Recombinant Proteins
Product List
Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3)
This recombinant Mouse Bnip3 protein is a full-length protein expressed in vitro using an E. coli cell-free system. Purity is ≥85%, as determined by SDS-PAGE. Cell-free protein expression leverages whole-cell extracts containing all necessary components for transcription, translation, and post-translational modification (including RNA polymerase, regulatory and transcription factors, ribosomes, and tRNA). Supplementation with cofactors, nucleotides, and the target gene template enables efficient protein synthesis within hours.
Bnip3, a pro-apoptotic BH3-only protein of the Bcl-2 family, is implicated in apoptosis, programmed necrosis, autophagy, and mitophagy in cells and tissues subjected to hypoxia or ischemia. Beyond its role in cell death and metastasis, Bnip3 modulates various metabolic pathways, including lipid metabolism, glycolysis, and mitochondrial bioenergetics. Furthermore, Bnip3 plays a significant role in carcinogenesis; its upregulated expression is observed in lung, prostate, cervical, and breast cancers, correlating with aggressive tumor phenotypes and poor prognoses.
