Recombinant Proteins
Product List
Recombinant Human Glucagon-like peptide 1 receptor (GLP1R)
Recombinant human Glucagon-like peptide 1 receptor (GLP1R), encompassing amino acids 24-463 with a 10xHis-tag at the N-terminus, was expressed in an in vitro E.coli expression system. The resulting protein represents the recombinant full-length of mature human GLP1R protein. This protein exhibits a purity exceeding 85%, as determined by SDS-PAGE analysis. Its calculated molecular weight is 53.6 kDa. This recombinant protein finds applications in the production of anti-GLP1R antibodies and in neuroscience research.
GLP1R is a G protein-coupled receptor for GLP1, exhibiting widespread expression in the central nervous system (CNS) and peripheral tissues, including the heart, kidney, and adipose tissue (AT). The binding of GLP1 to GLP1R triggers various biological roles, such as promoting glucose-dependent insulin secretion, inhibiting gastric emptying, and regulating food intake. Recent studies have highlighted the involvement of GLP1R in energy metabolism through direct stimulation of mitochondrial bioenergetics and the remodeling of brown adipose tissue.
