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Product List
IFN a 2a Human, Plant
Interferon Alpha 2a Human Recombinant, Tobacco
Recombinant Human Interferon Alpha 2a, produced in plants, is a single, glycosylated polypeptide chain with a molecular weight of 19 kDa, comprising 165 amino acids. It features a 6xHis affinity tag at the C-terminus and undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT25991
Source
Nicotiana Sp.Plant.
Appearance
White, sterile-filtered lyophilized powder.
IFN g Human, His
Interferon-Gamma Human Recombinant, His Tag
Recombinant Human IFN-Gamma, expressed in E. coli, is a single, glycosylated polypeptide chain comprising 159 amino acids (24-161 a.a) without cysteine residues. It has a molecular mass of 18.5kDa, confirmed by MALDI-TOF. This IFN-Gamma variant is fused to a 21 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26692
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile-filtered solution.
IFN g Mouse
IFN-Gamma Mouse Recombinant
Recombinant Mouse IFN-gamma, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 134 amino acids. With a molecular weight of 15.6 kDa, this IFN-gamma undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26757
Source
Escherichia Coli.
Appearance
Sterile Filtered White Lyophilized Powder
IFN g Rat
IFN-Gamma Rat Recombinant
Recombinant Rat IFN-gamma, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 135 amino acids. With a molecular weight of 15.6 kDa (15,609 Daltons), this IFN-gamma variant is purified using proprietary chromatographic techniques to ensure high purity and biological activity.
Shipped with Ice Packs
Cat. No.
BT26852
Source
Escherichia Coli.
Appearance
Sterile Filtered White Lyophilized Powder
IFN tau Ovine
IFN-Tau Ovine Recombinant
Recombinant Ovine IFN-Tau, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 172 amino acids. It has a molecular weight of 19914.7 Daltons. The purification process of IFN-Tau involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26940
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
IFNA1 Human
IFN-Alpha 1 Human Recombinant
Recombinant human IFNA1, produced in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 167 amino acids (residues 24-189), resulting in a molecular weight of 19.5 kDa. The purification process of IFN-alpha 1 involves proprietary chromatographic techniques.
Shipped with Ice Packs
IFNG Mouse, His
Interferon-gamma Mouse Recombinant, His Tag
Recombinant Mouse Interferon-gamma (IFNG), expressed in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 158 amino acids (specifically residues 23-155) and has a molecular weight of 18.2kDa. The IFNG protein includes a 25 amino acid His-tag fused to its N-terminus and undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28250
Source
Escherichia Coli.
Appearance
The product is a clear solution that has been sterilized by filtration.
IFNGR1 Human
IFN Gamma Receptor 1 Human Recombinant
Recombinant Human IFNGR1, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain consisting of 234 amino acids (18-245a.a.). With a molecular mass of 26.6kDa, it migrates at 28-40kDa on SDS-PAGE under reducing conditions. This protein is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28329
Source
Sf9, Baculovirus cells.
Appearance
A sterile, colorless solution.
IFNW1 Human
IFN-Omega 1 Human Recombinant
Recombinant Human IFN-Omega 1, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 172 amino acids, resulting in a molecular weight of 19.9kDa. The purification process involves proprietary chromatographic techniques to ensure the protein's purity.
Shipped with Ice Packs
Cat. No.
BT28408
Source
Escherichia Coli.
Appearance
It appears as a sterile, filtered white powder that has been lyophilized (freeze-dried).
IFNW1 Human, HEK
Interferon-Omega 1 Human Recombinant, HEK
Recombinant human IFNW1 is a single, glycosylated polypeptide chain encompassing amino acids 22-195. With a total of 180 amino acids, it possesses a molecular mass of 20.9 kDa. This protein incorporates a 6-amino acid histidine tag (His-tag) at its C-terminus. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Introduction
Definition and Classification
Interferons (IFNs) are a group of signaling proteins produced and released by host cells in response to the presence of pathogens, such as viruses, bacteria, and parasites . They belong to the larger class of proteins known as cytokines, which are crucial for communication between cells to trigger the protective defenses of the immune system . Interferons are named for their ability to “interfere” with viral replication within host cells .
Interferons are classified into three main types based on the type of receptor through which they signal:
- Type I Interferons: This group includes IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω. They bind to a specific cell surface receptor complex known as the IFN-α/β receptor (IFNAR) .
- Type II Interferons: This group consists of IFN-γ, which binds to the IFN-γ receptor (IFNGR) .
- Type III Interferons: This group includes IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4, which signal through the IFN-λ receptor (IFNLR) .
Biological Properties
Interferons exhibit several key biological properties:
- Expression Patterns: Interferons are produced by various cell types, including leukocytes, fibroblasts, and epithelial cells, in response to viral infections .
- Tissue Distribution: They are distributed across different tissues, with plasmacytoid dendritic cells being prolific producers of IFN-α and IFN-β .
- Key Biological Properties: Interferons induce an antiviral state in cells, enhance the immune response, and regulate cell growth and differentiation .
Biological Functions
Interferons play several crucial roles in the immune system:
- Primary Biological Functions: They inhibit viral replication, activate immune cells such as natural killer cells and macrophages, and increase antigen presentation by up-regulating major histocompatibility complex (MHC) molecules .
- Role in Immune Responses: Interferons are essential for the innate immune response, providing the first line of defense against viral infections .
- Pathogen Recognition: They help in recognizing and responding to pathogens by activating various immune cells and signaling pathways .
Modes of Action
Interferons exert their effects through several mechanisms:
- Binding Partners: They bind to specific receptors on the surface of target cells, initiating a signaling cascade .
- Downstream Signaling Cascades: This binding leads to the activation of various genes that produce antiviral proteins, inhibit viral replication, and modulate the immune response .
- Interaction with Other Molecules and Cells: Interferons interact with other cytokines and immune cells to coordinate a comprehensive immune response .
Regulatory Mechanisms
The expression and activity of interferons are tightly regulated:
- Transcriptional Regulation: Interferon regulatory factors (IRFs) play a crucial role in the transcriptional regulation of interferon genes .
- Post-Translational Modifications: Interferons undergo various post-translational modifications that affect their stability, activity, and interactions with other proteins .
- Control of Expression: The production of interferons is induced by the recognition of viral components through pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) .
Applications
Interferons have several applications in biomedical research and medicine:
- Biomedical Research: They are used to study viral infections, immune responses, and cancer biology .
- Diagnostic Tools: Interferons can be used as biomarkers for certain diseases and infections .
- Therapeutic Strategies: Interferons are used in the treatment of various conditions, including viral infections (e.g., hepatitis B and C), multiple sclerosis, and certain cancers .
Role in the Life Cycle
Interferons play a role throughout the life cycle, from development to aging and disease:
- Development: They are involved in the development of the immune system and the establishment of immune responses .
- Aging: The production and response to interferons can change with age, affecting immune function .
- Disease: Dysregulation of interferon production or signaling can contribute to various diseases, including autoimmune disorders and chronic inflammatory conditions .
