Histone Deacetylase 2 Human Recombinant
Histone Deacetylase 8 Human Recombinant
Sf9, Baculovirus cells.
Histone Deacetylase 8 Mouse Recombinant
Recombinant HDAC8 Mouse, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain. It comprises 383 amino acids (with amino acids 1-377 being specifically identified) and has a molecular weight of 42.5 kDa. Under reducing conditions on SDS-PAGE, it migrates between 40-57 kDa. This HDAC8 protein is expressed with a 6 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on histone and non-histone proteins . This action is crucial for the regulation of gene expression, as it allows histones to wrap DNA more tightly, thereby repressing gene transcription . HDACs are classified into four main classes based on their sequence homology to yeast enzymes and domain organization :
HDACs play a variety of roles in biological processes :
HDACs have significant applications in biomedical research and therapeutic strategies :
HDACs play crucial roles throughout the life cycle, from development to aging and disease :