Cytokines
Product List
IL3RA Mouse
Interleukin-3 Receptor Subunit Alpha Mouse Recombinant
IL4I1 Human
Interleukin-4 Induced-1 Human Recombinant
IL4R Human
Interleukin-4 Receptor Human Recombinant
Produced in Sf9 Baculovirus cells, IL4R is a single, glycosylated polypeptide chain with a molecular mass of 24.7kDa. It comprises amino acids 26-232 of the IL4R protein and is fused to an 8 amino acid His tag at the C-terminus, resulting in a total of 215 amino acids. On SDS-PAGE under reducing conditions, IL4R exhibits multiple bands between 28-40kDa. Purification is achieved through proprietary chromatographic techniques.
IL5 Canine
Interleukin-5 Canine Recombinant
Sf9, Baculovirus cells.
IL5 Human, Sf9
Interleukin-5 Human Recombinant, Sf9
IL5 Mouse, HEK
Interleukin-5 Mouse Recombinant, HEK
Recombinant Mouse IL-5, produced in HEK293 cells, is a single-chain glycoprotein. It consists of 122 amino acids (specifically, amino acids 21 to 133), resulting in a molecular weight of 14.2 kDa. The IL-5 is engineered with a 6-amino acid His tag at the C-terminus to facilitate purification, which is carried out using specialized chromatographic methods.
HEK293 Cells.
A clear, colorless solution that has been sterilized by filtration.
IL5 Mouse, Sf9
Interleukin-5 Mouse Recombinant, Sf9
Sf9, Baculovirus cells.
IL-9 Human, Sf9 Active
Interleukin 9 Human Recombinant, Sf9, Active
Recombinant human IL-9, expressed in Sf9 insect cells using a baculovirus system, is a single, glycosylated polypeptide chain. It consists of 132 amino acids (residues 19-144), with a molecular weight of 14.9 kDa. The IL-9 protein includes a 6-amino acid Histidine tag fused at the C-terminus and is purified using proprietary chromatographic techniques.
sIL 2R Human
Interleukin-2 alpha Soluble Receptor Human Recombinant
sIL 6R Human
Interleukin-6 Soluble Receptor Human Recombinant
Introduction
Interleukins (ILs) are a group of cytokines, which are secreted proteins and signal molecules primarily produced by leukocytes (white blood cells). They play a crucial role in the immune system by mediating communication between cells . The human genome encodes more than 50 interleukins and related proteins . Interleukins are classified based on their structure and function, with common families including IL-1, IL-2, IL-6, and IL-12 .
Key Biological Properties: Interleukins are biologically active glycoproteins derived primarily from activated lymphocytes and macrophages . They induce T-lymphocyte activation and proliferation, augment neutrophil, macrophage, and T-lymphocyte cytotoxicity, and promote B lymphocyte and multilineage bone marrow stem-cell precursor growth and differentiation .
Expression Patterns and Tissue Distribution: Interleukins are produced by various cell types, including immune cells like macrophages and lymphocytes . They are expressed in different tissues, such as the bone marrow, thymus, and other epithelial cells .
Primary Biological Functions: Interleukins modulate the growth, differentiation, and activation of immune cells during inflammatory and immune responses . They play a role in both innate and adaptive immune responses .
Role in Immune Responses and Pathogen Recognition: Interleukins are involved in the regulation of immune responses, inflammatory reactions, and hematopoiesis . They help coordinate the body’s response to infections, inflammation, and other immune challenges .
Mechanisms with Other Molecules and Cells: Interleukins interact with specific cell surface receptors to stimulate target cells . For example, IL-6 controls leucocyte recruitment, determines the activity and maintenance of the inflammatory infiltrate, and drives various innate and adaptive immune responses .
Binding Partners and Downstream Signaling Cascades: Interleukins bind to their respective receptors, triggering downstream signaling pathways such as the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathways . These signaling cascades lead to various cellular responses, including proliferation, differentiation, and cytokine production .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of interleukins are regulated by complex molecular mechanisms. For example, IL-10 production is regulated by metabolic pathways and molecular signals downstream of the IL-10 receptor .
Transcriptional Regulation and Post-Translational Modifications: Interleukins undergo transcriptional regulation and post-translational modifications to ensure proper function. These modifications can include phosphorylation, glycosylation, and cleavage .
Biomedical Research: Interleukins are extensively studied in biomedical research for their roles in immune regulation and disease pathogenesis .
Diagnostic Tools: Interleukins serve as biomarkers for various diseases, aiding in diagnosis and monitoring of disease progression .
Therapeutic Strategies: Interleukins are used in therapeutic strategies, such as cancer immunotherapy and treatment of autoimmune diseases . For example, engineered cytokines from the IL-2 family have shown significant effects in tumor immunotherapy .
Role Throughout the Life Cycle: Interleukins play essential roles throughout the life cycle, from development to aging and disease. They regulate hematopoiesis, immune responses, and inflammation . For instance, IL-5 regulates eosinophil proliferation and differentiation, while IL-1 is involved in inflammatory responses .
