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Product List
TRAIL Human (114-281 a.a.), Active
TRAIL/APO 2 Ligand (114-281 a.a.) Human Recombinant, Active
This product consists of the soluble extracellular domain of human TRAIL, specifically amino acids 114 to 281, produced in E. coli bacteria. This recombinant protein is a single polypeptide chain with a molecular weight of 19.6 kDa. Notably, it lacks glycosylation, a common post-translational modification in eukaryotic cells. The purification process involves proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs 
Cat. No.
BT29625
Source
Escherichia Coli.
Appearance
A clear, colorless liquid that has been sterilized through filtration.
TRAIL Mouse
TNF-Related Apoptosis Inducing Ligand/Apo2L Mouse Recombinant
Recombinant Mouse TRAIL is a single, non-glycosylated polypeptide chain containing 175 amino acids with a molecular weight of 20.2 kDa. It is produced in E. coli.
Shipped with Ice Packs
Cat. No.
BT29694
Source
Escherichia Coli.
Appearance
White, lyophilized (freeze-dried) powder, sterile.
TNFRSF14 Human, Sf9
HVEM-Fc Human Recombinant, Sf9
Recombinant human TNFRSF14 protein, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain. It consists of 406 amino acids (39-202) with a molecular weight of 46.6kDa (Appears as approximately 40-57kDa on SDS-PAGE). The TNFRSF14 protein is fused to a 239 amino acid IgG His-Tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT27964
Source
Sf9, Baculovirus cells.
Appearance
The product is a clear, sterile filtered solution.
TNFRSF14 Mouse
HVEM Mouse Recombinant
TNFRSF14 Mouse, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain comprising 407 amino acids (39-206 aa). It has a molecular mass of 45.3 kDa. The protein is fused to a 239 amino acid hIgG-His-Tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28043
Source
Sf9, Baculovirus cells.
Appearance
Sterile Filtered colorless solution
TNFRSF17 Human
B-Cell Maturation Antigen Human Recombinant
Recombinant human TNFRSF17, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 50 amino acids with a molecular weight of 5.3 kDa. The protein is purified using standard chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28130
Source
Escherichia Coli.
Appearance
Sterile, white lyophilized (freeze-dried) powder.
TNFRSF17 Human, His
B-Cell Maturation Antigen Human Recombinant, His Tag
Recombinant human TNFRSF17 protein has been produced in E. coli. It is a single, non-glycosylated polypeptide chain consisting of 130 amino acids (residues 78-184). The protein has a molecular mass of 14.1 kDa. For purification purposes, a 23 amino acid His-tag is fused to the N-terminus of TNFRSF17. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT28168
Source
Escherichia Coli.
Appearance
A clear, colorless liquid that has been sterilized by filtration.
TNFSF7 Human, sf9
CD70 Human Recombinant, sf9
TNFSF7, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain containing 164 amino acids (39-193 a.a.) with a molecular mass of 18.2 kDa. It is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29270
Source
Sf9,
Baculovirus cells.
Appearance
Sterile filtered, colorless solution.
TNFSF8 Human
CD30 Ligand Human Recombinant
Recombinant human TNFSF8 is produced in E. coli. This non-glycosylated protein consists of a single polypeptide chain of 195 amino acids (residues 63-234), resulting in a molecular weight of 22 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and undergoes purification using specialized chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT29337
Source
Escherichia Coli.
Appearance
A clear, sterile-filtered solution.
TNFSF8 Human, Sf9
CD30 Ligand Human Recombinant, Sf9
Produced in Sf9 insect cells, TNFSF8 is a single, glycosylated polypeptide chain. It comprises 181 amino acids (residues 63-234), resulting in a molecular weight of 20.7 kDa. On SDS-PAGE, its apparent size ranges from 18 to 40 kDa. This TNFSF8 protein features a C-terminal 6-amino acid His tag and undergoes purification using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT29396
Source
Sf9,
Baculovirus cells.
Appearance
Clear, colorless solution that has been sterilized by filtration.
TRAIL Human
TRAIL / APO2 Ligand Human Recombinant
Recombinant Human TRAIL/APO 2 Ligand, expressed in E. coli, is a single-chain polypeptide. It lacks glycosylation and encompasses 168 amino acids (Met+Arg115-Gly281), resulting in a molecular weight of approximately 21 kDa. The purification of sTRAIL is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29488
Source
Escherichia Coli.
Appearance
The product appears as a sterile, white powder that has been lyophilized (freeze-dried).
Introduction
Definition and Classification
Tumor Necrosis Factor (TNF) is a cytokine, a type of signaling protein involved in systemic inflammation and is part of the body’s immune response. TNF is primarily produced by activated macrophages, although it can also be produced by other cell types such as lymphocytes, natural killer cells, and neurons. TNF is classified into two main forms:
- TNF-α (Tumor Necrosis Factor-alpha): The most studied form, involved in systemic inflammation and acute phase reactions.
- TNF-β (Tumor Necrosis Factor-beta): Also known as lymphotoxin, it is produced by lymphocytes and has similar but distinct functions compared to TNF-α.
Biological Properties
Key Biological Properties:
- Molecular Weight: TNF-α is a 17 kDa protein, while TNF-β is slightly larger.
- Structure: TNF-α is a trimeric protein, meaning it forms a complex of three identical subunits.
Expression Patterns:
- TNF-α: Expressed primarily by macrophages, but also by other immune cells such as T cells and natural killer cells.
- TNF-β: Expressed by activated lymphocytes.
Tissue Distribution:
- TNF is found in various tissues, including the spleen, liver, and adipose tissue. It is also present in the bloodstream during systemic inflammation.
Biological Functions
Primary Biological Functions:
- Inflammation: TNF is a key mediator of inflammation, promoting the recruitment of immune cells to sites of infection or injury.
- Cell Death: TNF can induce apoptosis (programmed cell death) in certain cells, which is crucial for controlling infections and preventing cancer.
- Immune Response: TNF plays a role in the activation and differentiation of immune cells, enhancing the body’s ability to fight off pathogens.
Role in Immune Responses:
- Pathogen Recognition: TNF helps in recognizing and responding to pathogens by activating immune cells and promoting the production of other cytokines.
Modes of Action
Mechanisms with Other Molecules and Cells:
- Receptors: TNF exerts its effects by binding to two receptors, TNFR1 and TNFR2, which are present on the surface of various cells.
- Binding Partners: TNF can interact with other cytokines and signaling molecules to amplify or modulate its effects.
Downstream Signaling Cascades:
- NF-κB Pathway: Activation of TNFR1 leads to the activation of the NF-κB pathway, which promotes the expression of genes involved in inflammation and cell survival.
- MAPK Pathway: TNF can also activate the MAPK pathway, leading to the production of inflammatory mediators.
Regulatory Mechanisms
Regulatory Mechanisms:
- Transcriptional Regulation: The expression of TNF is tightly regulated at the transcriptional level by various transcription factors, including NF-κB and AP-1.
- Post-Translational Modifications: TNF undergoes several post-translational modifications, such as glycosylation and cleavage, which can affect its activity and stability.
Applications
Biomedical Research:
- Disease Models: TNF is used in research to study inflammatory diseases, cancer, and autoimmune disorders.
Diagnostic Tools:
- Biomarkers: Elevated levels of TNF in the blood can serve as biomarkers for various inflammatory and autoimmune diseases.
Therapeutic Strategies:
- Anti-TNF Therapies: Drugs that inhibit TNF, such as infliximab and etanercept, are used to treat conditions like rheumatoid arthritis, Crohn’s disease, and psoriasis.
Role in the Life Cycle
Role Throughout the Life Cycle:
- Development: TNF is involved in embryonic development, particularly in the formation of the immune system.
- Aging: TNF levels can increase with age, contributing to age-related inflammation and diseases.
- Disease: Dysregulation of TNF is associated with various diseases, including chronic inflammatory conditions, cancer, and neurodegenerative disorders.
