PRDX2 Rat

Peroxiredoxin-2 Rat Recombinant

Recombinant PRDX2 from Rat, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 222 amino acids (with amino acids 1-198 present) and has a molecular weight of 24.3 kDa. This PRDX2 variant includes a 24 amino acid His-tag fused at the N-terminus. Purification is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25018
Source
Escherichia Coli.
Appearance
Clear, colorless solution, sterile filtered.

PRDX3 Human

Peroxiredoxin-3 Human Recombinant

Recombinant Human PRDX3, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 195 amino acids (residues 63-256). With a molecular weight of 21.5 kDa, it is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25095
Source
Escherichia Coli.
Appearance
Clear, colorless solution, sterile-filtered.

PRDX4 Human

Peroxiredoxin-4 Human Recombinant

Recombinant human PRDX4, expressed in E. coli, is a non-glycosylated polypeptide chain with a molecular weight of 28.8 kDa. It comprises 255 amino acids, spanning from positions 38 to 271. A 20-amino acid His-Tag is fused to the N-terminus of the PRDX4 protein, which undergoes purification using standard chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25171
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

PRDX5 Human

Peroxiredoxin-5 Human Recombinant

Recombinant human PRDX5, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 162 amino acids (spanning positions 53 to 214) and has a molecular weight of 17 kDa. The purification of PRDX5 is achieved using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25246
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterile filtered.

GLRX Mouse

Glutaredoxin Mouse Recombinant

This product consists of recombinant GLRX protein derived from mouse and produced in E. coli. It is engineered as a single, non-glycosylated polypeptide chain encompassing 130 amino acids, including the 107 amino acids of the GLRX protein (1-107 a.a) and a 23 amino acid His-tag fused at the N-terminus. The molecular weight of the recombinant protein is 14.3 kDa. Purification is achieved through proprietary chromatographic techniques to ensure high purity.
Shipped with Ice Packs
Cat. No.
BT24624
Source
Escherichia Coli.
Appearance
The product appears as a clear solution that has been sterilized by filtration.

PRDX2 Mouse

Eukaryotic Translation Initiation Factor 4E Mouse Recombinant

Recombinantly produced in E. coli, PRDX2 Mouse Recombinant is a non-glycosylated polypeptide chain with a single chain. It consists of 222 amino acids (1-198 a.a), with a molecular weight of 24.3 kDa. A 24 amino acid His-tag is fused to the N-terminus of PRDX2. Purification is achieved through proprietary chromatographic techniques.

Shipped with Ice Packs
Cat. No.
BT24726
Source
Escherichia Coli.
Appearance
A clear solution that has undergone sterile filtration.

PRDX1 Human

Peroxiredoxin-1 Human Recombinant

Recombinant Human Peroxiredoxin, fused with a 20 amino acid His tag at the N-terminus, is produced in E. coli. This single, non-glycosylated polypeptide chain (1-199) consists of 219 amino acids and has a molecular weight of 24 kDa. The purification process involves proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24803
Source
Escherichia Coli.
Appearance
Clear, colorless solution, sterile-filtered.

PRDX1 Mouse

Peroxiredoxin-1 Mouse Recombinant

Recombinant Mouse PRDX1, produced in Sf9 Baculovirus cells, is a single, glycosylated polypeptide chain with a molecular weight of 23.2kDa (appears at approximately 18-28kDa on SDS-PAGE). It comprises 207 amino acids (1-199a.a.). This PRDX1 protein is expressed with an 8 amino acid His tag at the C-terminus and purified through proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24879
Source
Sf9, Baculovirus cells.
Appearance
A clear, colorless solution that has been sterilized by filtration.

PRDX2 Human

Peroxiredoxin-2 Human Recombinant

Recombinant human PRDX2, expressed in E. coli, is a non-glycosylated polypeptide chain with a molecular weight of 21.8 kDa, consisting of 198 amino acids. The protein is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT24952
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.

PRDX6 Human

Peroxiredoxin-6 Human Recombinant

Recombinant human Peroxiredoxin-6, expressed in E. coli, is a non-glycosylated polypeptide chain containing 244 amino acids (including a 20 amino acid His tag at the N-terminus). This protein, with a molecular weight of 27.1 kDa, is purified using proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT25333
Source
Escherichia Coli.
Appearance
A clear, colorless solution that has been sterilized by filtration.
Definition and Classification

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that play a crucial role in reducing peroxides, such as hydrogen peroxide, alkyl hydroperoxides, and peroxynitrite . They are classified into six subgroups based on their structural and biochemical features: Prx1 (typical 2-Cys), Prx5, Prx6, PrxQ, Tpx, and AhpE . These enzymes are further categorized into 1-Cys and 2-Cys Prxs, depending on the number of cysteine residues involved in their catalytic mechanism .

Biological Properties

Peroxiredoxins are highly abundant in various tissues and are expressed in different cellular compartments . They are particularly abundant in erythrocytes, where they play a significant role in protecting red blood cells from oxidative stress . The expression patterns of Prxs vary across different tissues, with some isoforms being more prevalent in specific organs . For example, Prx2 is one of the most abundant proteins in erythrocytes after hemoglobin .

Biological Functions

The primary function of peroxiredoxins is to reduce peroxides, thereby protecting cells from oxidative damage . They also play a role in immune responses by modulating cytokine-induced peroxide levels . Additionally, Prxs are involved in pathogen recognition and defense mechanisms against infections . They act as molecular chaperones and participate in various signal transduction pathways .

Modes of Action

Peroxiredoxins interact with other molecules and cells through their highly reactive cysteine residues . They form disulfide bonds with their binding partners, which are then reduced by thioredoxin or other reducing agents . This interaction leads to the activation of downstream signaling cascades that regulate various cellular processes . Prxs also act as molecular chaperones, protecting proteins from aggregation under stress conditions .

Regulatory Mechanisms

The expression and activity of peroxiredoxins are regulated at multiple levels. Transcriptional regulation involves various transcription factors that respond to oxidative stress . Post-translational modifications, such as phosphorylation, acetylation, and nitration, also play a significant role in modulating Prx activity . These modifications can alter the enzyme’s structure, localization, and interaction with other proteins .

Applications

Peroxiredoxins have several applications in biomedical research, including their use as biomarkers for oxidative stress and inflammation . They are also being explored as potential therapeutic targets for diseases associated with oxidative damage, such as cancer and neurodegenerative disorders . Additionally, Prxs are used in diagnostic tools to detect oxidative stress levels in various diseases .

Role in the Life Cycle

Throughout the life cycle, peroxiredoxins play a vital role in maintaining cellular homeostasis . During development, they protect cells from oxidative damage and support proper cell differentiation and proliferation . In aging, Prxs help mitigate the effects of accumulated oxidative stress, thereby contributing to longevity . In disease states, such as cancer and neurodegenerative disorders, altered Prx expression and activity can impact disease progression and severity .

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