This recombinant Human WNT2B protein encompasses amino acids 1-391. The calculated molecular weight of the WNT2B protein is 59.8 kDa. Expression of this WNT2B protein is conducted in an in vitro e.coli expression system. An N-terminal 6xHis-SUMO tag has been fused into the coding gene segment of WNT2B, facilitating the detection and purification of the WNT2B recombinant protein during subsequent expression and purification stages.
The protein Wnt-2b (WNT2B) is a subject of extensive research, with primary areas of investigation spanning developmental biology, cell signaling, and tumorigenesis. In developmental biology, WNT2B, as a member of the Wnt family, plays a pivotal role in embryonic development and organ formation, particularly in the development of the nervous system and muscle tissues. In cell signaling, WNT2B regulates various cellular functions, including proliferation, differentiation, and migration, through the Wnt signaling pathway. In the context of tumor development, the aberrant expression of WNT2B is associated with the occurrence and progression of multiple cancers, making it a significant target in cancer biology research.