Product List

HRASLS3 Human

HRAS-Like Suppressor 3 Human Recombinant (PLA2G16)

HRASLS3 Human Recombinant amino produced in E.Coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-133) having a molecular mass of 14.9 kDa. The HRASLS3 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT21517
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.

PLA2G10 Human

Secreted Phospholipase A2-X Human Recombinant

Secreted Phospholipase A2-X Human Recombinant is manufactured with N-terminal fusion HisTag. PLA2G10 His-Tagged Fusion Protein, is 15.5 kDa containing 123 amino acid residues of the human secreted phospholipase A2-X and 16 additional amino acid residues - HisTag (underlined).

Shipped with Ice Packs
Cat. No.
BT21614
Source
Escherichia Coli.
Appearance
Sterile Filtered lyophilized (freeze-dried) powder.

PLA2G12 Human

Secreted Phospholipase A2-XII Human Recombinant

Secreted Phospholipase A2-XII Human Recombiannt was produced with N-terminal His-Tag. PLA2G12 His-Tagged Fusion Protein is 20.6 kDa containing 167 amino acid residues of the human secreted phospholipase A2-XII and 16 additional amino acid residues – His-Tag (underlined).

Shipped with Ice Packs
Cat. No.
BT21695
Source
Escherichia Coli.
Appearance
Filtered White lyophilized (freeze-dried) powder.

PLA2G1B Human

Secreted Phospholipase A2-IB Human Recombinant

Secreted Phospholipase A2-IB Human Recombinant is manufactured with N-terminal fusionf HisTag. PLA2G1B His-Tagged Fusion Protein is 16 kDa containing 126 amino acid residues of the human secreted phospholipase A2-IB and 16 additional amino acid residues - HisTag (underlined).

Shipped with Ice Packs
Cat. No.
BT21783
Source
Escherichia Coli.
Appearance
Lyophilized (freeze-dried) powder.

PLA2G2A Human

Secreted Phospholipase A2-IIA Human Recombinant

Secreted Phospholipase A2-IIA Human Recombinant is manufactured with N-terminal fusion of HisTag. PLA2G2A His-Tagged Fusion Protein is 15.8 kDa containing 124 amino acid residues of the human secreted phospholipase A2-IIA and 16 additional amino acid residues – HisTag.
Shipped with Ice Packs
Cat. No.
BT21848
Source
Escherichia Coli.
Appearance

Filtered lyophilized (freeze-dried) powder.

PLA2G2D Human

Secreted Phospholipase A2-IID Human Recombinant

Secreted Phospholipase A2-IID Human Recombinant was produced with N-terminal His-Tag. PLA2G2D His-Tagged Fusion protein is 16.4 kDa containing 125 amino acid residues of the human secreted phospholipase A2-IID and 16 additional amino acid residues – His-Tag (underlined).
Shipped with Ice Packs
Cat. No.
BT21947
Source
Escherichia Coli.
Appearance
Sterile Filtered lyophilized (freeze-dried) powder.

PLA2G2E Human

Secreted Phospholipase A2-IIE Human Recombinant

Secreted Phospholipase A2-IIE Human Recombinant manufactured with N-terminal His-Tag. PLA2G2E His-Tagged Fusion Protein is 15.8 kDa protein containing 123 amino acid residues of the human secreted phospholipase A2-IIE and 16 additional amino acid residues – His-Tag (underlined).

Shipped with Ice Packs
Cat. No.
BT22012
Source
Escherichia Coli.
Appearance
Sterile Filtered lyophilized (freeze-dried) powder.

PLA2G5 Human

Secreted Phospholipase A2-V Human Recombinant

Secreted Phospholipase A2-V Human Recombinant was produced with N-terminal His-Tag. PLA2G5 His-Tagged Fusion protein is 15.5 kDa containing 118 amino acid residues of the human secreted phospholipase A2-V and 16 additional amino acid residues – His-Tag (underlined).

Shipped with Ice Packs
Cat. No.
BT22124
Source
Escherichia Coli.
Appearance
Lyophilized (freeze-dried) powder.

PLA2G7 Human

Secreted Phospholipase A2-VII Human Recombinant

PLA2G7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 420 amino acids fragment (22-441) having a total molecular mass of 52.29kDa and fused with a 4.5kDa amino-terminal hexahistidine tag.
The PLA2G7 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22193
Source
Escherichia Coli.
Appearance
Sterile Filtered clear solution.

PLA2G7 Human, HEK

Secreted Phospholipase A2-VII Human Recombinant, HEK

Recombinant Human PLA2G7 produced in HEK293 cells is a polypeptide chain (22-441 a.a), fused to an 8 amino acid His-tag at C-terminus, containing a total of 428 amino acids.
PLA2G7 is purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT22266
Source
HEK293 cells.
Appearance
Sterile Filtered colorless solution.

Introduction

Definition and Classification

Secreted Phospholipase A2 (sPLA2) is a member of the phospholipase A2 superfamily, which comprises enzymes that hydrolyze the sn-2 acyl bond of glycerophospholipids to release fatty acids and lysophospholipids . sPLA2 enzymes are characterized by their low molecular weight, requirement for calcium ions (Ca²⁺) for activity, and a conserved His/Asp catalytic dyad . They are classified into several groups based on their structure and function, including groups IB, IIA, IIC, IID, IIE, IIF, III, V, X, XIIA, and XIIB .

Biological Properties

sPLA2 enzymes exhibit distinct biological properties, including specific expression patterns and tissue distribution. They are found in various mammalian tissues, such as the pancreas, kidney, and central nervous system . sPLA2 enzymes are also present in snake and insect venoms . Their expression can be induced during inflammation, and they play roles in metabolic regulation, including lipid metabolism and energy production .

Biological Functions

The primary biological functions of sPLA2 include the hydrolysis of phospholipids to produce fatty acids and lysophospholipids, which serve as precursors for bioactive lipid mediators such as prostaglandins and leukotrienes . sPLA2 enzymes are involved in immune responses, pathogen recognition, and host defense mechanisms . They contribute to inflammation, atherosclerosis, and other pathophysiological processes .

Modes of Action

sPLA2 enzymes interact with other molecules and cells through various mechanisms. They bind to specific receptors on cell surfaces, leading to the activation of downstream signaling cascades . The hydrolysis of phospholipids by sPLA2 results in the release of arachidonic acid, which is further metabolized into eicosanoids, potent mediators of inflammation . sPLA2 enzymes also modulate membrane composition and participate in lipid signaling .

Regulatory Mechanisms

The expression and activity of sPLA2 are tightly regulated by multiple mechanisms. Transcriptional regulation involves the activation of specific genes in response to inflammatory stimuli . Post-translational modifications, such as phosphorylation, can modulate the enzyme’s activity and localization . Calcium ions are essential for the catalytic activity of sPLA2, and their concentration can influence enzyme function .

Applications

sPLA2 enzymes have various applications in biomedical research, diagnostic tools, and therapeutic strategies. They are used as biomarkers for inflammatory diseases and cancer . Inhibitors of sPLA2 are being developed as potential therapeutic agents for conditions such as acute lung injury and atherosclerosis . sPLA2 enzymes are also studied for their roles in lipid metabolism and energy homeostasis .

Role in the Life Cycle

sPLA2 enzymes play crucial roles throughout the life cycle, from development to aging and disease. During development, they are involved in processes such as sperm maturation and capacitation . In adulthood, sPLA2 enzymes contribute to immune responses and metabolic regulation . In aging and disease, their dysregulation is associated with inflammatory conditions, metabolic disorders, and cancer .

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