Enzymes
Product List
PGAM2 Human, Active
Phosphoglycerate Mutase 2 Human Recombinant, Active
PGM1 Human
Phosphoglucomutase 1 Human Recombinant
PGM2 Human
Phosphoglucomutase 2 Human Recombinant
PMM1 Human
Phosphomannomutase 1 Human Recombinant
PMM2 Human
Phosphomannomutase 2 Human Recombinant
BPGM Human
2,3-Bisphosphoglycerate Mutase Human Recombinant
PGAM1 Human
Phosphoglycerate Mutase 1 Human Recombinant
PGAM1 Human, Active
Phosphoglycerate Mutase 1 Human Recombinant, Active
PGAM1 Mouse
Phosphoglycerate Mutase 1 Mouse Recombinant
PGAM1 Mouse, Active
Phosphoglycerate Mutase 1 Mouse Recombinant, Active
Introduction
Mutases are a subclass of isomerase enzymes that catalyze the transfer of functional groups within a molecule, resulting in the isomerization of the molecule. They play a crucial role in various metabolic pathways by facilitating the rearrangement of atoms within a substrate. Mutases are classified based on the type of functional group they transfer, such as phosphomutases, which transfer phosphate groups, and carbon mutases, which transfer carbon groups.
Key Biological Properties: Mutases exhibit high substrate specificity and catalytic efficiency. They often require cofactors such as metal ions or coenzymes to function effectively.
Expression Patterns: The expression of mutases varies across different tissues and developmental stages. Some mutases are ubiquitously expressed, while others are tissue-specific.
Tissue Distribution: Mutases are found in various tissues, including the liver, muscle, and brain. Their distribution is closely linked to the metabolic needs of the tissue.
Primary Biological Functions: Mutases play a pivotal role in metabolic pathways, including glycolysis, gluconeogenesis, and the citric acid cycle. They facilitate the conversion of substrates into intermediates that are essential for energy production and biosynthesis.
Role in Immune Responses: Some mutases are involved in the immune response by modulating the activity of immune cells and influencing the production of signaling molecules.
Pathogen Recognition: Certain mutases participate in the recognition and response to pathogens by altering the structure of molecules involved in pathogen detection.
Mechanisms with Other Molecules and Cells: Mutases interact with various molecules, including substrates, cofactors, and regulatory proteins. These interactions are essential for their catalytic activity and regulation.
Binding Partners: Mutases often form complexes with other enzymes or structural proteins, which can enhance their stability and activity.
Downstream Signaling Cascades: The activity of mutases can trigger downstream signaling pathways that regulate cellular processes such as metabolism, growth, and differentiation.
Regulatory Mechanisms: The expression and activity of mutases are tightly regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms.
Transcriptional Regulation: The transcription of mutase genes is controlled by various transcription factors and signaling pathways that respond to cellular and environmental cues.
Post-Translational Modifications: Mutases undergo post-translational modifications such as phosphorylation, acetylation, and ubiquitination, which can modulate their activity, stability, and interactions with other proteins.
Biomedical Research: Mutases are valuable tools in biomedical research for studying metabolic pathways and disease mechanisms. They are used in assays to measure enzyme activity and substrate concentrations.
Diagnostic Tools: Mutase activity can serve as a biomarker for certain diseases, and assays measuring their activity are used in clinical diagnostics.
Therapeutic Strategies: Mutases are potential targets for drug development, and modulating their activity can have therapeutic benefits in metabolic disorders, cancer, and infectious diseases.
Development: Mutases are essential for proper development, as they regulate metabolic pathways that provide energy and biosynthetic precursors for growing tissues.
Aging: The activity of mutases can decline with age, leading to metabolic imbalances and contributing to age-related diseases.
Disease: Mutase dysfunction is associated with various diseases, including metabolic disorders, cancer, and neurodegenerative conditions. Understanding their role in disease can inform the development of therapeutic interventions.
