Growth Factors
Product List
IGFBP3 Human
IGFBP3 Human Recombinant
Recombinant Human IGFBP3, expressed in E.Coli, is a non-glycosylated polypeptide chain. It comprises 264 amino acids, resulting in a molecular weight of 28806 Daltons. The purification of IGFBP-3 is achieved using proprietary chromatographic methods.
IGFBP3 Human, His
Insulin Like Growth Factor Binding Protein-3 Human Recombinant, His Tag
IGFBP6 (28-240) Human
Insulin Like Growth Factor Binding Protein-6 (28-240 a.a.) Human Recombinant
Introduction
Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins that bind to insulin-like growth factors (IGFs) with high affinity. There are six distinct types of IGFBPs in vertebrates: IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, and IGFBP-6 . These proteins play a crucial role in regulating the availability and activity of IGFs by extending their half-life and modulating their interaction with IGF receptors .
Key Biological Properties: IGFBPs are present in all biological fluids and have a molecular weight ranging from 24 to 45 kDa . They share significant sequence homology and have binding affinities for IGF-I and IGF-II .
Expression Patterns: The expression of IGFBPs varies across different tissues and developmental stages. For example, IGFBP-3 is the most abundant and accounts for 80% of all IGF binding .
Tissue Distribution: IGFBPs are widely distributed in various tissues, including the liver, prostate, and other organs . Their expression can be influenced by physiological conditions and disease states .
Primary Biological Functions: IGFBPs regulate the bioavailability of IGFs, thereby influencing cell growth, proliferation, differentiation, and survival . They can either enhance or inhibit IGF signaling depending on the context .
Role in Immune Responses and Pathogen Recognition: IGFBPs have been shown to modulate immune responses and may play a role in pathogen recognition . They can influence the activity of immune cells and the production of cytokines .
Mechanisms with Other Molecules and Cells: IGFBPs interact with IGFs to regulate their access to IGF receptors . They can also bind to other cell surface receptors, such as integrins and transforming growth factor β (TGF-β) family receptors .
Binding Partners and Downstream Signaling Cascades: IGFBPs can modulate signaling cascades by interacting with various binding partners, including intracellular ligands and nuclear hormone receptors . These interactions can influence gene transcription and cellular functions .
Regulatory Mechanisms: The expression and activity of IGFBPs are controlled by various regulatory mechanisms, including transcriptional regulation and post-translational modifications . Phosphorylation, glycosylation, and proteolysis are some of the post-translational modifications that can affect IGFBP function .
Biomedical Research: IGFBPs are used as biomarkers in cancer research and other diseases . They can provide insights into disease progression and prognosis .
Diagnostic Tools: IGFBPs are being explored as diagnostic tools for various conditions, including cancer and metabolic disorders .
Therapeutic Strategies: IGFBPs have potential therapeutic applications, such as targeting IGFBP-3 for cancer treatment . Their ability to modulate IGF signaling makes them attractive candidates for drug development .
Role Throughout the Life Cycle: IGFBPs play a critical role throughout the life cycle, from development to aging . They are involved in various physiological processes, including growth, metabolism, and tissue repair . Dysregulation of IGFBP expression and function can contribute to aging and age-related diseases .
