sf9

Placental Growth Factor-1 Human Recombinant, Sf9

Recombinant Human Placenta Growth Factor-1, produced in insect cells, is a glycosylated homodimeric polypeptide chain consisting of two chains of 131 amino acids each. Its total molecular mass is approximately 34 kDa. The purification of PLGF-1 is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT28596
Source
Insect Cells.
Appearance
White, sterile-filtered powder in lyophilized (freeze-dried) form.

PLGF2 Human

Placental Growth Factor-2 Human Recombinant

Recombinant Human Placental Growth Factor-2, produced in E. coli, is a homodimer protein that lacks glycosylation. Each polypeptide chain consists of 152 amino acids, linked by disulfide bonds, resulting in a total molecular weight of approximately 34.6kDa.

The purification of PLGF2 is achieved through specific chromatographic techniques developed by the company.

Shipped with Ice Packs
Cat. No.
BT28658
Source

Escherichia Coli.

Appearance

The product appears as a sterile, white powder that has been lyophilized (freeze-dried) and filtered for sterility.

PLGF2 Human, CHO

Placental Growth Factor-2 Human Recombinant, CHO

Recombinant human PLGF2 (amino acids 19-170) is produced in CHO cells. It is a disulfide-linked homodimeric glycoprotein with a molecular weight of 33 kDa. The protein consists of 152 amino acids. Purification of recombinant human PLGF2 is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT28736
Source
Chinese Hamster Ovary cells (CHO).
Appearance
The product is a sterile, white, lyophilized powder.

PLGF2 Human, HEK

Placental Growth Factor-2, HEK Human Recombinant

Recombinant human PLGF2, produced in HEK293 cells, is a single glycosylated polypeptide chain encompassing amino acids 19-170. This protein comprises 158 amino acids, resulting in a molecular mass of 18.1 kDa. A 6-amino acid His tag is fused to the C-terminus of PLGF2. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28805
Source

HEK293 cells.

Appearance
Sterile Filtered colorless solution.

PLGF Human, HEK

Placental Growth Factor Human Recombinant

Recombinant Human PLGF, produced in HEK293 cells, is a single, glycosylated polypeptide chain comprising 160 amino acids (a.a 21-170). It has a molecular weight of 18.3kDa. The PLGF protein is fused to a 6 amino acid His-tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28219
Source

HEK293 cells.

Appearance
Sterile filtered colorless solution.

PLGF Human, His

Placental Growth Factor Human Recombinant, His Tag

Recombinant human PLGF1, expressed in E. coli bacteria, is a single polypeptide chain consisting of 123 amino acids (a.a 19-131). This non-glycosylated protein includes a 10 amino acid His tag at its N-terminal end. The calculated molecular mass of PLGF1 is 13.8kDa.

Shipped with Ice Packs
Cat. No.
BT28301
Source
Escherichia Coli.
Appearance
White powder, obtained after filtration and freeze-drying.

PLGF1 Human

Placental Growth Factor-1 Human Recombinant

Recombinant human PLGF1 (amino acids 21-221) produced in E. coli is a disulfide-linked homodimeric, non-glycosylated polypeptide chain consisting of 129 amino acids with a molecular weight of 29 kDa. The recombinant human PLGF1 protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28356
Source
Escherichia coli.
Appearance
Sterile filtered white lyophilized powder.

PLGF1 Human, 132 a.a.

Placental Growth Factor-1, 132 a.a. Human Recombinant

Recombinant Human Placental Growth Factor-1, produced in E. coli, is a non-glycosylated, disulfide-linked homodimer. Each protein molecule comprises two polypeptide chains, each consisting of 132 amino acids, resulting in a total molecular weight of approximately 29.7kDa. The purification process involves specialized chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT28435
Source

Escherichia Coli.

Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Definition and Classification

Placental Growth Factor (PlGF) is a protein encoded by the PGF gene in humans. It belongs to the vascular endothelial growth factor (VEGF) family, which is crucial for angiogenesis and vasculogenesis, particularly during embryogenesis . PlGF is primarily expressed in the placenta but is also found in other tissues .

Biological Properties

Key Biological Properties: PlGF is a heparin-binding protein that can form homodimers and heterodimers. It binds to receptors such as FLT1/VEGFR-1 and, in some isoforms, to NRP1/neuropilin-1 and NRP2/neuropilin-2 .

Expression Patterns: PlGF is predominantly expressed in the placental trophoblast during pregnancy. It is also expressed in various tissues, including the renal medulla, cardia, pylorus, and others .

Tissue Distribution: PlGF is found in the placenta, heart, lung, thyroid, liver, skeletal muscle, and bone . Its expression is particularly high in the placenta, where it plays a significant role in fetal development .

Biological Functions

Primary Biological Functions: PlGF is involved in angiogenesis, the formation of new blood vessels from pre-existing ones. It promotes the proliferation and migration of endothelial cells . PlGF also plays a role in the recruitment and maturation of bone marrow-derived progenitors involved in the angiogenic process .

Role in Immune Responses and Pathogen Recognition: PlGF has been shown to promote the differentiation and activation of monocyte-macrophage lineage cells, which support the angiogenic stimulus .

Modes of Action

Mechanisms with Other Molecules and Cells: PlGF interacts with receptors such as FLT1/VEGFR-1 and NRP1/neuropilin-1. These interactions trigger downstream signaling cascades that promote angiogenesis and endothelial cell growth .

Binding Partners: PlGF binds to FLT1/VEGFR-1 and, in some isoforms, to NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner .

Downstream Signaling Cascades: The binding of PlGF to its receptors activates signaling pathways that lead to the proliferation and migration of endothelial cells, contributing to angiogenesis .

Regulatory Mechanisms

Transcriptional Regulation: The expression of PlGF is regulated at the transcriptional level. Factors such as hypoxia can induce the expression of PlGF .

Post-Translational Modifications: PlGF is secreted as a glycosylated homodimer. Isoforms PlGF-1 and PlGF-3 are diffusible, while PlGF-2 and PlGF-4 have heparin-binding domains and remain cell membrane-associated .

Applications

Biomedical Research: PlGF is used in research to understand its role in angiogenesis and its potential therapeutic applications .

Diagnostic Tools: PlGF levels in maternal blood are used to predict and diagnose pre-eclampsia, a pregnancy complication characterized by high blood pressure and damage to other organs .

Therapeutic Strategies: PlGF is being explored as a therapeutic target for conditions such as fetal growth restriction and preeclampsia. Gene therapy approaches are being investigated to enhance PlGF expression and improve placental function .

Role in the Life Cycle

Development: PlGF plays a crucial role in embryonic development by promoting angiogenesis and vasculogenesis .

Aging and Disease: Dysregulation of PlGF expression is associated with various diseases, including pre-eclampsia and other pregnancy-related complications . PlGF is also being studied for its potential role in cardiovascular diseases and cancer .

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