Enzymes
Product List
CTSS Human
Cathepsin-S Human Recombinant
CTSS Mouse
Cathepsin-S Mouse Recombinant
CTSW Human
Cathepsin-W Human Recombinant
CTSZ Human
Cathepsin-Z Human Recombinant
CTSZ Human, Sf9
Cathepsin-Z Human Recombinant, Sf9
Sf9, Baculovirus cells.
CTSZ Mouse
Cathepsin-Z Mouse Recombinant
CTSZ Mouse, Active
Cathepsin-Z, Active Mouse Recombinant
Recombinant Mouse CTSZ, produced in Baculovirus, is a single, glycosylated polypeptide chain consisting of 292 amino acids (23-306 aa). It has a molecular weight of 32.8 kDa. The CTSZ protein is fused to an 8 amino acid His tag at the C-terminus and purified using proprietary chromatographic techniques.
Sf9, Baculovirus cells.
CTSC Mouse
Cathepsin-C Mouse Recombinant
Recombinant CTSC protein derived from mouse has been produced in HEK293 cells. This protein is a single polypeptide chain consisting of 444 amino acids (amino acids 25-462), resulting in a molecular weight of 50.5 kDa. A 6-amino acid Histidine tag is present at the C-terminus to facilitate purification, which is carried out using proprietary chromatographic techniques.
HEK293 cells.
CTSF Human, Sf9
Cathepsin-F Human Recombinant, Sf9
Produced in Sf9 Baculovirus cells, CTSF is a single, glycosylated polypeptide chain with a molecular weight of 52.5kDa. It comprises 474 amino acids (20-484.a.a). The protein is expressed with a 6 amino acid His tag at the C-Terminus and purified using proprietary chromatographic methods.
Sf9, Baculovirus cells.
Sterile filtered, colorless solution.
CTSL Human
Cathepsin-L Human Recombinant
Introduction
Cathepsins are a family of proteases (enzymes that degrade proteins) found in all animals and other organisms. The term “cathepsin” is derived from the Greek words “kata-” meaning “down” and “hepsein” meaning "boil" . These enzymes are primarily located in lysosomes, where they play a crucial role in protein degradation. Cathepsins are classified into three main types based on their catalytic mechanisms: cysteine proteases, aspartic proteases, and serine proteases .
Cathepsins are involved in several primary biological functions:
The expression and activity of cathepsins are tightly regulated through several mechanisms:
- Transcriptional Regulation: Gene expression of cathepsins is controlled by transcription factors.
- Post-Translational Modifications: Cathepsins undergo modifications such as glycosylation, which affect their stability and activity .
- Endogenous Inhibitors: Proteins like stefins, cystatins, and serpins regulate cathepsin activity by inhibiting their proteolytic functions .
Cathepsins have significant applications in biomedical research, diagnostics, and therapeutics:
- Biomedical Research: They are studied for their roles in various diseases, including cancer and cardiovascular diseases .
- Diagnostic Tools: Differential expression of cathepsins can serve as biomarkers for disease progression .
- Therapeutic Strategies: Selective inhibitors of cathepsins are being developed as potential treatments for diseases .
Cathepsins play vital roles throughout the life cycle, from development to aging and disease:
- Development: They are involved in tissue remodeling during embryogenesis and development .
- Aging: Cathepsin activity is linked to the degradation of cellular components, which is crucial for maintaining cellular homeostasis .
- Disease: Dysregulated cathepsin activity is associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
