KGF 2 His Human

Keratinocyte Growth Factor-2 Human Recombinant, His Tag

Recombinant human KGF-2 is produced in E. coli and consists of a single polypeptide chain of 196 amino acids (residues 38-208). It has a molecular weight of 22.0 kDa. This non-glycosylated protein is fused to a 25-amino acid His-tag at the N-terminus to facilitate purification by chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19298
Source
E.coli.
Appearance
Clear, colorless, and sterile-filtered solution.

KGF 2 Human

Keratinocyte Growth Factor-2 Human Recombinant

Recombinant Human Keratinocyte Growth Factor-2, produced in E. coli, is a single, non-glycosylated polypeptide chain. This protein consists of 170 amino acids (spanning positions 40-208) and has a molecular weight of 19.3 kDa. It shares significant structural similarity and functional overlap with KGF-1 (FGF-7), binding to the same receptor. The production process involves purification using proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT19538
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

KGF 2 Mouse

Keratinocyte Growth Factor-2 Mouse Recombinant

Recombinant mouse KGF-2 is a single, non-glycosylated polypeptide chain produced in E. coli. It contains 173 amino acids and has a molecular weight of 19.5 kDa. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT19617
Source
Escherichia Coli.
Appearance
Sterile white lyophilized (freeze-dried) powder.

KGF 2 Rat

Keratinocyte Growth Factor-2 Rat Recombinant

Recombinant Rat KGF-2, produced in E. coli, is a single-chain polypeptide that lacks glycosylation. It consists of 179 amino acids and has a molecular weight of 20.0 kDa. The purification of KGF-2 is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT19683
Source
Escherichia Coli.
Appearance
White, lyophilized powder, sterile-filtered.

KGF Human

Keratinocyte Growth Factor Human Recombinant

Recombinant human keratinocyte growth factor-1 (KGF-1) is a single, non-glycosylated polypeptide chain consisting of 164 amino acids. Produced in E. coli, it has a molecular mass of 18995 Daltons. This purified form of FGF-7 is obtained through proprietary chromatographic techniques, ensuring its high quality and purity.
Shipped with Ice Packs
Cat. No.
BT19743
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile filtered.

KGF Human, Plant

Keratinocyte Growth Factor Human Recombinant, Plant

Recombinant Human KGF, produced in rice grain (Oryza Sativa), is a single polypeptide chain with an approximate molecular weight of 19.2kDa. The purification of KGF is achieved through specialized chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT19838
Source

Rice Grain

Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

KGF Mouse

Keratinocye Growth Factor Mouse Recombinant

Recombinant Mouse Keratinocyte Growth Factor-1, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 164 amino acids, resulting in a molecular weight of 18.9 kDa. The purification process involves proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT19962
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile.
Definition and Classification

Keratinocyte Growth Factor (KGF), also known as Fibroblast Growth Factor 7 (FGF7), is a member of the fibroblast growth factor family. It is a potent mitogen specifically for epithelial cells, including keratinocytes, which are the predominant cell type in the epidermis . KGF is produced by mesenchymal cells and acts predominantly in a paracrine manner .

Biological Properties

Key Biological Properties: KGF is a small signaling molecule that binds to the fibroblast growth factor receptor 2b (FGFR2b) . It regulates the migration and differentiation of epithelial cells and protects them from various insults under stress conditions .

Expression Patterns and Tissue Distribution: KGF is produced by mesenchymal cells and its receptor, FGFR2-IIIb, is expressed by various epithelial cells, including epidermal keratinocytes, intestinal epithelial cells, and hepatocytes . After acute injury, KGF expression is strongly up-regulated in various tissues, including the skin and bladder .

Biological Functions

Primary Biological Functions: KGF plays a crucial role in wound healing by promoting the proliferation, migration, and differentiation of epithelial cells . It also helps in protecting epithelial cells from damage and stress .

Role in Immune Responses and Pathogen Recognition: While KGF’s primary role is in epithelial cell regulation, it indirectly supports immune responses by maintaining the integrity of epithelial barriers, which are the first line of defense against pathogens .

Modes of Action

Mechanisms with Other Molecules and Cells: KGF exerts its biological effects by binding to its high-affinity receptor, FGFR2-IIIb . This binding triggers downstream signaling cascades that promote cell proliferation, migration, and differentiation .

Binding Partners and Downstream Signaling Cascades: The interaction between KGF and FGFR2-IIIb activates several downstream signaling pathways, including the MAPK/ERK pathway, which is crucial for cell proliferation and survival .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: KGF expression is regulated by various factors, including endocrine hormones such as estrogen and LH . These hormones can stimulate KGF gene expression in mesenchymal cells .

Transcriptional Regulation and Post-Translational Modifications: The transcriptional regulation of KGF involves various signaling molecules and pathways that respond to cellular stress and injury . Post-translational modifications, such as phosphorylation, also play a role in modulating KGF activity .

Applications

Biomedical Research: KGF is widely studied for its role in epithelial cell biology and wound healing . It is also being evaluated for its potential in treating conditions like oral mucositis resulting from cancer chemoradiotherapy .

Diagnostic Tools and Therapeutic Strategies: KGF has potential applications in developing diagnostic tools for epithelial cell-related conditions and therapeutic strategies for enhancing wound healing and protecting epithelial tissues .

Role in the Life Cycle

Role Throughout the Life Cycle: KGF plays a vital role throughout the life cycle, from development to aging and disease . During development, it supports the growth and differentiation of epithelial tissues . In adulthood, it helps maintain epithelial integrity and promotes wound healing . In aging and disease, KGF expression can be altered, affecting tissue repair and regeneration .

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