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Product List
IRF 2 Human
IFN Regulatory Factor-2 Human Recombinant
Recombinant Human IFN Regulatory Factor-2, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 133 amino acids (residues 1-113) and a 20 amino acid His Tag. It has a molecular weight of 15 kDa. The IRF2 protein undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT28562
Source
Escherichia Coli.
Appearance
Sterile Filtered colorless solution
IFI30 Human
IFN Gamma-Inducible protein 30 Human Recombinant
Recombinant human IFI30, produced in E. coli, is a single polypeptide chain consisting of 199 amino acids (residues 58-232). It has a molecular weight of 22.5 kDa. The protein includes a 24 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25599
Source
E.coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
IFIT3 Human
IFN-Induced Protein With Tetratricopeptide Repeats 3 Human Recombinant
This product contains a purified version of the human IFIT3 protein. It is produced in bacteria (E. coli) and has a molecular weight of 58.4 kDa. The protein sequence includes amino acids 1-490 of the human IFIT3 protein, followed by a 23 amino acid tag used for purification. The protein is supplied in a solution containing phosphate buffered saline (pH 7.4), 20% glycerol, and 1mM DTT.
Shipped with Ice Packs
IFN b Mouse, His
IFN Beta Mouse Recombinant, His Tag
Recombinant Mouse IFN beta, produced in E. coli, is a single, non-glycosylated polypeptide chain comprising 182 amino acids (22-182 a.a.) with a molecular weight of 22 kDa. A 21 amino acid sequence is fused to the N-terminus of Mouse IFN beta, and the protein is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT26422
Source
Escherichia Coli.
Appearance
A clear, sterile solution without any color.
IFN g Equine
Interferon-Gamma Equine Recombinant
Recombinant Equine Interferon-gamma, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 143 amino acids. With a molecular weight of 16.7 kDa, this purified protein is obtained through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26494
Source
Escherichia Coli.
Appearance
The product appears as a sterile, white powder obtained through lyophilization (freeze-drying).
IFN g Human
IFN-Gamma Human Recombinant
Recombinant Human IFN-gamma, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 144 amino acids. With a molecular weight of 17 kDa, this protein is purified using proprietary chromatographic techniques, ensuring high purity and biological activity.
Shipped with Ice Packs
Cat. No.
BT26617
Source
Escherichia Coli.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
IFNG Canine, His
Interferon-gamma Canine Recombinant, His Tag
Recombinant Canine IFNG, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 166 amino acids, with a sequence spanning from amino acid positions 24 to 166. The protein has a molecular mass of 19.3 kDa. A 23 amino acid His-tag is fused to the N-terminus to facilitate purification, which is carried out using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT27809
Source
Escherichia Coli.
Appearance
A clear and colorless solution that has been sterilized by filtration.
IFNG Feline
Interferon-gamma Feline Recombinant
Recombinant Feline Interferon Gamma (IFNG) is a non-glycosylated protein produced in E. coli. It consists of a single polypeptide chain comprising 167 amino acids, with a molecular weight of 19.3 kDa. The protein sequence encompasses amino acids 24 to 167 of the mature IFNG protein. A 23-amino acid Histidine tag is fused to the N-terminus to facilitate purification. The recombinant IFNG undergoes purification using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT27882
Source
Escherichia Coli.
Appearance
The product appears as a clear, colorless solution that has been sterilized through filtration.
IFNG Human, His Active
Interferon-gamma Human Recombinant, His Tag Active
Recombinant human IFNG produced in E. coli is a single, non-glycosylated polypeptide chain containing 159 amino acids (24-161 a.a). This protein has a molecular mass of 18.4 kDa. The N-terminus of IFNG is fused to a 21 amino acid His-tag. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT27963
Source
Escherichia Coli.
Appearance
Colorless, sterile filtered liquid
IFNG Monkey
Interferon-gamma Recombinant Rhesus Macaque
This product consists of recombinant Interferon-gamma (IFNG) from Rhesus Macaque, produced in E.Coli. It is a non-glycosylated polypeptide chain composed of 142 amino acids, with a molecular weight of approximately 16.8kDa. The purification of IFNG is achieved through proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT28063
Source
Escherichia Coli.
Appearance
This product appears as a sterile, filtered, white lyophilized (freeze-dried) powder.
Introduction
Definition and Classification
Interferons (IFNs) are a group of signaling proteins produced and released by host cells in response to the presence of pathogens, such as viruses, bacteria, and parasites . They belong to the larger class of proteins known as cytokines, which are crucial for communication between cells to trigger the protective defenses of the immune system . Interferons are named for their ability to “interfere” with viral replication within host cells .
Interferons are classified into three main types based on the type of receptor through which they signal:
- Type I Interferons: This group includes IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω. They bind to a specific cell surface receptor complex known as the IFN-α/β receptor (IFNAR) .
- Type II Interferons: This group consists of IFN-γ, which binds to the IFN-γ receptor (IFNGR) .
- Type III Interferons: This group includes IFN-λ1, IFN-λ2, IFN-λ3, and IFN-λ4, which signal through the IFN-λ receptor (IFNLR) .
Biological Properties
Interferons exhibit several key biological properties:
- Expression Patterns: Interferons are produced by various cell types, including leukocytes, fibroblasts, and epithelial cells, in response to viral infections .
- Tissue Distribution: They are distributed across different tissues, with plasmacytoid dendritic cells being prolific producers of IFN-α and IFN-β .
- Key Biological Properties: Interferons induce an antiviral state in cells, enhance the immune response, and regulate cell growth and differentiation .
Biological Functions
Interferons play several crucial roles in the immune system:
- Primary Biological Functions: They inhibit viral replication, activate immune cells such as natural killer cells and macrophages, and increase antigen presentation by up-regulating major histocompatibility complex (MHC) molecules .
- Role in Immune Responses: Interferons are essential for the innate immune response, providing the first line of defense against viral infections .
- Pathogen Recognition: They help in recognizing and responding to pathogens by activating various immune cells and signaling pathways .
Modes of Action
Interferons exert their effects through several mechanisms:
- Binding Partners: They bind to specific receptors on the surface of target cells, initiating a signaling cascade .
- Downstream Signaling Cascades: This binding leads to the activation of various genes that produce antiviral proteins, inhibit viral replication, and modulate the immune response .
- Interaction with Other Molecules and Cells: Interferons interact with other cytokines and immune cells to coordinate a comprehensive immune response .
Regulatory Mechanisms
The expression and activity of interferons are tightly regulated:
- Transcriptional Regulation: Interferon regulatory factors (IRFs) play a crucial role in the transcriptional regulation of interferon genes .
- Post-Translational Modifications: Interferons undergo various post-translational modifications that affect their stability, activity, and interactions with other proteins .
- Control of Expression: The production of interferons is induced by the recognition of viral components through pattern recognition receptors (PRRs) such as Toll-like receptors (TLRs) .
Applications
Interferons have several applications in biomedical research and medicine:
- Biomedical Research: They are used to study viral infections, immune responses, and cancer biology .
- Diagnostic Tools: Interferons can be used as biomarkers for certain diseases and infections .
- Therapeutic Strategies: Interferons are used in the treatment of various conditions, including viral infections (e.g., hepatitis B and C), multiple sclerosis, and certain cancers .
Role in the Life Cycle
Interferons play a role throughout the life cycle, from development to aging and disease:
- Development: They are involved in the development of the immune system and the establishment of immune responses .
- Aging: The production and response to interferons can change with age, affecting immune function .
- Disease: Dysregulation of interferon production or signaling can contribute to various diseases, including autoimmune disorders and chronic inflammatory conditions .
