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Product List
ALDOB Human
Aldolase B Fructose-Bisphosphate Human Recombinant
Recombinant human ALDOB, expressed in E. coli, is available as a single, non-glycosylated polypeptide chain. This protein comprises 388 amino acids, with a molecular weight of 42kDa. It includes amino acids 1-364 of the ALDOB sequence and is fused to a 24 amino acid His-tag at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT26257
Source
Escherichia Coli.
Appearance
Clear, colorless solution that has been sterilized by filtration.
ALDOC Human
Aldolase C Fructose-Bisphosphate Human Recombinant
Recombinant ALDOC protein, expressed in E. coli, is available as a single, non-glycosylated polypeptide chain. This protein consists of 364 amino acids (residues 1-364) and has a molecular weight of 39.4 kDa. The purification process involves proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT26335
Source
Escherichia Coli.
Appearance
Clear, colorless solution, sterile-filtered.
ALDOA Human
Aldolase-A Human Recombinant
This product consists of the human ALDOA enzyme recombinantly produced in E. coli. To facilitate purification and detection, a 20 amino acid His tag is fused to the N-terminal end. The protein is a single, non-glycosylated polypeptide chain comprising 384 amino acids (with the ALDOA sequence spanning residues 1-364) and possesses a molecular weight of 41.5 kDa. Purification is achieved using proprietary chromatographic methods, resulting in a highly pure ALDOA preparation.
Shipped with Ice Packs
Cat. No.
BT26178
Source
Escherichia Coli.
Appearance
The product is a clear, colorless solution that has been sterilized by filtration.
DERA Human
Deoxyribose-Phosphate Aldolase Human Recombinant
This product contains a lab-made version of the human DERA protein. It's a single chain of 338 amino acids, with a molecular weight of 37.3 kDa. The protein has been purified to a high degree. For easier handling, a His-tag is attached to the protein.
Shipped with Ice Packs
Cat. No.
BT26734
Source
E.coli.
Appearance
Clear, colorless liquid, sterilized by filtration.
TALDO1 Human
Transaldolase Human Recombinant
This product consists of the human recombinant TALDO1 protein, expressed in E. coli and purified to a high degree. The protein is a single, non-glycosylated polypeptide chain encompassing 357 amino acids (residues 1-337) with a molecular weight of 39.7 kDa. A 20 amino acid His Tag is fused to the N-terminus to facilitate purification. The protein has been purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT26828
Source
Escherichia Coli.
Appearance
The product is a clear, colorless solution that has been sterilized by filtration.
ALDOC Human, Active
Aldolase C Fructose-Bisphosphate Human Recombinant, Active
Recombinant human ALDOC, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 364 amino acids (1-364 a.a.) and exhibits a molecular weight of 39.4kDa. The purification process of ALDOC involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26420
Source
Escherichia Coli.
Appearance
A clear solution that has been sterilized through filtration.
ALDOC Human, His
Aldolase C Fructose-Bisphosphate Human Recombinant, His Tag
Recombinant human ALDOC, with a 20 amino acid His Tag fused at the N-terminal, is produced in E.Coli. This results in a single, non-glycosylated polypeptide chain consisting of 384 amino acids (1-364 a.a) and possessing a molecular weight of 41.6 kDa. Purification of ALDOC is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26488
Source
Escherichia Coli.
Appearance
The product is a clear, colorless solution that has been sterilized through filtration.
ALDOC Mouse
Aldolase C Fructose-Bisphosphate Mouse Recombinant
Recombinant ALDOC protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain containing 387 amino acids (residues 1-363) with a molecular weight of 41.9 kDa. This protein is fused to a 24 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26553
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile filtered solution.
DERA
Deoxyribose-Phosphate Aldolase E.Coli Recombinant
DERA, produced in E. coli, is a single, non-glycosylated polypeptide chain containing 279 amino acids (amino acids 1-259) and has a molecular mass of 29.9 kDa. It is fused to a 20 amino acid His-tag at the N-terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT26624
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
Introduction
Definition and Classification
Aldolase is an enzyme that plays a crucial role in glycolysis, the metabolic pathway that converts glucose into pyruvate, generating energy in the form of ATP. It catalyzes the reversible conversion of fructose-1,6-bisphosphate into glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP) . Aldolase is classified into three isozymes: Aldolase A (ALDOA), Aldolase B (ALDOB), and Aldolase C (ALDOC), which are distinguished by their electrophoretic and catalytic properties .
Biological Properties
Biological Functions
Modes of Action
Aldolase interacts with other molecules and cells through several mechanisms:
- Binding Partners: It binds to various molecules, including fructose-1,6-bisphosphate, to catalyze its conversion into G3P and DHAP .
- Downstream Signaling Cascades: Aldolase is involved in signaling pathways such as Wnt/β-catenin, EGFR/MAPK, Akt, and HIF-1α, which are crucial for cellular functions and responses .
Regulatory Mechanisms
The expression and activity of aldolase are tightly regulated through multiple mechanisms:
Applications
Aldolase has several applications in biomedical research and clinical settings:
- Biomedical Research: It is used as a biocatalyst in various biotechnological applications due to its high specificity and efficiency .
- Diagnostic Tools: Aldolase levels are measured in diagnostic tests to assess muscle and liver health .
- Therapeutic Strategies: Targeting aldolase has potential therapeutic applications, particularly in cancer treatment, where it can influence cancer cell metabolism and drug resistance .
Role in the Life Cycle
Aldolase plays a significant role throughout the life cycle, from development to aging and disease:
- Development: Aldolase is essential for energy production during development, supporting growth and differentiation .
- Aging: Changes in aldolase activity and expression are associated with aging and age-related diseases .
- Disease: Dysregulation of aldolase is linked to various diseases, including cancer, where it contributes to metabolic reprogramming and tumor progression .
