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Product List
CCNA2 Human
Cyclin-A2 Human Recombinant
This recombinant CCNA2 protein, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 456 amino acids (residues 1-432), resulting in a molecular weight of 51.1 kDa. The protein includes a 24-amino acid His-tag at the N-terminus to facilitate purification using proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT2050
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized through filtration.
CCNB1 Human
Cyclin-B1 Human Recombinant
Recombinant human CCNB1, produced in E. coli, is a single polypeptide chain with 457 amino acids (1-433) and a molecular weight of 50.9 kDa. This protein includes a 24 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2121
Source
E.coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
CCNB2 Human
Cyclin-B2 Human Recombinant
Recombinant human CCNB2, produced in E. coli, is a single polypeptide chain consisting of 422 amino acids (residues 1-398) with a molecular weight of 47.9 kDa. This protein features a 24 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2200
Source
E.coli.
Appearance
Clear, colorless solution that has been sterilized by filtration.
CCND2 Human
Cyclin D2 Human Recombinant
Recombinant human CCND2, expressed in E. coli, is available as a single, non-glycosylated polypeptide chain. This protein consists of 313 amino acids, encompassing residues 1 to 289 of the native CCND2 sequence, along with an N-terminal 24-amino acid His-tag for purification. The molecular weight of this recombinant CCND2 protein is 35.6 kDa. Purification is achieved through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2274
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
CCNG1 Human
Cyclin G1 Human Recombinant
Recombinant human CCNG1, expressed in E. coli, is a single, non-glycosylated polypeptide chain comprising 315 amino acids (specifically, amino acids 1 to 295). It has a molecular weight of 36.2 kDa. For purification purposes, a 20 amino acid His-tag is fused to the N-terminus of CCNG1, and purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT2368
Source
Escherichia Coli.
Appearance
The product is a clear, colorless solution that has been sterilized by filtration.
CCNH Human
Cyclin-H Human Recombinant
Recombinant human CCNH, produced in E. coli, is a single, non-glycosylated polypeptide chain of 343 amino acids (1-323 a.a.) with a molecular weight of 39.8 kDa. It includes a 20 amino acid His Tag and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT2457
Source
Escherichia Coli.
Appearance
Clear, colorless, and sterile filtered solution.
CCNI Human
Cyclin-I Human Recombinant
Recombinant human CCN1, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 400 amino acids (residues 1-377) with a molecular weight of 44.9 kDa. It includes an N-terminal 23 amino acid His-tag and is purified using proprietary chromatographic methods.
Shipped with Ice Packs
Cat. No.
BT2555
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Introduction
Definition and Classification
Cyclins are a family of proteins that play a crucial role in regulating the cell cycle by activating cyclin-dependent kinases (CDKs). They were first discovered by R. Timothy Hunt in 1982 while studying the cell cycle of sea urchins . Cyclins are classified based on their behavior and function during different phases of the cell cycle. The main classes include:
- G1 Cyclins: Present during the G1 phase, they help prepare the cell for DNA replication.
- G1/S Cyclins: These cyclins appear at the transition from G1 to S phase and initiate DNA replication.
- S Cyclins: Active during the S phase, they are involved in DNA synthesis.
- M Cyclins: Present during mitosis, they help in the formation of the mitotic spindle and chromosome alignment .
Biological Properties
Cyclins exhibit distinct biological properties, including:
- Expression Patterns: Cyclin levels oscillate throughout the cell cycle, with specific cyclins peaking at different phases .
- Tissue Distribution: Cyclins are ubiquitously expressed in proliferating cells across various tissues. However, their expression levels can vary depending on the tissue type and the cell’s proliferative state .
Biological Functions
Cyclins primarily function by binding to and activating CDKs, which then phosphorylate target proteins to drive cell cycle progression . They play a role in:
- Cell Cycle Regulation: Cyclins ensure the accurate transmission of genetic information by regulating the cell cycle checkpoints .
- Immune Responses and Pathogen Recognition: Cyclins are involved in the regulation of immune cell proliferation and differentiation, which is crucial for effective immune responses .
Modes of Action
Cyclins exert their effects through several mechanisms:
Regulatory Mechanisms
The expression and activity of cyclins are tightly regulated through:
- Transcriptional Regulation: Cyclin gene expression is controlled by various transcription factors and signaling pathways .
- Post-Translational Modifications: Cyclins undergo ubiquitination and subsequent degradation by the proteasome, ensuring their levels are appropriately regulated throughout the cell cycle .
Applications
Cyclins have several applications in biomedical research and clinical settings:
Role in the Life Cycle
