Recombinant Proteins
Product List
CST1 Human
Cystatin SN Human Recombinant
CST11 Human
Cystatin 11 Human Recombinant
CST3 Human, His Active
Cystatin C, His BioActive Human Recombinant
Recombinant human CST3, produced in E. coli, is a single, non-glycosylated polypeptide chain. It comprises 141 amino acids (residues 27-146), has a molecular weight of 15.6 kDa, and includes a 21 amino acid His tag at the N-terminus. Purification is achieved using proprietary chromatographic methods.
CST3 Mouse, sf9
Cystatin-C Mouse Recombinant, sf9
CST3 Protein, His
Cystatin-C Human Recombinant, His Tag
CST3 Rat
Cystatin C Rat Recombinant
CST4 Human, sf9
Cystatin 4 Human Recombinant, sf9
CSTB Human, Active
Cystatin-B, BioActive Human Recombinant
Recombinant Human CSTB, produced in E. coli, is a single, non-glycosylated polypeptide chain consisting of 118 amino acids (specifically, amino acids 1 to 98). It has a molecular weight of 13 kDa. The CSTB protein is fused to a 20 amino acid His tag at its N-terminus and is purified using proprietary chromatographic methods.
Cystatin-C Protein
Cystatin-C Human Recombinant
Escherichia Coli.
Introduction
Cystatins are a family of cysteine protease inhibitors that play a crucial role in regulating proteolytic activity within cells. They are classified into three main types:
- Type 1 Cystatins (Stefins): These are primarily intracellular proteins found in the cytosol of various cell types .
- Type 2 Cystatins: These are mainly extracellular secreted polypeptides, found in most body fluids .
- Type 3 Cystatins (Kininogens): These are multidomain proteins, with mammalian representatives including high-molecular-mass and low-molecular-mass kininogens .
Cystatins exhibit several key biological properties:
- Inhibitory Activity: They inhibit cysteine proteases such as cathepsins and legumain, which are involved in protein degradation .
- Expression Patterns: Cystatins are expressed in a wide variety of tissues and body fluids .
- Tissue Distribution: They are found in virtually all tissues, with specific types being more prevalent in certain tissues. For example, cystatin C is found in high concentrations in the brain and kidneys .
Cystatins serve several primary biological functions:
- Regulation of Protease Activity: They regulate the activity of cysteine proteases, preventing excessive proteolysis .
- Immune Response: Cystatins modulate immune responses by influencing the activity of cathepsins involved in antigen presentation and cytokine production .
- Pathogen Recognition: They play a role in recognizing and responding to pathogens by inhibiting proteases that pathogens use to invade host tissues .
Cystatins interact with other molecules and cells through several mechanisms:
The expression and activity of cystatins are controlled by various regulatory mechanisms:
Cystatins have several applications in biomedical research and clinical practice:
Cystatins play a role throughout the life cycle, from development to aging and disease:
- Development: They are involved in regulating protease activity during embryonic development and tissue remodeling .
- Aging: Changes in cystatin levels and activity have been associated with aging and age-related diseases .
- Disease: Dysregulation of cystatin activity is implicated in various diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer .
