Recombinant Proteins
Product List
C17ORF49 Human
Chromosome 17 Open Reading Frame 49 Human Recombinant
C19ORF80 Rat
Chromosome 19 Open Reading Frame 80 Rat Recombinant
C20ORF20 Human
Chromosome 20 Open Reading Frame 20 Human Recombinant
C10ORF54 Human
Chromosome 10 Open Reading Frame 54 Human Recombinant
C10ORF54 Mouse
Chromosome 10 Open Reading Frame 54 Mouse Recombinant
C11ORF31 Human
Chromosome 11 Open Reading Frame 31 Human Recombinant
SF20 Mouse
Chromosome 19 Open Reading Frame 10 Mouse Recombinant
VTA1 Human
Vps20-Associated 1 Homolog Human Recombinant
Introduction
An open reading frame (ORF) is a sequence of DNA that starts with a start codon (usually AUG) and ends with a stop codon (UAA, UAG, or UGA). It is a segment of DNA that can be transcribed into RNA and translated into a protein. ORFs are crucial for identifying potential protein-coding regions within a genome .
Key Biological Properties: ORFs are essential for gene prediction and annotation. They are used to identify potential protein-coding genes within a DNA sequence .
Expression Patterns: ORFs can be found in various regions of the genome, including coding and non-coding regions. They are transcribed into mRNA, which is then translated into proteins by ribosomes .
Tissue Distribution: The expression of ORFs can vary across different tissues and developmental stages. Some ORFs are ubiquitously expressed, while others are tissue-specific .
Primary Biological Functions: ORFs encode proteins that perform various functions within the cell, including enzymatic activities, structural roles, and regulatory functions .
Role in Immune Responses: Some ORFs encode proteins involved in immune responses, such as cytokines and receptors that recognize and respond to pathogens .
Pathogen Recognition: ORFs can encode proteins that recognize and bind to pathogen-associated molecular patterns (PAMPs), initiating immune responses .
Mechanisms with Other Molecules and Cells: ORFs encode proteins that interact with other molecules and cells through various mechanisms, including binding to receptors, forming complexes, and participating in signaling pathways .
Binding Partners: Proteins encoded by ORFs can have specific binding partners, such as other proteins, nucleic acids, or small molecules, which are crucial for their function .
Downstream Signaling Cascades: ORF-encoded proteins can activate downstream signaling cascades, leading to various cellular responses, such as gene expression, cell proliferation, and apoptosis .
Transcriptional Regulation: The expression of ORFs is regulated at the transcriptional level by various factors, including transcription factors, enhancers, and silencers .
Post-Translational Modifications: ORF-encoded proteins can undergo post-translational modifications, such as phosphorylation, ubiquitination, and glycosylation, which can affect their stability, localization, and activity .
Biomedical Research: ORFs are used in biomedical research to study gene function, protein interactions, and disease mechanisms .
Diagnostic Tools: ORFs can be used as biomarkers for diagnosing diseases, such as cancer and genetic disorders .
Therapeutic Strategies: ORFs are targeted in therapeutic strategies, such as gene therapy and the development of small molecule inhibitors .
Development: ORFs play a crucial role in development by encoding proteins that regulate cell differentiation, growth, and morphogenesis .
Aging: The expression and function of ORFs can change with aging, affecting cellular processes and contributing to age-related diseases .
Disease: Mutations or dysregulation of ORFs can lead to various diseases, including cancer, neurodegenerative disorders, and metabolic diseases .
