Acyl-CoA Thioesterase 11 Human Recombinant
Acyl-CoA Thioesterase 13 Human Recombinant
Acyl-CoA Thioesterase 7 Human Recombinant
Acyl-CoA Thioesterase 8 Human Recombinant
Carboxylesterase 1D Mouse Recombinant
Carboxylesterase 1G Mouse Recombinant
Esterase D,S-Formylglutathione Hydrolase Human Recombinant
Phosphodiesterase 6D cGMP-Specific Rod Delta Human Recombinant
Phosphodiesterase 6H cGMP-Specific Cone Gamma Human Recombinant
Protein Phosphatase Methylesterase 1 Human Recombinant
Esterases exhibit diverse biological properties, including broad substrate specificity and stability under various conditions. They are expressed in multiple tissues, including the liver, blood plasma, and various microbial environments . Their tissue distribution is extensive, with significant roles in lipid metabolism and detoxification processes .
Esterases play crucial roles in various biological functions:
Esterases interact with other molecules and cells through specific binding partners and downstream signaling cascades. The catalytic mechanism typically involves a serine residue in the active site, which attacks the carbonyl carbon of the ester bond, facilitated by histidine and aspartic/glutamic acid residues . This leads to the formation of an acyl-enzyme intermediate, which is subsequently hydrolyzed to release the products .
The expression and activity of esterases are regulated through various mechanisms:
Esterases have numerous applications in biomedical research, diagnostics, and therapeutics:
Throughout the life cycle, esterases play vital roles from development to aging and disease: