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Enzymes

Transaminase

Creatine Kinases

Isomerase

Phosphatase

TPA

TGFBR

Cyclin-Dependent Kinase

PPARG

PI3-kinase

Transferase

Cyclin

Phosphorylase

Cyclophilin

Jun N-terminal Kinase

Jun Proto-Oncogene

Polymerase

Kallikrein

Protease

Deaminase

Ligase

Proteasome

Lipase

Decarboxylase

Lipocalin

Dehydrogenase

Lyase

LYVE1

MMP

Protein Kinase-A

Protein Kinase-C

Protein Kinase Akt1/PKB alpha

Protein Kinases

TIMP

Mitogen-Activated Protein Kinase

Mutase

Natural Enzymes

Nuclease

Discoidin Domain Receptor Tyrosine Kinase

DNA Polymerase

TGM2

Reductase

EGF Receptor

Nucleotidase

Tyrosine Kinase

Endonuclease

Nudix Type Motif

Enolase

Ubiquitin Conjugating Enzyme

Enterokinase

Epimerase

Esterase

Oxidase

FGF Receptors

Oxygenase

FK506 Binding Protein

Uromodulin

VEGF Receptors

Fructosamine 3 Kinase

Paraoxonase

Galactosidase

Peptidase

Secreted Phospholipase A2

Glucosidase

Gluteradoxin

Other Enzymes

Serine Threonine Kinase

Glycogen synthase kinase

Sulfatase

Glycosylase

Synthase

Glyoxalase

Granzyme

ACE2

Guanylate Kinase

Hexokinase

Peroxiredoxin

Activating Transcription Factor

Histone Deacetylase

Adenylate Kinase

Heparanase

Protein Tyrosine Phosphatase

Hydratase

Synthetase

AHCY

Aldolase

Hydrolase

Alkaline Phosphatase

Asparaginase

Aurora Kinase

Beta Lactamase

Calcium/Calmodulin-Dependent Protein Kinase

TIE1,TIE2

Calcium and Integrin Binding

Carbonic Anhydrase

Hydroxylase

Casein Kinase

Cathepsin

Chitinase

Product List

GPT Rat

Glutamic-Pyruvate Transaminase Rat Recombinant

Recombinant GPT from Rat, expressed in E. coli, is a single, non-glycosylated polypeptide chain. It consists of 519 amino acids, with the first 496 representing the GPT protein, and has a molecular weight of 57.5 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT1522

Source

E.coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

View Details

GPT2 Human

Glutamic-Pyruvate Transaminase 2 Human Recombinant

Recombinant human GPT2 is a 60.3 kDa protein containing 546 amino acids (specifically, amino acids 1-523). Produced in E. coli, this single polypeptide chain is fused to a 23 amino acid His-tag at its N-terminus and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1595

Source

E.coli.

Appearance

Clear, colorless, and sterile-filtered solution.

View Details

GPT2 Human, Active

Glutamic-Pyruvate Transaminase 2 Human Recombinant, Active

Recombinant human GPT2, produced in E. coli, is a single polypeptide chain with a molecular weight of 60.3 kDa. It consists of 546 amino acids, including a 23 amino acid His-tag at the N-terminus (amino acids 1-523). The protein is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1679

Source

E.coli.

Appearance

A clear, colorless solution that has been sterilized by filtration.

View Details

GPT2 Mouse

Glutamic-Pyruvate Transaminase 2 Mouse Recombinant

This product consists of recombinant Mouse GPT2, a single polypeptide chain with a molecular weight of 60.1 kDa. It is produced in E. coli and encompasses amino acids 1-522 of the native GPT2 sequence. For purification and detection purposes, a 21 amino acid His-tag is fused to the N-terminus. The recombinant protein has been purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1735

Source

E.coli.

Appearance

Clear, colorless solution, sterile-filtered.

View Details

GPT2 Mouse, Active

Glutamic-Pyruvate Transaminase 2, Active Mouse Recombinant

Recombinant GPT2 Mouse is produced in E. coli. It is a single, non-glycosylated polypeptide chain consisting of 542 amino acids (1-522 aa) and has a molecular weight of 60.1 kDa. The protein contains a 20 amino acid His tag at the N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1822

Source

Escherichia Coli.

Appearance

Sterile Filtered colorless solution.

View Details

GOT1 Mouse

Glutamic-Oxaloacetic Transaminase 1 Mouse Recombinant

Recombinant GOT1 Mouse, produced in E.Coli, is a single, non-glycosylated polypeptide chain consisting of 436 amino acids (1-413a.a) with a molecular weight of 48.6kDa. This GOT1 protein is fused to a 23 amino acid His-tag at the N-terminus and purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT768

Source

Escherichia Coli.

Appearance

Sterile filtered colorless solution.

View Details

GOT2 Human

Glutamic-Oxaloacetic Transaminase 2 Human Recombinant

Recombinant Human GOT2, expressed in E. coli, is a single, non-glycosylated polypeptide chain consisting of 424 amino acids (residues 30-430). It has a molecular weight of 47kDa. This GOT2 protein includes a 23 amino acid histidine tag fused at its N-terminus and is purified using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT857

Source

Escherichia Coli.

Appearance

Clear, colorless solution, sterile filtered.

View Details

GOT2 Human, Active

Glutamic-Oxaloacetic Transaminase 2 Human Recombinant, Active

This product consists of recombinant human GOT2, produced in E. coli. It is a single, non-glycosylated polypeptide chain encompassing amino acids 30 to 430, resulting in a molecular weight of 47 kDa. A 23 amino acid histidine tag is fused to the N-terminus to facilitate purification, which is achieved using proprietary chromatographic methods.

Shipped with Ice Packs

Cat. No.

BT950

Source

Escherichia Coli.

Appearance

The product is a sterile, colorless solution.

View Details

GOT2 Mouse

Glutamic-Oxaloacetic Transaminase 2 Mouse Recombinant

Recombinant Mouse GOT2, expressed in E. coli, is a monomeric, non-glycosylated polypeptide chain with a molecular weight of 46.8 kDa. The recombinant protein encompasses amino acids 30 to 430 of the GOT2 sequence, fused to a 21 amino acid His-tag at the N-terminus. Purification is achieved using proprietary chromatographic techniques.

Shipped with Ice Packs

Cat. No.

BT1076

Source

Escherichia Coli.

Appearance

Sterile filtered, colorless solution.

View Details

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Introduction

Definition and Classification

Transaminases, also known as aminotransferases, are enzymes that catalyze the transfer of an amino group from an amino acid to a keto acid. This process is known as transamination. Transaminases are crucial for the synthesis of amino acids, which are the building blocks of proteins. They are classified based on the specific amino/keto acid pairs they act upon. For example, alanine transaminase (ALT) and aspartate transaminase (AST) are two well-known types.

Biological Properties

Transaminases exhibit several key biological properties:

Expression Patterns: Transaminases are expressed in various tissues, with high concentrations in the liver, heart, and muscles.
Tissue Distribution: ALT is predominantly found in the liver, while AST is present in both the liver and heart.

Biological Functions

Transaminases play a vital role in:

Amino Acid Metabolism: They facilitate the conversion of amino acids to keto acids, which can enter metabolic pathways like the citric acid cycle.
Immune Responses and Pathogen Recognition: Transaminases are involved in the synthesis of amino acids necessary for the production of immune cells and antibodies.

Modes of Action

Transaminases operate through a mechanism involving the coenzyme pyridoxal phosphate (PLP). The process can be divided into two half-reactions:

The amino group from an amino acid is transferred to PLP, forming pyridoxamine phosphate.
Pyridoxamine phosphate then transfers the amino group to a keto acid, forming a new amino acid.

Regulatory Mechanisms

The expression and activity of transaminases are regulated through:

Transcriptional Regulation: Gene expression of transaminases is controlled by various transcription factors in response to cellular needs.
Post-Translational Modifications: Phosphorylation and other modifications can alter the activity of transaminases.

Applications

Transaminases have several applications in biomedical research and clinical practice:

Diagnostic Tools: Elevated levels of ALT and AST in the blood are used as biomarkers for liver and heart diseases.
Therapeutic Strategies: Transaminases are explored for their potential in developing treatments for metabolic disorders.

Role in the Life Cycle

Throughout the life cycle, transaminases are involved in:

Development: They are essential for the synthesis of amino acids required for growth and development.
Aging and Disease: Changes in transaminase activity are associated with aging and various diseases, including liver and cardiovascular conditions.