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Recombinant Human Intermediate conductance calcium-activated potassium channel protein 4 (KCNN4)
This recombinant HumanKCNN4 protein is a full-length protein produced through in vitro E.coli (cell-free) expression. Its purity is determined to be 85%+ by SDS-PAGE. Cell-free protein expression refers to the in vitro synthesis of a protein using translation-compatible extracts of whole cells. Essentially, these whole-cell extracts contain all the necessary macromolecules and components for transcription, translation, and even post-translational modification. These components include RNA polymerase, regulatory protein factors, transcription factors, ribosomes, and tRNA. When supplemented with cofactors, nucleotides, and the specific gene template, these extracts can synthesize proteins of interest within a few hours.
The KCNN4 gene encodes the KCa3.1/SK4 protein, which plays a crucial role in calcium-activated anion secretion in mice and humans. It is prominently expressed in non-excitable cells such as erythrocytes, lymphocytes, and placenta cells. The KCa3.1 protein has been observed to participate in the pacemaker activity of cardiomyocytes derived from human embryonic stem cells (hESC-CMs). It is implicated in cancer progression, including cell proliferation, apoptosis, epithelial-mesenchymal transition (EMT), and metastasis.Shipped with Ice Packs
Shipped with Ice Packs
Shipped with Ice Packs
Shipped with Ice Packs
Shipped with Ice Packs
Shipped with Ice Packs
Shipped with Ice Packs
