GH Carp

Growth Hormone Carp Recombinant

Recombinant Carp Growth Hormone, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 188 amino acids, resulting in a molecular weight of 21,408 Daltons. The purification of Carp Growth Hormone is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT12196
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

GH Chicken

GH Chicken Recombinant

Recombinant Chicken GH, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 191 amino acids. It includes an additional Alanine residue at the N-terminus, resulting in a molecular weight of 22255 Daltons. Purification of recombinant Chicken GH is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT12279
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.

GH Mouse

GH Mouse Recombinant

Recombinant Mouse Growth Hormone, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 190 amino acids. This protein has a molecular weight of 22 kDa. Mouse GH undergoes purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT13587
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

GH Ovine

Growth Hormone Ovine Recombinant

Recombinant Ovine Growth Hormone, produced in E.Coli, is a single, non-glycosylated polypeptide chain comprised of 200 amino acids, with a molecular weight of 22015 Daltons. The purification of Recombinant Ovine GH is achieved using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT13678
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

GH Ovine, Placental

Placental Ovine Growth Hormone Recombinant

Recombinant Ovine Placental Growth Hormone, produced in E. coli, is a single-chain polypeptide with 191 amino acids. It is non-glycosylated and has a molecular weight of 21.9 kDa. Purification is achieved using proprietary chromatographic methods. Ovine Placental Growth Hormone differs from pituitary-derived Ovine Growth Hormone by two amino acids: G9R/G63S. This variation gives it higher biological activity compared to pituitary Ovine GH.
Shipped with Ice Packs
Cat. No.
BT13759
Source
Escherichia Coli.
Appearance
White, lyophilized powder, sterile-filtered.

GH Zebrafish

Growth Hormone Zebrafish Recombinant

Recombinant Zebrafish Somatotropin, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 185 amino acids, including an additional alanine (Ala) at the N-terminus, and has a molecular weight of 21.18 kDa. Purification of the recombinant Zebrafish Somatotropin is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT14757
Source
Escherichia Coli.
Appearance
The product appears as a sterile, filtered, white lyophilized (freeze-dried) powder.

GH Zebrafish Mutant

Growth Hormone Mutant Zebrafish Recombinant

Somatotropin Zebrafish Mutant G113R Recombinant, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 185 amino acids, including an additional Alanine at the N-terminus, and has a molecular weight of 21.18 kDa. Purification of the Zebrafish Mutant G113R Recombinant is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT14814
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

GHBP Human

GHBP Human Recombinant

Recombinant human GHBP, produced in E.Coli, is a single, non-glycosylated polypeptide chain composed of 248 amino acids, with a molecular weight of 28107.01 Dalton. GHR is purified using proprietary chromatographic methods.

Shipped with Ice Packs
Cat. No.
BT14868
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized powder.

GHBP Human, His

Growth Hormone Binding Protein Human Recombinant, His Tag

Produced in Sf9 insect cells, GHBP is a single, glycosylated polypeptide chain comprising 254 amino acids (19-264a.a.) with a molecular mass of 29.4 kDa. It features an 8-amino acid His tag at the C-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT14921
Source
Sf9, Insect cells.
Appearance
A sterile, colorless solution that has been filtered.

GH Porcine

Growth Hormone Porcine Recombinant

Recombinant Porcine Somatotropin, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 190 amino acids, with a molecular weight of 21.73 kDa. The purification of Growth Hormone is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT13848
Source
Escherichia Coli.
Appearance
White, sterile-filtered lyophilized (freeze-dried) powder.
Definition and Classification

Growth hormone (GH), also known as somatotropin or human growth hormone (hGH), is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration in humans and other animals . It is secreted by the anterior lobe of the pituitary gland and plays a crucial role in human development . GH is classified as a mitogen, which is specific to certain types of cells .

Biological Properties

Key Biological Properties: GH is a 191-amino acid, single-chain polypeptide . It stimulates protein synthesis, increases fat breakdown, and opposes the action of insulin . GH also stimulates the production of insulin-like growth factor 1 (IGF-1), which mediates many of its growth-promoting effects .

Expression Patterns and Tissue Distribution: GH is synthesized and secreted by somatotropic cells in the anterior pituitary gland . It is released in a pulsatile manner, with surges occurring after the onset of deep sleep . GH receptors are widely distributed in various tissues, including the liver, muscle, and bone .

Biological Functions

Primary Biological Functions: GH stimulates the growth of essentially all tissues of the body, including bone . It plays a vital role in normal physical growth in children, with levels peaking during puberty . GH also promotes lipolysis, increases muscle mass, and enhances protein synthesis .

Role in Immune Responses and Pathogen Recognition: GH has been shown to stimulate immune function, although the exact mechanisms are not fully understood . It is believed to enhance the activity of immune cells and promote the production of cytokines .

Modes of Action

Mechanisms with Other Molecules and Cells: GH exerts its effects by binding to the growth hormone receptor (GHR) on target cells . This binding activates the JAK-STAT signaling pathway, leading to the transcription of GH-responsive genes . GH also stimulates the production of IGF-1, which acts in an autocrine and paracrine manner to promote growth .

Binding Partners and Downstream Signaling Cascades: GH binds to GHR, which then associates with Janus kinase 2 (JAK2), leading to the phosphorylation of both GHR and JAK2 . This activation triggers downstream signaling cascades, including the MAPK and PI3K/AKT pathways .

Regulatory Mechanisms

Regulatory Mechanisms Controlling Expression and Activity: GH secretion is regulated by the hypothalamic hormones growth hormone-releasing hormone (GHRH) and somatostatin . GHRH stimulates GH release, while somatostatin inhibits it . Additionally, GH secretion is influenced by metabolic factors, such as glucose and lipid levels, and peripheral hormones like insulin .

Transcriptional Regulation and Post-Translational Modifications: GH gene expression is regulated by transcription factors, including Pit-1 . Post-translational modifications, such as phosphorylation, also play a role in modulating GH activity .

Applications

Biomedical Research: GH is used in research to study growth disorders and metabolic diseases . It is also employed in experiments to understand its role in cell growth and differentiation .

Diagnostic Tools: GH levels are measured to diagnose growth hormone deficiency (GHD) and acromegaly . GH stimulation tests and IGF-1 measurements are commonly used diagnostic tools .

Therapeutic Strategies: Recombinant human growth hormone (rhGH) is used to treat children with growth disorders and adults with GH deficiency . GH therapy has also been explored for its potential to enhance fertility and improve outcomes in assisted reproductive technologies .

Role in the Life Cycle

Development: GH is essential for normal growth and development in children . It promotes the growth of bones and tissues, leading to increased height and muscle mass .

Aging and Disease: GH levels decline with age, which is associated with decreased muscle mass and increased fat accumulation . GH therapy has been investigated for its potential to counteract some of the effects of aging . Additionally, GH dysregulation is implicated in various diseases, including acromegaly and growth hormone deficiency .

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