Protein Kinase C Iota Human Recombinant
Recombinant human PRKCI, expressed in HEK cells, is a single, glycosylated polypeptide chain encompassing amino acids 1 to 596. With a 6-amino acid His-tag fused at the C-terminus, the protein has a total of 602 amino acids and a molecular weight of 69 kDa. The purification process involves proprietary chromatographic techniques.
HEK293 Cells.
Protein Kinase C (PKC) is a family of serine/threonine-specific protein kinases that play a crucial role in various cellular processes by phosphorylating target proteins. PKC enzymes are activated by signals such as increases in the concentration of diacylglycerol (DAG) or calcium ions (Ca²⁺) . The PKC family consists of fifteen isozymes in humans, divided into three subfamilies based on their second messenger requirements: conventional (cPKCs), novel (nPKCs), and atypical (aPKCs) .
PKC enzymes are involved in a wide range of biological functions, including cell growth, differentiation, apoptosis, and immune responses .
PKC enzymes exert their effects through various mechanisms, including interactions with other molecules and cells, binding partners, and downstream signaling cascades .
The expression and activity of PKC are tightly regulated through various mechanisms, including transcriptional regulation and post-translational modifications .
PKC has significant applications in biomedical research, diagnostic tools, and therapeutic strategies .
PKC plays a vital role throughout the life cycle, from development to aging and disease .