Growth Factors CD Antigens Enzymes Viral Antigens Recombinant Proteins Natural Proteins Monoclonal Antibodies Cytokines Polyclonal Antibodies Neurotrophins Chemokines Hormones Custom Antibodies Modified Histone Antibodies Tag/Control Antibodies Antibody Pairs Secondary Antibodies Small Molecular Antibodies Recombinant Antibodies ChIP Antibodies

Enzymes

Dehydrogenase

Creatine Kinases

Isomerase

Phosphatase

TPA

TGFBR

Transaminase

Cyclin-Dependent Kinase

PPARG

PI3-kinase

Transferase

Cyclin

Phosphorylase

Cyclophilin

Jun N-terminal Kinase

Jun Proto-Oncogene

Polymerase

Kallikrein

Protease

Deaminase

Ligase

Proteasome

Lipase

Decarboxylase

Lipocalin

Lyase

LYVE1

MMP

Protein Kinase-A

Protein Kinase-C

Protein Kinase Akt1/PKB alpha

Protein Kinases

TIMP

Mitogen-Activated Protein Kinase

Mutase

Natural Enzymes

Nuclease

Discoidin Domain Receptor Tyrosine Kinase

DNA Polymerase

TGM2

Reductase

EGF Receptor

Nucleotidase

Tyrosine Kinase

Endonuclease

Nudix Type Motif

Enolase

Ubiquitin Conjugating Enzyme

Enterokinase

Epimerase

Esterase

Oxidase

FGF Receptors

Oxygenase

FK506 Binding Protein

Uromodulin

VEGF Receptors

Fructosamine 3 Kinase

Paraoxonase

Galactosidase

Peptidase

Secreted Phospholipase A2

Glucosidase

Gluteradoxin

Other Enzymes

Serine Threonine Kinase

Glycogen synthase kinase

Sulfatase

Glycosylase

Synthase

Glyoxalase

Granzyme

ACE2

Guanylate Kinase

Hexokinase

Peroxiredoxin

Activating Transcription Factor

Histone Deacetylase

Adenylate Kinase

Heparanase

Protein Tyrosine Phosphatase

Hydratase

Synthetase

AHCY

Aldolase

Hydrolase

Alkaline Phosphatase

Asparaginase

Aurora Kinase

Beta Lactamase

Calcium/Calmodulin-Dependent Protein Kinase

TIE1,TIE2

Calcium and Integrin Binding

Carbonic Anhydrase

Hydroxylase

Casein Kinase

Cathepsin

Chitinase

Product List

HSD17B1 Human

Hydroxysteroid (17-beta) Dehydrogenase 1 Human Recombinant

Recombinant human HSD17B1, expressed in E. coli, is a non-glycosylated polypeptide chain. This single-chain protein consists of 352 amino acids, including a 24 amino acid His-tag at the N-terminus (amino acids 1-328), resulting in a molecular weight of 37.5 kDa. The purification process involves proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT9904

Source

Escherichia Coli.

Appearance

Clear, colorless solution, sterile-filtered.

View Details

HSD17B10 Human

Hydroxysteroid (17-beta) Dehydrogenase 10 Human Recombinant

Recombinant HSD17B10, expressed in E. coli, is a non-glycosylated polypeptide chain consisting of 271 amino acids (residues 12-261). With a molecular weight of 28.1 kDa, this protein is produced with a 21-amino acid His-Tag fused at the N-terminus to facilitate purification via standard chromatography techniques.

Shipped with Ice Packs

Cat. No.

BT9996

Source

Escherichia Coli.

Appearance

The product is a sterile, colorless solution that has been filtered for purity.

View Details

HSD17B11 Human

Hydroxysteroid (17-beta) Dehydrogenase 11 Human Recombinant

Recombinant human HSD17B11, expressed in E. coli with an N-terminal 21 amino acid His tag, is a single, non-glycosylated polypeptide chain. It consists of 287 amino acids (20-285 a.a.), resulting in a molecular weight of 31.4 kDa. Purification of HSD17B11 is achieved using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT10098

Source

Escherichia Coli.

Appearance

Sterile filtered, colorless solution.

View Details

HSD17B14 Human

Hydroxysteroid (17-beta) Dehydrogenase 14 Human Recombinant

This product is a recombinant human HSD17B14 protein. It is produced in E. coli and includes a 36 amino acid His tag fused at the N-terminus. The protein is a single, non-glycosylated polypeptide chain with a molecular weight of 32.4 kDa. It consists of 306 amino acids, with residues 1-270 representing the HSD17B14 sequence. The purification process involves proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT10148

Source

Escherichia Coli.

Appearance

The product is a clear, colorless solution that has been sterilized by filtration.

View Details

HSD17B8 Human

Hydroxysteroid (17-beta) Dehydrogenase 8 Human Recombinant

Recombinant human HSD17B8, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 281 amino acids (amino acids 1-261), with a molecular weight of 29.1 kDa. The protein includes a 20 amino acid His-tag fused at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT10210

Source

Escherichia Coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

View Details

lldD E. coli

L-Lactate Dehydrogenase E.Coli Recombinant

Recombinant lldD from E. coli is produced as a single, non-glycosylated polypeptide chain. It consists of 420 amino acids (residues 1-396), resulting in a molecular weight of 45.3 kDa. The protein includes an N-terminal 24 amino acid His-tag and is purified using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT11429

Source

E.coli.

Appearance

Clear, colorless solution, sterile filtered.

View Details

MDH E. coli

Malate Dehydrogenase Recombinant

This recombinant MDH, produced in E. coli, is a single polypeptide chain consisting of 336 amino acids (with the first 312 amino acids forming the MDH sequence). It has a molecular weight of 34.9 kDa. For purification purposes, a 24 amino acid His-tag is attached to the N-terminus. The protein is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT11520

Source

E.coli.

Appearance

Clear, colorless solution that has been sterilized by filtration.

View Details

MDH1 Chicken

Malate Dehydrogenase Chicken Recombinant

This product consists of Malate Dehydrogenase (MDH1) derived from chicken heart. The encoding gene for MDH1 was cloned from a chicken heart cDNA library. After expression, the enzyme is purified using advanced chromatographic methods to ensure high purity.

Shipped with Ice Packs

Cat. No.

BT11590

Source

Escherichia Coli.

Appearance

Provided as a sterile powder that has been freeze-dried.

View Details

MDH1 Human

Malate Dehydrogenase 1 Human Recombinant

Recombinant human MDH1, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 342 amino acids, with amino acids 1-334 representing the MDH1 sequence. The protein has a molecular weight of 37.4 kDa and includes an 8 amino acid His tag fused to the C-terminus. Purification is achieved using conventional chromatography techniques.

Shipped with Ice Packs

Cat. No.

BT11643

Source

Escherichia Coli.

Appearance

Clear, colorless solution, sterile-filtered.

View Details

NDUFAF4 Human

NADH Dehydrogenase 1 Alpha Subcomplex, Assembly Factor 4 Human Recombinant

Recombinant human NDUFAF4, expressed in E. coli, is a non-glycosylated polypeptide chain containing 198 amino acids (1-175) with a molecular weight of 22.7 kDa. It is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT12937

Source

Escherichia Coli.

Appearance

Clear, colorless and sterile filtered solution.

View Details

Showing 11 to 20 of 95 results

Introduction

Definition and Classification

Dehydrogenases are enzymes belonging to the oxidoreductase class, which catalyze the removal of hydrogen atoms from a substrate, transferring them to an electron acceptor such as NAD+, NADP+, FAD, or FMN . These enzymes play a crucial role in oxidation-reduction reactions within cells. Dehydrogenases are classified based on the type of substrate they act upon, such as alcohol dehydrogenase, lactate dehydrogenase, and glyceraldehyde-3-phosphate dehydrogenase .

Biological Properties

Dehydrogenases exhibit key biological properties, including their ability to regulate cellular redox balance by maintaining the ratio of NADH to NAD+. They are expressed in various tissues and have distinct expression patterns. For instance, lactate dehydrogenase is found in the heart, liver, and muscles, while alcohol dehydrogenase is primarily located in the liver. These enzymes are crucial for cellular respiration and energy production.

Biological Functions

The primary biological function of dehydrogenases is to facilitate oxidation-reduction reactions, which are essential for cellular metabolism. They play a significant role in energy production by participating in pathways such as glycolysis, the citric acid cycle, and the electron transport chain. Dehydrogenases also contribute to immune responses and pathogen recognition by modulating the redox state of cells, which can influence signaling pathways involved in immune activation.

Modes of Action

Dehydrogenases operate by transferring hydrogen atoms from a substrate to an electron acceptor. This process involves binding to specific substrates and electron acceptors, forming enzyme-substrate complexes. For example, alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde with the help of NAD+. The downstream signaling cascades triggered by dehydrogenase activity can lead to various cellular responses, including changes in gene expression and metabolic adjustments.

Regulatory Mechanisms

The expression and activity of dehydrogenases are tightly regulated through multiple mechanisms. Transcriptional regulation involves the control of gene expression by transcription factors that respond to cellular signals. Post-translational modifications, such as phosphorylation and acetylation, can alter the activity and stability of dehydrogenases. Additionally, allosteric regulation and feedback inhibition by metabolic intermediates play a role in modulating enzyme activity.

Applications

Dehydrogenases have numerous applications in biomedical research, diagnostics, and therapeutics. They are used as biomarkers for various diseases, such as lactate dehydrogenase in myocardial infarction. In research, dehydrogenases are employed to study metabolic pathways and enzyme kinetics. Therapeutically, they are targeted in drug development for conditions like cancer and metabolic disorders.

Role in the Life Cycle

Throughout the life cycle, dehydrogenases are involved in critical processes from development to aging and disease. During development, they support rapid cell growth and differentiation by providing energy and metabolic intermediates. In aging, changes in dehydrogenase activity can affect cellular metabolism and contribute to age-related diseases. In diseases such as Alzheimer’s and Parkinson’s, altered dehydrogenase function is linked to pathogenesis and progression.